Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study

Kim, Ki Wook; Allen, Digby W.; Briese, Thomas; Couper, Jennifer; Barry, Simon C.; Colman, Peter G; Cotterill, Andrew; Davis, Elizabeth A.; Giles, Lynne C.; Harrison, Leonard C.; Harris, Mark; Haynes, Aveni; Horton, Jessica L.; Isaacs, Sonia R; Jain, Komal; Lipkin, W. Ian; Morahan, Grant; Morbey, Claire; Pang, Chi Nam Ignatius; Papenfuss, Anthony T.; Penno, Megan A. S.; Sinnott, Richard; Soldatos, Georgia; Thomson, Rebecca L.; Vuillermin, Peter; Wentworth, John M.; Wilkins, Marc R.; Rawlinson, William D.; Craig, Maria E.

doi:10.1093/ofid/ofz025

Cited by 34 publications

(19 citation statements)

References 50 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our analysis of the longitudinal gut virome of 61 pregnant women (35 with type 1 diabetes and 26 without) in ENDIA, using VirCapSeq-VERT [22], 63% of samples tested positive for at least one virus and 29 genera of eukaryotic viruses were detected (Fig. 2).…”

Section: Virusesmentioning

confidence: 93%

Early-life factors contributing to type 1 diabetes

et al. 2019

View full text Add to dashboard Cite

The incidence of type 1 diabetes has increased since the mid-twentieth century at a rate that is too rapid to be attributed to genetic predisposition alone. While the disease can occur at any age, mounting evidence from longitudinal cohort studies of at-risk children indicate that type 1 diabetes associated autoantibodies can be present from the first year of life, and that those who develop type 1 diabetes at a young age have a more aggressive form of the disease. This corroborates the hypothesis that environmental exposures in early life contribute to type 1 diabetes risk, whether related to maternal influences on the fetus during pregnancy, neonatal factors or later effects during infancy and early childhood. Studies to date show a range of environmental triggers acting at different time points, suggesting a multifactorial model of genetic and environmental factors in the pathogenesis of type 1 diabetes, which integrally involves a dialogue between the immune system and pancreatic beta cells. For example, breastfeeding may have a weak protective effect on type 1 diabetes risk, while use of an extensively hydrolysed formula does not. Additionally, exposure to being overweight pre-conception, both in utero and postnatally, is associated with increased risk of type 1 diabetes. Epidemiological, clinical and pathological studies in humans support a role for viral infections, particularly enteroviruses, in type 1 diabetes, but definitive proof is lacking. The role of the early microbiome and its perturbations in islet autoimmunity and type 1 diabetes is the subject of investigation in ongoing cohort studies. Understanding the interactions between environmental exposures and the human genome and metagenome, particularly across ethnically diverse populations, will be critical for the development of future strategies for primary prevention of type 1 diabetes.

show abstract

Section: Virusesmentioning

confidence: 93%

Early-life factors contributing to type 1 diabetes

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In organ transplant recipients, PBVs were predictive of the occurrence of severe enteric graft-vs.-host disease (GVHD), and correlated with the high levels of GVHD severity markers in feces (41). Recently, it was demonstrated that pregnant women with type 1 diabetes (T1D) are more likely to harbor PBVs than those without T1D (42).…”

Section: Picobirnavirus Infection In Humans and Animalsmentioning

confidence: 99%

The True Host/s of Picobirnaviruses

Ghosh

Malik

2021

Front. Vet. Sci.

View full text Add to dashboard Cite

Picobirnaviruses (PBVs) are bisegmented double-stranded RNA viruses that have been detected in a wide variety of animal species including invertebrates and in environmental samples. Since PBVs are ubiquitous in feces/gut contents of humans and other animals with or without diarrhea, they were considered as opportunistic enteric pathogens of mammals and avian species. However, the virus remains to be propagated in animal cell cultures, or in gnotobiotic animals. Recently, the classically defined prokaryotic motif, the ribosomal binding site sequence, has been identified upstream of putative open reading frame/s in PBV and PBV-like sequences from humans, various animals, and environmental samples, suggesting that PBVs might be prokaryotic viruses. On the other hand, based on the detection of some novel PBV-like RNA-dependent RNA polymerase sequences that use the alternative mitochondrial genetic code (that of mold or invertebrates) for translation, and principal component analysis of codon usage bias for these sequences, it has been proposed that PBVs might be fungal viruses with a lifestyle reminiscent of mitoviruses. These contradicting observations warrant further studies to ascertain the true host/s of PBVs, which still remains controversial. In this minireview, we have focused on the various findings that have raised a debate on the true host/s of PBVs.

show abstract

“…The advent of metagenomics has greatly enhanced our ability to detect known and novel viral sequences in unbiased fashion and to establish novel associations of these sequences with various disease [1][2][3][4][5][6][7]. However, it is not known whether the virome plays a causative role or not.…”

Section: Lack Of Culture Systems To Propagate Components Of the Viromementioning

confidence: 99%

5 challenges in understanding the role of the virome in health and disease

Wang

2020

PLoS Pathog

View full text Add to dashboard Cite

Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study

Cited by 34 publications

References 50 publications

Early-life factors contributing to type 1 diabetes

Early-life factors contributing to type 1 diabetes

The True Host/s of Picobirnaviruses

5 challenges in understanding the role of the virome in health and disease

Contact Info

Product

Resources

About