Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development inChlamydia trachomatis
Shiomi Junker,
Vandana Singh,
Aamal G.M. Al-Saadi
et al.
Abstract:Partner Switching Mechanisms (PSM) are signal transduction systems comprised of a sensor phosphatase (RsbU), an anti-sigma factor (RsbW, kinase), an anti-anti-sigma factor (RsbV, the RsbW substrate), and a target sigma factor.Chlamydiaspp. are obligate intracellular bacterial pathogens of animals that undergo a developmental cycle transitioning between the infectious elementary body (EB) and replicative reticulate body (RB) within a host-cell derived vacuole (inclusion). Secondary differentiation events (RB to… Show more
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