Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34

Electronic volume, aldehyde dehydrogenase, and stem cell marker expression in cells from human peripheral blood apheresis samples

“…Our data confirms published studies showing that most ALDH1 bright /SSC low cells display phenotypic markers of primitive hematopoietic cells, that is, CD34, CD117, and CD133 (7,11,13). To our knowledge, no prior studies have evaluated the coexpression of ALDH1 bright cells with CD90 expression.…”

Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential

“…[8][9][10][11][12][13] In particular, CD34 þ ALDH bright (ALDH br ) cells from human umbilical cord blood (UCB) have been shown to contain all the NOD/SCID engrafting cells in the CD34 þ cells. 11 Furthermore, in mobilized peripheral blood stem cells (PBSC), the side-scatter low ALDH br (SSC lo ALDH br ) cells are highly enriched for human HSC. 13 Furthermore, ALDH correlated positively with the capability of PBSC graft in hematopoietic reconstitution during HSC transplantation (HSCT).…”

The hunt for cancer-initiating cells: a history stemming from leukemia

“…64 Flow cytometric analyses strategies that employ both surface marker expression and ALDH activity have been used both to enrich for HSCs and in discerning primitive and progenitor cell populations isolated from umbilical cord blood. 65 Recent evidence suggests that ALDH expression may also be a functional marker of a leukemia-initiating cell. 66 Utilizing a mouse model of NSCLC in which disease is initiated by activation of the K-ras oncogene, preliminary data from Tyler Jack's laboratory points to bronchioalveolar stem cells (BASCs) as candidates for chemo-resistant lung cancerinitiating cells (ISSCR Annual Meeting Abstracts, 2006).…”