Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps

Fliss-Isakov, Naomi; Zelber‐Sagi, Shira; Webb, Muriel; Halpern, Zamir; Shibolet, Oren; Kariv, Revital

doi:10.1002/oby.22001

Cited by 31 publications

(32 citation statements)

References 38 publications

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“…A cohort study involving 2244 patients indicated that visceral adipose tissue was dose-dependently associated with colorectal adenoma [23]. Similarly, abdominal obesity, hypertension, and a high HbA1c% increase the risk for polyps [24]. Consistent with previous reports, we found that uric acid and MS index were also strongly associated with colon polyp.…”

Section: Discussionsupporting

confidence: 90%

Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

Huang

Qiao

et al. 2019

Gastroenterology Research and Practice

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Background. This study investigated the relationships among the characteristics of colon polyps and potential risk factors, including metabolic condition, CEA level, uric acid level, and Helicobacter pylori (Hp) infection status. Method. Clinical data from patients who received colonoscopy were collected and analyzed, including patients’ gender, age, polyp pathology, metabolic syndrome (MS) status, CEA level, uric acid level, and Hp infection status. Patients were divided into a polyp group and a control group based on whether they presented with colon polyps. Then, clinical data were compared between the two groups to identify any differences between the groups and their relationships to colon polyps. Result. Compared with the control group, the polyp group had significant differences in patient gender, body mass index (BMI), waistline, blood pressure, fasting blood glucose level, blood lipid level, and uric acid level (p<0.05), but there were no significant differences in LDL and CEA levels (p>0.05). Patients with MS or a uric acid level>340 mg/dl had a greater tendency to develop colon polyps but this was not statistically significant. Conclusion. The incidence of colon polyps may be associated with MS and uric acid levels, but further studies are warranted to confirm this conclusion.

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Section: Discussionsupporting

confidence: 90%

Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

Huang

Qiao

et al. 2019

Gastroenterology Research and Practice

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“…Monosodium urate crystals stimulate inflammatory response by activation of toll-like receptor 4, which strongly promotes leukocyte to produce proinflammatory factors, which play a critical role in regulating neoplasm formation and cancer progression [12]. In other studies, abdominal obesity and hypertension were correlated with adenoma type polyps, whereas the strongest predictor for serrated polyps was a high triglyceride (TG) to high-density lipoprotein cholesterol levels (TG/HDL) ratio [13]. In obese patients, adipose tissue releases free fatty acids, growth factors, adipokines, and other proinflammatory factors, known to play a key role in regulating malignant transformation and cancer progression [14].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

Macarie

Bățagă

Mocan

et al. 2020

JGLD

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Background and Aims: The importance of sessile serrated lesions (SSLs) in the pathogenesis of colorectal carcinoma has been recently established. These are supposed to cause the so-called “interval cancer”, having a rapidly progressive growth and being difficult to detect and to obtain an endoscopic complete resection. We aimed to establish the most important metabolic risk factors for sessile serrated lesions. Methods: We performed a retrospective case-control study, on a series of 2918 consecutive patients who underwent colonoscopy in Gastroenterology and Endoscopy Unit, County Clinical Emergency Hospital, Târgu-Mureș, Romania between 1 st of January 2015-31 th of December 2017. In order to evaluate the metabolic risk factors for polyps’ development, enrolled participants were stratified in two groups, a study group, 33 patients with SSLs lesions, and a control group, 138 patients with adenomatous polyps, selected by systematic sampling for age and anatomical site. Independent variables investigated were: gender, smoking, alcohol consumption, obesity, arterial hypertension, diabetes, hypercholesterolemia, hypertriglyceridemia, hyperuricemia, nonalcoholic liver disease. Results: For SSLs the most common encountered localization was the right colon in 30.55% of cases. By comparative bivariate analysis between SSLs group and control group, it was observed that hypertension (p=0.03, OR 2.33, 95 %CI 1.03-5.24), obesity (p=0.03, OR 2.61, 95 %CI 1.08-6.30), hyperuricemia (p=0.04, OR 2.72, 95 %CI 1.28-7.55), high cholesterol (p=0.002, OR 3.42; 95 %CI 1.48-7.87), and high triglycerides level (p=0.0006, OR 5.75; 95 %CI 1.92-17.2) were statistically associated with SSLs development. By multivariate analysis hypertension and hypertriglyceridemia retained statistical significance. Conclusions: Our study showed that the highest prevalence of SSLs was in the right colon and hypertension and increased triglycerides levels were associated with the risk of SSLs development. These risk factors are easy to detect in clinical practice and may help identifying groups with high risk for colorectal cancer, where screening is recommended.

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“…Elevated HbA1c levels, abdominal obesity and hypertension correlate with the risk to develop gastrointestinal polyps. In addition, improper lipid metabolism with a high triglyceride to HDL ratio has been found to increase the risk to develop serrated adenomas [271].…”

Section: Lipidsmentioning

confidence: 99%

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance

2020

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Background Tumor initiation and subsequent progression are usually long-term processes, spread over time and conditioned by diverse aspects. Many cancers develop on the basis of chronic inflammation; however, despite dozens of years of research, little is known about the factors triggering neoplastic transformation under these conditions. Molecular characterization of both pathogenetic states, i.e., similarities and differences between chronic inflammation and cancer, is also poorly defined. The secretory activity of tumor cells may change the immunophenotype of immune cells and modify the extracellular microenvironment, which allows the bypass of host defense mechanisms and seems to have diagnostic and prognostic value. The phenomenon of immunosuppression is also present during chronic inflammation, and the development of cancer, due to its duration, predisposes patients to the promotion of chronic inflammation. The aim of our work was to discuss the above issues based on the latest scientific insights. A theoretical mechanism of cancer immunosuppression is also proposed. Conclusions Development of solid tumors may occur both during acute and chronic phases of inflammation. Differences in the regulation of immune responses between precancerous states and the cancers resulting from them emphasize the importance of immunosuppressive factors in oncogenesis. Cancer cells may, through their secretory activity and extracellular transport mechanisms, enhance deterioration of the immune system which, in turn, may have prognostic implications.

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Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps

Cited by 31 publications

References 38 publications

Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

Correlation between Colon Polyps and Metabolic Syndrome and HP Infection Status

Correlation of Metabolic Risk Factors with Sessile Serrated Lesions

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance

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