Distinct Effects of Body Mass Index and Waist/Hip Ratio on Risk of Breast Cancer by Joint Estrogen and Progestogen Receptor Status: Results from a Case-Control Study in Northern and Eastern China and Implications for Chemoprevention

Wang, Fei; Liu, Li Yuan; Cui, Shude; Tian, Fei; Zhang, Fan; Geng, Cuizhi; Cao, Xuchen; Yang, Zhenlin; Wang, Xiang; Liang, Hong; Shu, Wang; Jiang, Hongchuan; Duan, Xuening; Wang, Haibo; Li, Guolou; Wang, Qitang; Zhang, Jianguo; Jin, Feng; Tang, Jinhai; Li, Liang; Zhu, Shuchai; Zuo, Wenqi; Ma, Zhongbing; Zhou, Fei; Xiang, Yuzhi; Shen, Shuohao; Yu, Zhengping

doi:10.1634/theoncologist.2017-0148

Cited by 35 publications

(39 citation statements)

References 57 publications

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“…Body Mass Index is an independent factor for diabetes . And for Asians in United States, the risk of type 2 diabetes is very high when BMI is over 25, but for Whites, the same risk need BMI over 27.…”

Section: Discussionmentioning

confidence: 99%

“…Traditional views thought diabetes especially type 2 diabetes was associated with increased risk of breast cancer, because of higher body mass index (BMI). Our previous research showed that diabetes is an independent factor for risk of breast cancer rather than BMI . Nevertheless, there were few breast patients with diabetes 1 that might be accounted for shorter life span of patients or its lower BMI.…”

Section: Introductionmentioning

confidence: 97%

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Long non‐coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes

Chen

Shi

Zhang

et al. 2020

Clinical Laboratory Analysis

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Background In previous research, we found diabetes rather than obesity was an independent risk factor of breast cancer. However, why diabetes could lead to increased risk of breast cancer patients remains elusive. Long non‐coding RNAE330013P06 has been shown to be upregulated in diabetes, and long non‐coding RNAs generally promote progression of cancer. Methods About 200 specimens of breast patients were obtained in previous clinical trial; 34 samples diagnosed as type 2 diabetes in breast cancer patient were enrolled in this research. Blood samples from 36 patients diagnosed as breast cancer without diabetes; 35 diabetic patients and 35 healthy peoples were obtained as control. All blood samples were measured by quantitative real‐time PCR (qRT‐PCR). Invasion and migration were tested by Transwell assay. Cell proliferation assay was tested by CCK‐8. Protein analysis was determined by Western blot. Results Compared with breast cancer patients without diabetes, diabetic patients without breast cancer and healthy peoples, LncRNAE330013P06 was upregulated in breast cancer patient with diabetes. Furthermore, of 34 breast patients, high LncRNAE330013P06 expression was significantly associated with family history, tumor‐node‐metastasis stage and lymph node metastasis. E33 promoted cancer cell growth in vitro via downregulation of P53. Conclusion Upregulation of LncRNAE330013P06 driven by type 2 diabetes is one of the factors which promoted progression of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Long non‐coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes

Chen

Shi

Zhang

et al. 2020

Clinical Laboratory Analysis

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“…Obese women with larger amounts of subcutaneous fat, as measured by BMI, may have a significantly higher risk of developing hormone receptorpositive breast cancer. In contrast, larger amounts of visceral fat, indicated by a high waist-to-hip ratio, may be associated with a greater risk of developing hormone receptor-negative breast cancer, independent of BMI [17].…”

Section: Excessive Body Weight Distribution Of Fat Mass Insulin Sigmentioning

confidence: 95%

“…Case-control studies suggest that a woman's body fat distribution may influence the hormone receptor status of the breast cancer she is susceptible to [17]. Both general and central obesity have been associated with greater breast cancer risk [11].…”

Section: Excessive Body Weight Distribution Of Fat Mass Insulin Sigmentioning

confidence: 99%

Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Lammert

Grill

Kiechle³

2018

Breast Care

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Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

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“…Breast cancer patients were recruited from 22 hospitals in 11 provinces or municipalities in northern and eastern China from April 2012 to April 2013, as described previously (17,18). Han Chinese women newly diagnosed with primary breast cancer con rmed by histology and aged from 25 to 70 years were included in this study.…”

Section: Recruitmentmentioning

confidence: 99%

Relationship of Lifestyle Habits to Health-Related Quality of Life of Recently Diagnosed Breast Cancer Between Younger and Older Women in China

Zheng

Cui

Jia

et al. 2020

Preprint

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Background: Breast cancer is the most common cancer among women in China. Hence, how best to live with and improve the health-related quality of life (HRQoL) of this growing population of women is thus becoming of great public health importance. The aim of the study was to evaluate the relationship of lifestyle habits to HRQoL among younger and older women who were initially diagnosed with breast cancer within the first two weeks, determine the contribution of lifestyle habits factors on HRQoL.Methods: A multi-center, hospital-based, case control study was conducted among breast cancer women from 22 hospitals in 11 provinces or municipalities in northern and eastern China from April 2012 to April 2013. The Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) simplified Chinese version 4 was used to measure HRQoL. Chi-square test, ANOVA and Multivariable generalized linear models were conducted to verify differences in HRQoL between two groups and to evaluate the contribution of lifestyle habits factors ( including smoking, passive smoking, alcohol intake, Tea, Coffee, Sleep satisfaction, Current life satisfaction, Physical activity, BMI) on HRQoL of breast cancer patients.Results: 1199 eligible breast cancer patients were used for analysis. Younger women (age < 50 years) appeared to show lower scores than older women (age ≥ 50 years) in HRQoL subscales including emotional well being (p = 0.003), functional well being (p = 0.006), breast cancer subscale (p = 0.038), and FACT-B Total scores (p = 0.028). Tea and alcohol consumption, very satisfied with sleep and current life were the strongest predictors of higher HRQoL in younger group. Meanwhile, no coffee consumption, frequent participation in physical activities, high sleep satisfaction and current life satisfaction were the key predictors of higher HRQoL in older breast cancer women.Conclusion: The relationship of the nine lifestyle habit items to HRQoL were different between younger and older women. Associated variable of low HRQoL can help clinicians take intervention early in order to improve the prognosis of breast cancer patients.

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Distinct Effects of Body Mass Index and Waist/Hip Ratio on Risk of Breast Cancer by Joint Estrogen and Progestogen Receptor Status: Results from a Case-Control Study in Northern and Eastern China and Implications for Chemoprevention

Cited by 35 publications

References 57 publications

Long non‐coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes

Long non‐coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes

Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Relationship of Lifestyle Habits to Health-Related Quality of Life of Recently Diagnosed Breast Cancer Between Younger and Older Women in China

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