Distinct Expression Pattern of Cytokines in Semen of Men with Genital Infection and Oligo‐Terato‐Asthenozoospermia

Matalliotakis, Ioannis; Arıcı, Aydın; Goumenou, Anastasia G.; Koumantakis, Georgios; Selam, Belgin; Matalliotakis, G.; Koumantakis, E.

doi:10.1034/j.1600-0897.2002.01086.x

Cited by 29 publications

(47 citation statements)

References 22 publications

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“…Controversy exists as to whether elevated cytokine levels are related to semen quality. Previous studies suggested that elevated cytokine levels were not related to semen quality (Comhaire et al, 1994;Dousset et al, 1997;Matalliotakis et al, 1998;Eggert-Kruse et al, 2001;Matalliotakis et al, 2002), although more recent studies have supported such a relationship (Furuya et al, 2003;Kopa et al, 2005). The advantage of the present study is that it is the first to specifically investigate levels of both IL-6 and IL-8 in semen from C trachomatis-infected and -noninfected patients.…”

Section: Discussionmentioning

confidence: 87%

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Kokab

Akhondi

Sadeghi

et al. 2010

Journal of Andrology

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The aim of this study was to determine whether interleukin (IL)-6 and IL-8 concentrations, as well as numbers of seminal leukocytes in a population of infertile men, some of whom were Chlamydia trachomatis positive, were related to chlamydial infection. Our patient group included 255 men attending for diagnostic semen analysis as part of infertility investigations. Significantly raised levels of IL-8, but not IL-6, were found in C trachomatis-infected patients but not in uninfected patients. Raised IL-8 levels in semen were also associated with an increase in semen volume. There was a relationship between C trachomatis infection and lower progressive motile sperm, as well as an increase in seminal leukocytes. The overall prevalence rate for C trachomatis was 6.2%, and more infections were detected in semen than in first void urine. This study supports the suggestion that IL-8 might be used as a marker for male genital tract infection, especially when due to C trachomatis. In this study, there was a relationship between the presence of C trachomatis in semen and alterations of some semen parameters. Further investigations should be performed to understand the disparities of first void urine and semen testing for detection of C trachomatis in males.

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Section: Discussionmentioning

confidence: 87%

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Kokab

Akhondi

Sadeghi

et al. 2010

Journal of Andrology

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“…In man, there has been extensive interest in seminal plasma cytokine profile, which has been characterised for IL-1a/b, IL-2, IL-4, IL-6, IL-8, IL-10, IL-11, IL-12, tumour necrosis factor (TNF)-a/b, IFN-a/g, TGF-b1, RANTES, CSF-1, G-CSF, macrophage-CSF, stem cell factor, monocyte chemotactic and activating factor, macrophage migration inhibitory factor and vascular endothelial growth factor as well as an array of their soluble receptors (Naz & Stanley 1995, Shimoya et al 1995, Frenette et al 1998, Fujisawa et al 1998a,b, Matalliotakis et al 1998a,b, 2002, Omu et al 1998, Huleihel et al 1999, Naz & Leslie 2000, Maegawa et al 2002, Gutsche et al 2003, Paulis et al 2003, Basu et al 2004. However, these studies have been limited in the array of cytokines investigated in individual patients, and their focus has principally been on the association of these inflammatory mediators with a variety of disorders resulting in male factor infertility and/or characterised by inflammatory processes.…”

Section: Introductionmentioning

confidence: 99%

Multiplex determination of murine seminal fluid cytokine profiles

Gopichandran¹,

Ekbote²,

Walker³

et al. 2006

Reproduction

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“…Investigators previously demonstrated that 90K enhances generation of cytotoxic effector cells (Ulrich et al, 1994) as well as the secretion of IL-1, IL6, and tumor necrosis factor alpha (Powell et al, 1995). As those and other interleukins (IL-8 and IL-11) involved in the inflammatory reaction to tissue damage caused by infection (Comhaire et al, 1999) were previously observed to be increased in the ejaculate of patients with male accessory gland infection compared to controls (Alexander et al, 1998;Matalliotakis et al, 2002), a comparable increase of seminal 90K compared to controls could be expected in our patients. However, our finding of comparatively lower seminal 90K in patients is not surprising if we hypothesize that patients with male accessory gland infection harbor a disregulated local immune response.…”

Section: Discussionmentioning

confidence: 99%

Detection of 90K/MAC‐2BP in the Seminal Plasma of Infertile Males With Accessory Gland Infection and the Autoimmune Pathogenetic Hypothesis

Caroppo

Niederberger

Iacovazzi

et al. 2006

Journal of Andrology

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The purpose of the study was to evaluate 90K/MAC-2BP, a glycoprotein member of the Scavenger Receptor Cystein Rich superfamily, in the seminal plasma of infertile male patients with male accessory gland infection in order to investigate a putative autoimmune pathogenesis. 90K seminal concentration and sperm parameters were evaluated in 50 patients with male accessory gland infection at baseline and after cycles of treatment with Levofluoxacin 500 mg daily for 15 days plus serratiopeptidase 10 mg daily for 30 days. Treatment was continued for up to 6 cycles in cases of persistant bacteriospermia and/or clinical and ejaculatory signs of the disease. Patients with persistant male accessory gland infection after 6 cycles were defined as nonresponders. The same parameters were evaluated at baseline and after a 2-month period in 30 healthy controls. Patients with male accessory gland infection showed impaired sperm parameters and had lower seminal 90K concentration compared to controls. After treatment, seminal 90K level significantly increased in patients compared to controls. Twenty-two patients responded to treatment (44%), while 28 were nonresponders (56%). No difference in pretreatment and posttreatment sperm parameters and seminal 90K was observed between the 2 subgroups. Thirteen patients (26%) had identifiable bacteriospermia: significantly less pretreatment seminal 90K was observed compared to patients without bacteriospermia. Seminal 90K is decreased in patients with male accessory gland infection, and may be restored by a treatment with quinolones. However, the clinical utility of a 90K assay in these patients remains uncertain, as its level is not predictive of response to treatment.

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Distinct Expression Pattern of Cytokines in Semen of Men with Genital Infection and Oligo‐Terato‐Asthenozoospermia

Cited by 29 publications

References 22 publications

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Raised Inflammatory Markers in Semen From Men With Asymptomatic Chlamydial Infection

Multiplex determination of murine seminal fluid cytokine profiles

Detection of 90K/MAC‐2BP in the Seminal Plasma of Infertile Males With Accessory Gland Infection and the Autoimmune Pathogenetic Hypothesis

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