Abstract:Understanding immune mechanisms that mediate malaria protection is critical for improving vaccine development. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) induces high level of sterilizing immunity against malaria and serves as a valuable tool for the study of protective mechanisms. To identify vaccine-induced and protectionassociated responses during malaria infection, we performed transcriptome profiling of whole blood and in-depth cellular profiling of PBMCs from voluntee… Show more
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