Distinct gene expression profiles characterize the histopathological stages of disease in
            <i>Helicobacter-</i>
            induced mucosa-associated lymphoid tissue lymphoma

Mueller, Anne; O’Rourke, Jani; Grimm, Jan; Guillemin, Karen; Dixon, M. F.; Lee, Adrian V.; Falkow, Stanley

doi:10.1073/pnas.242741699

Cited by 96 publications

(92 citation statements)

References 38 publications

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“…Similarly, SPRR1A and SPRR2A are strongly induced in cardiomyocytes responding to biomechanical/ischemic stress, and these proteins could protect cardiomyocytes against ischemic injury [30]. The SPRR2A protein was also reported to be highly induced in gastric mucosa upon Helicobacter pylori infection in the human stomach [31]. And SPRR genes are activated during IL-13 mediated immune response in the lung [32].…”

Section: Discussionmentioning

confidence: 98%

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Tan

Sun

et al. 2006

Reprod. Nutr. Dev.

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-Small proline-rich proteins (SPRR) are known to construct the cornified cell envelope (CE) in the stratified squamous epithelial cell. Their functions in the simple epithelium such as the uterine epithelium are not clear hitherto. In the present study, the mRNA expression patterns of sprr2 family members in the mouse uterus and vagina during the estrous cycle and pregnancy as well as their regulation by steroids were investigated. Using semi-quantitative RT-PCR, it was revealed that the transcripts of sprr2b, 2e and 2g genes were up-regulated in the proestrous and estrous uteri, and sprr2d was up-regulated only in the estrous uterus. In the vagina, transcription of sprr2a, 2b, 2d, 2e and 2k genes were up-regulated at the metestrous stage. Northern blot analysis demonstrated that the overall expression of sprr2 was highly up-regulated in the estrous uterus and the metestrous vagina. During pregnancy, the sprr2 mRNA in the uterus was sharply repressed from day 3 postcoitus on, and began to be induced around labor time. In situ hybridization showed that the sprr2 transcripts were localized in uterine luminal and glandular epithelial cells as well as vaginal stratified epithelial cells. In ovariectomized mice, the expression of sprr2a, 2d, 2e and 2f genes in the uterus were induced by estrogen, and the effect of estrogen on sprr2d and 2e expression could be partly abolished by progesterone. The data indicate that the sprr2 genes have unique regulation patterns in different reproductive tissues under different physiological conditions, and the encoded proteins might play diverse functions in the female reproductive system. small proline-rich protein / uterus / estrous cycle / pregnancy / stress

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Section: Discussionmentioning

confidence: 98%

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Tan

Sun

et al. 2006

Reprod. Nutr. Dev.

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“…Probe labeling and DNA microarray experiments were performed as described at http://cmgm. stanford.edu/pbrown/protocols/index.html [17]. Hybridized chips were scanned using Affymetrix 428 TM array scanner and the images were analyzed using GenowizTM software (Ocimum Biosolutions, Hyderabad, India).…”

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confidence: 99%

Changes in the Cytokine and Toll-Like Receptor Gene Expression Following Infection of Indigenous and Commercial Chickens With Infectious bursal disease virus

et al. 2011

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A comparative study of cytokine and toll-like receptor (TLR) mRNA expression in 3 weeks old indigenous and commercial chickens infected with a very virulent strain of Infectious bursal disease virus (IBDV) was performed using a custom-made microarray chip. In uninfected indigenous chickens, the basal levels of interleukin (IL) 15 were lower and IL 16 was higher than their commercial counterparts. In the IBDV infected indigenous chickens, only IL16 gene expression was down regulated, while TLR3 expression was up regulated significantly. In the IBDV infected commercial chickens IL15, IL16 and TLR3 were down regulated. But, IL1-b, IL2, IL8, IL12, IL17, interferon (IFN)-a and b were significantly increased compared with the control. In IBDV infected indigenous chickens, IL15, IFN-c, beta-defensin and TLR3 were up regulated compared to virus-infected commercial chickens. The results suggested that up regulation of TLR3, a ligand for double-stranded (ds) RNA probably could account for the possible clinical resistance in these birds. There was a 5.2 fold difference by quantitative real-time RT-PCR between indigenous and commercial chickens in TLR3 mRNA expression. Therefore, TLR3, a receptor for dsRNA could be a putative molecule that could play a role in differential innate and adaptive immune responses to IBDV in commercial and indigenous chickens.

