Distinct intrinsic network connectivity patterns of post‐traumatic stress disorder symptom clusters

Abstract

Our results are consistent with prior research showing intrinsic network disruptions in PTSD and imply heterogeneous connectivity patterns underlying PTSD symptom dimensions. These findings suggest possible biomarkers for PTSD and its dissociative subtype.

Typhoon-Related Post-Traumatic Stress Disorder and Trauma Might Lead to Functional Integration Abnormalities in Intra- and Inter-Resting State Networks: a Resting-State Fmri Independent Component Analysis

“…Furthermore, through template matching procedures, the component matched with DMN, ECN and SN (with the highest spatial correlation) best is selected. In the literature, ECN was often divided into the left and right components by ICA, and DMN was often divided into the dorsal, ventral and posterior (abbreviated as dDMN, vDMN and pDMN) [11]. Thus six templates including three DMN templates, two ECN templates and one SN template were used to select the corresponding network component in our study.…”

“…However, increased evidence indicates that local brain function abnormalities cannot comprehensively explain the complicated manifestation of PTSD. By contrast, exploring functional integration between regions may provide an opportunity to better elucidate the neural mechanism of PTSD [10,11].…”

Using Functional Neuroimaging to Refine the Diagnostic Construct of Borderline Personality Disorder

“…For example, recent works suggests that emotion dysregulation, a key aspect of BPD, may also be a useful transdiagnostic marker of pathology, amenable to inclusion within the RDoC matrix [190]. Evidence also suggests that the neural networks reviewed in the current project (e.g., the DMN, SN, and CEN) play an important role in other, related forms of psychopathology, including PTSD [191][192][193]. Moving the conversation on BPD toward more dimensional models (both psychiatric and neuroscientific) will facilitate the transfer of knowledge from the broader fields of psychology, psychiatry, and neuroscience and will bring this research to bear on, and better elucidate, BPD.…”

Relation between patterns of intrinsic network connectivity, cognitive functioning, and symptom presentation in trauma‐exposed patients with major depressive disorder

“…Interestingly, this finding suggests that higher levels of depersonalization (i.e., feeling as though one is disconnected from his/her body) are related to decreased connectivity of this core region associated with self‐referential processing. Similar findings have been reported in patients with PTSD (Tursich et al., 2015). Depersonalization is an important feature of depression, most often related to a history of comorbid trauma exposure and associated with greater illness severity (Molina‐Serrano et al., 2008; Žikić et al., 2009).…”

“…In addition, scores on the Dissociative Experiences Scale (indexing dissociative symptoms of PTSD including depersonalization and derealization) positively correlated with DMN connectivity with the dlPFC (a node of the CEN) in patients with PTSD related to early life trauma (Bluhm et al., 2009). Moreover, dissociative symptoms have been related to decreased integration of anterior and posterior DMN components (Tursich et al., 2015). Despite the increasing focus on dissociative symptoms in MDD and their relation to more severe symptoms and trauma exposure (Molina‐Serrano, Linotte, Amat, Souery, & Barreto, 2008; Žikić, Ćirić, & Mitković, 2009), it is unknown whether these symptoms are associated with altered network connectivity in patients with depression and a history of trauma.…”