Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in mice

DeVito, Loren M.; Eichenbaum, Howard

doi:10.1016/j.bbr.2009.09.014

Cited by 135 publications

(97 citation statements)

References 37 publications

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“…Wilding and Rugg (1996) suggest that this late prefrontal old-new effect reflects the search and retrieval of contextual information relating to the studied stimuli, and that this ERP may be associated with the retrieval of episodic memory. This interpretation is consistent with data from studies using functional magnetic resonance imaging (fMRI), which has implicated a role for the right prefrontal cortex in episodic memory (Buckner & Tulving, 1995;Wagner, Desmond, Glover & Gabrieli, 1998;DeVito & Eichenbaum, 2010). Given that successful non-target recognition requires the participant to respond 'Other' to items that were not presented in their target colour, correct exclusion of a nontarget may be achieved by one of two strategies.…”

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confidence: 81%

Atypical Neurophysiology Underlying Episodic and Semantic Memory in Adults with Autism Spectrum Disorder

Massand

Bowler

2013

J Autism Dev Disord

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent repository link:http://openaccess.city.ac.uk/5378/ Link to published version: http://dx.doi.org/10.1007/s10803-013-1869-9Copyright and reuse: City Research Online aims to make research outputs of City, University of London available to a wider audience. Copyright and Moral Rights remain with the author(s) and/or copyright holders. URLs from City Research Online may be freely distributed and linked to. It is now generally agreed that there are 5 separate, but interacting memory systems (Nadel, 1992;Squire, 2004), the procedural memory system, the perceptual representation system, the working memory system, the semantic memory system and, the episodic memory system. The procedural and the perceptual representation system, share the features that they are considered non-declarative, non-conscious and implicit forms of memory, whilst the working memory system, semantic system and episodic system share the common attribute that they are open to consciousness, explicit and declarative memory systems. Declarative memory allows the cognitive registering of relations between objects and events (Tulving, 1985). The working memory system (Baddeley & Hitch, 1974) is different from the semantic and episodic memory systems in that it reflects a short-term, temporary storage for various types of information (e.g., auditory and visual information). The episodic and semantic memory systems are thought to be the most developed of the five human memory systems because they are open to conscious awareness (Schacter & Tulving, 1994). Semantic memory is the memory system responsible for timeless facts, such as the boiling point of water (and is context-free), whilst episodic memory is responsible for personally experienced andRemembered events that allow an individual to re-experience an event from the past (and is context-rich).Research in recent decades has highlighted a characteristic profile of memory abilities in Autism Spectrum Disorder (ASD), (see Bowler & Gaigg, 2008;Boucher, Mayes & Bigham, 2012, for reviews). In general, high functioning individuals with ASD show preserved semantic memory. Evidence for this is borne out of studies that have investigated immediate memory, cued recall and recognition in ASD (Boucher & Bowler, 2008; Bowler, Matthews & Gardiner, 2007;Boucher and Lewis, 1989). By contrast, they show some impairment on measures of episodic memory, including tests such as free recall (Smith et al., 2007;Boucher & Warrington, 1976), and significantly diminished memory for personally experienced events (Bruck, London, Landa & Goodman, 2007; Crane & Goddard, 2008;Tanweer, Rathbone & Souchay, 2010). They especially fail to use semantic relations amongst studied items to aid free recall (Bowler et al., 1997) and fail to learn as rapidly as comparison participants when the task involves multiple trials (Bowler, Gaigg & Gardiner, 2008b; Bowler, Mottron & Limoges, 2009). The recall/recognit...

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supporting

confidence: 81%

Atypical Neurophysiology Underlying Episodic and Semantic Memory in Adults with Autism Spectrum Disorder

Massand

Bowler

2013

J Autism Dev Disord

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“…Novel object recognition and object location memory involve the hippocampus (Dere et al 2007;Manns and Eichenbaum 2009;DeVito and Eichenbaum 2010). Hippocampal lesions impaired object recognition when the test was conducted in a complex environment, but had no effect when the spatial and contextual cues were minimized (Winters et al 2004;Forwood et al 2005), indicating that the hippocampus is important for processing spatial cues surrounding the objects.…”