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“…Examples include greater than 100-fold increases seen in the intestine after small bowel resection 10 or after introduction of commensal bacteria into germ-free mice. 11,12 SPRR proteins are also expressed in ovarian epithelial cells, 13 in uterine lining epithelium at certain stages of the estrous cycle, 8,14 during development of the prostate gland, 15 and in regenerating peripheral neurons. 16 Except for neuronal regeneration, the physiologic significance of SPRR expression under these circumstances is assumed to be broadly related to barrier function because of their role in the skin.…”

mentioning

confidence: 99%

“…16 Except for neuronal regeneration, the physiologic significance of SPRR expression under these circumstances is assumed to be broadly related to barrier function because of their role in the skin. 12 However, mechanisms of SPRR involvement in barrier function unrelated to squamous differentiation or CE are not understood.…”

mentioning

confidence: 99%

Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation

Nozaki

Lunz

Specht

et al. 2005

Laboratory Investigation

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Small proline-rich proteins 2 (SPRR2) are coordinately expressed with other epidermal differential complex (EDC) genes in the skin. They function as crosslinking proteins that form bridges between other proteins that comprise the cornified cell envelope, which is the major barrier against the environment. IL-6 is invariably produced at sites of biliary tract injury and IL-6-deficient (IL-6 À/À ) mice show impaired barrier function after bile duct ligation (BDL). Screening microarray analysis identified noncoordinate expression of SPRR2 as a candidate gene that is: (a) expressed in biliary epithelial cells (BEC); (b) IL-6 responsive; and (c) potentially related to biliary barrier function. Therefore, we studied in detail the regulation of BEC SPRR2A expression, in vitro; and tested the hypothesis that if BEC SPRR2 expression contributes to biliary barrier function, it should be increased after BDL in IL-6-wild type (IL-6 þ / þ ) mice and not in IL-6 À/À mice. In vitro studies confirmed that IL-6/gp130-signaling, mediated primarily by signal transducer and activator of transcription 3 (STAT3), stimulated noncoordinate BEC SPRR2 expression. In vivo, noncoordinate upregulation of BEC SPRR2 expression after BDL was seen in the IL-6 þ / þ mice and was unrelated to squamous metaplasia. IL-6 À/À mice showed deficient BEC SPRR2 expression after BDL associated with impaired barrier function, as evidenced by smaller diameters of obstructed ducts, decreased bile volume, and an inability to form 'white bile' compared to IL-6 þ / þ mice at 12 weeks after BDL. IL-6 replacement therapy reversed the barrier defect in IL-6 À/À mice after BDL, coincident with recovery of SPRR2A expression. SPRR2 in diseased mouse and human liver localized subjacent to the apical plasma membrane of BEC lining bile ducts, but was more diffusely expressed throughout the cytoplasm of cholangioles. In conclusion, BEC IL-6/gp130/STAT3 signaling noncoordinately upregulates BEC SPRR2 that appears to contribute to modification of the biliary barrier under conditions of stress.

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Distinct gene expression profiles characterize the histopathological stages of disease in Helicobacter- induced mucosa-associated lymphoid tissue lymphoma

Cited by 96 publications

References 38 publications

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Gene expression pattern and hormonal regulation of Small Proline-Rich Protein 2 family members in the female mouse reproductive system during the estrous cycle and pregnancy

Changes in the Cytokine and Toll-Like Receptor Gene Expression Following Infection of Indigenous and Commercial Chickens With Infectious bursal disease virus

Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation

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