Distinct Metabolic States Direct Retinal Pigment Epithelium Cell Fate Decisions
J. Raúl Perez-Estrada,
Jared A. Tangeman,
Maeve Proto-Newton
et al.
Abstract:During tissue regeneration, proliferation, dedifferentiation, and reprogramming are necessary to restore lost structures. However, it is not fully understood how metabolism intersects with these processes. Chicken embryos can regenerate their retina through retinal pigment epithelium (RPE) reprogramming when treated with fibroblast factor 2 (FGF2). Using transcriptome profiling, we uncovered extensive regulation of gene sets pertaining to proliferation, neurogenesis, and glycolysis throughout RPE-to-neural ret… Show more
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