Distinct immunologic features of finnish Sjögren's syndrome patients with HLA alleles DRB1*0301, DQA1*0501, and DQB1*0201. Alterations in circulating T cell receptor γ/δ subsets

Kerttula, T O; Collin, Pekka; Polvi, Anne; Korpela, Markku; Partanen, Jukka; Mäki, Markku

doi:10.1002/art.1780391017

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…Furthermore, this subgroup was associated with lower levels of circulating Vδ1-positive T cell receptor γ/ δ (TCR γ/δ) cells and higher levels of circulating CD45 Ropositive TCR γ/δ cells [26]. More recently, a Norwegian study revealed an association with HLA DQA1*0501 and DQB1*0201 with the presence of anti-Ro52 kD in patients with primary SS [20].…”

Section: Human Leukocyte Antigen Gene Associationsmentioning

confidence: 97%

The genetics of primary Sjögren’s syndrome

Sawalha¹,

Potts²,

Schmid³

et al. 2003

Curr Rheumatol Rep

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Primary Sjögren's syndrome is an autoimmune disease characterized clinically by dryness of the eyes and mouth. The use of different classification criteria for primary Sjögren's syndrome has led to dramatically different estimates of prevalence and incidence. Despite this, several genetic and environmental factors are thought to play a role in the susceptibility to primary Sjögren's syndrome, as is the current conceptual formulation of the pathogenesis of many other autoimmune maladies. Primary Sjögren's syndrome appears a complicated polygenic disorder with many genes interacting with environmental factors. Similar to many other polygenic autoimmune rheumatic diseases, human leukocyte antigen associations have been reported and confirmed. Additionally, other non-human leukocyte antigen candidate genes have been reported to reveal association with primary Sjögren's syndrome, but, in general, these effects are not confirmed. The authors review the human leukocyte antigen and non-human leukocyte antigen genetic associations herewith, knowing that new technologies are providing access to the entire genome for association studies. No doubt a much more comprehensive description of the genetics of this disorder will soon emerge.

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Section: Human Leukocyte Antigen Gene Associationsmentioning

confidence: 97%

The genetics of primary Sjögren’s syndrome

Sawalha¹,

Potts²,

Schmid³

et al. 2003

Curr Rheumatol Rep

View full text Add to dashboard Cite

show abstract

“…In a Finnish study the significant haplotypes were HLA-DRB1*0301-DQA1*0501-DQB1*0201[35]. Two Norwegian studies published in the same year (2001) showed HLA alleles as having association with SS patients with anti-SSA and/or anti-SSB, the alleles identified were DRB1*03-DQB1*02-DQA1*0501 [36] and DRB1*0301 and DRB3*0101 [37].…”

Section: Sjögren’s Syndrome Predisposition To Hlamentioning

confidence: 99%

Genetics of Sjögren's syndrome

Teos

Alevizos

2017

Clinical Immunology

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The pathogenesis of Sjögren’s syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases.

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“…In both diseases it has been reported that the expression level of HLA-DR in the epithelia is high 20,21 and that the proportion of CD4 ϩ Thelper cells in infiltrating cells is high, 22,23 suggesting the existence of a common immunological abnormality. Van De Merwe and colleagues proposed the following onset mechanism: autoantibodies blocking muscarinic receptors, which are involved in contraction of smooth muscles, are produced in patients with Sjögren's syndrome, thus resulting in interstitial cystitis.…”

Section: Discussionmentioning

confidence: 97%

A case of interstitial cystitis accompanying Sj�gren?s syndrome

et al. 2005

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A 51-year-old woman with interstitial cystitis was referred for screening of autoimmune disease. She was positive for results of Schirmer and Saxon tests and for ss/A and ss/B antibodies. Autoantibodies to type 3 muscarinic acetylcholine receptor were detected in the patient's serum by Western blotting. We diagnosed her as having interstitial cystitis accompanying Sjögren's syndrome. To enable early treatment, interstitial cystitis should be considered when patients with Sjögren's syndrome complain of urinary symptoms.

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Distinct immunologic features of finnish Sjögren's syndrome patients with HLA alleles DRB10301, DQA10501, and DQB1*0201. Alterations in circulating T cell receptor γ/δ subsets

Cited by 29 publications

References 28 publications

The genetics of primary Sjögren’s syndrome

The genetics of primary Sjögren’s syndrome

Genetics of Sjögren's syndrome

A case of interstitial cystitis accompanying Sj�gren?s syndrome

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