Section: Discussionmentioning

confidence: 99%

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks

et al. 2015

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Chromosomal 16p11.2 deletion syndrome frequently presents with intellectual disabilities, speech delays, and autism. Here we investigated the Dolmetsch line of 16p11.2 heterozygous (+/2) mice on a range of cognitive tasks with different neuroanatomical substrates. Robust novel object recognition deficits were replicated in two cohorts of 16p11.2+/2 mice, confirming previous findings. A similarly robust deficit in object location memory was discovered in +/2, indicating impaired spatial novelty recognition. Generalizability of novelty recognition deficits in +/2 mice extended to preference for social novelty. Robust learning deficits and cognitive inflexibility were detected using Bussey-Saksida touchscreen operant chambers. During acquisition of pairwise visual discrimination, +/2 mice required significantly more training trials to reach criterion than wild-type littermates (+/+), and made more errors and correction errors than +/+. In the reversal phase, all +/+ reached criterion, whereas most +/2 failed to reach criterion by the 30-d cutoff. Contextual and cued fear conditioning were normal in +/2. These cognitive phenotypes may be relevant to some aspects of cognitive impairments in humans with 16p11.2 deletion, and support the use of 16p11.2+/2 mice as a model system for discovering treatments for cognitive impairments in 16p11.2 deletion syndrome.Recurrent heterozygous deletions of a 600-kb segment on human chromosome 16 is found in 0.4% of individuals with intellectual disability (Bijlsma et al. 2009;Hanson et al. 2015) and 0.6% of individuals with autism (Marshall et al. 2008;Weiss et al. 2008;Walsh and Bracken 2011). 16p11.2 deletion syndrome presents with a range of mild-to-severe cognitive impairments, with IQ scores averaging 2 SDs lower than controls, and a confirmed diagnosis of autism in 15% of affected individuals (Hanson et al.

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“…The task design originated from previous studies that employed behavioral exploration preferences to investigate episodic-like memory in rodents Kart-Teke et al 2006DeVito and Eichenbaum 2010;Davis et al 2013a,b;Inostroza et al 2013a,b). The episodic nature of our task was further enhanced by using unique faces that were presented in a unique spatio-temporal context.…”

Section: Discussionmentioning

confidence: 99%

Sleep benefits in parallel implicit and explicit measures of episodic memory

et al. 2014

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Research in rats using preferences during exploration as a measure of memory has indicated that sleep is important for the consolidation of episodic-like memory, i.e., memory for an event bound into specific spatio-temporal context. How these findings relate to human episodic memory is unclear. We used spontaneous preferences during visual exploration and verbal recall as, respectively, implicit and explicit measures of memory, to study effects of sleep on episodic memory consolidation in humans. During encoding before 10-h retention intervals that covered nighttime sleep or daytime wakefulness, two groups of young adults were presented with two episodes that were 1-h apart. Each episode entailed a spatial configuration of four different faces in a 3 × 3 grid of locations. After the retention interval, implicit spatio-temporal recall performance was assessed by eye-tracking visual exploration of another configuration of four faces of which two were from the first and second episode, respectively; of the two faces one was presented at the same location as during encoding and the other at another location. Afterward explicit verbal recall was assessed. Measures of implicit and explicit episodic memory retention were positively correlated (r ¼ 0.57, P , 0.01), and were both better after nighttime sleep than daytime wakefulness (P , 0.05). In the sleep group, implicit episodic memory recall was associated with increased fast spindles during nonrapid eye movement (NonREM) sleep (r ¼ 0.62, P , 0.05). Together with concordant observations in rats our results indicate that consolidation of genuinely episodic memory benefits from sleep.

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Distinct contributions of the hippocampus and medial prefrontal cortex to the “what–where–when” components of episodic-like memory in mice

Cited by 135 publications

References 37 publications

Atypical Neurophysiology Underlying Episodic and Semantic Memory in Adults with Autism Spectrum Disorder

Atypical Neurophysiology Underlying Episodic and Semantic Memory in Adults with Autism Spectrum Disorder

16p11.2 Deletion mice display cognitive deficits in touchscreen learning and novelty recognition tasks

Sleep benefits in parallel implicit and explicit measures of episodic memory

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