Distinct cognitive components and their neural substrates underlying praxis and language deficits following left hemisphere stroke

Schmidt, Claudia C.; Achilles, Elisabeth I.S.; Fink, Gereon R.; Weiss, Peter H.

doi:10.1016/j.cortex.2021.11.004

Cited by 12 publications

(16 citation statements)

References 87 publications

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“…103,132 More recent studies have used PCA to described apraxic deficits observed in patients. 105,134 In a preliminary study, 40 chronic stroke patients tested on 8 apraxia tasks, identified 2 core components underlying apraxia. 134 These involved action selection and semantic control.…”

Section: Challenges and Emerging Work Diagnosismentioning

confidence: 99%

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Rounis

Binkofski

2023

Stroke

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Stroke is a leading cause of disability worldwide. Limb apraxia is a group of higher order motor disorders associated with greater disability and dependence after stroke. Original neuropsychology studies distinguished separate brain pathways involved in perception and action, known as the dual stream hypothesis. This framework has allowed a better understanding of the deficits identified in Limb Apraxia. In this review, we propose a hierarchical organization of this disorder, in which a distinction can be made between several visuomotor pathways that lead to purposeful actions. Based on this, executive apraxias (such as limb kinetic apraxia) cause deficits in executing fine motor hand skills, and intermediate apraxias (such as optic ataxia and tactile apraxia) cause deficits in reaching to grasp and manipulating objects in space. These disorders usually affect the contralesional limb. A further set of disorders collectively known as limb apraxias include deficits in gesture imitation, pantomime, gesture recognition, and object use. These deficits are due to deficits in integrating perceptual and semantic information to generate complex movements. Limb apraxias are usually caused by left-hemisphere lesions in right-handed stroke patients, affecting both limbs. The anterior- to posterior-axis of brain areas are disrupted depending on the increasing involvement of perceptual and semantic processes with each condition. Lower-level executive apraxias are linked to lesions in the frontal lobe and the basal ganglia, while intermediate apraxias are linked to lesions in dorso-dorsal subdivisions of the dorsal fronto-parietal networks. Limb apraxias can be caused by lesions in both dorsal and ventral subdivisions including the ventro-dorsal stream and a third visuomotor pathway, involved in body schema and social cognition. Rehabilitation of these disorders with behavioral therapies has aimed to either restore perceptuo-semantic deficits or compensate to overcome these deficits. Further studies are required to better stratify patients, using modern neurophysiology and neuroimaging techniques, to provide targeted and personalized therapies for these disorders in the future.

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Section: Challenges and Emerging Work Diagnosismentioning

confidence: 99%

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Rounis

Binkofski

2023

Stroke

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“…The PMv is involved the planning and implementation of compound or multi-step tool use actions (Chao & Martin, 2000; Garcea & Buxbaum, 2019; Grafton et al, 1997) and in the sequencing of action (De Renzi et al, 1983; Harrington & Haaland, 1992). Whereas impaired tool use pantomiming in apraxia has been associated with lesions to each of these areas (Dressing et al, 2018; Garcea et al, 2013; Goldenberg, 2009; Martin et al, 2016; Osiurak et al, 2021; Randerath et al, 2009; Schmidt et al, 2022; Weiss et al, 2001), susceptibility to grasp-on-use interference has been linked to lesions involving the left SMG, PMv/IFG, insula, and underlying white matter, including the superior longitudinal fasciculus (Garcea et al, 2019; Watson & Buxbaum, 2015). In a study of LCVA participants, the degree of grasp-on-use interference was associated with reduced resting state functional connectivity between the left SMG and the left PMv (Watson et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke

Garcea

Buxbaum

2022

Preprint

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The ability to select between potential actions is central to the complex process of tool use. After left hemisphere stroke, individuals with limb apraxia make more hand action errors when gesturing the use of tools with conflicting hand actions for grasping-to-move and use (e.g., screwdriver) relative to tools that are grasped-to-move and used with the same hand action (e.g., hammer). Prior research indicates that this grasp-use interference effect is driven by abnormalities in the competitive action selection process. The goal of this project was to determine whether common mechanisms and neural substrates support the competitive selection of task-appropriate responses in both tool and non-tool domains. If so, the grasp-use interference effect in a tool use gesturing task should be correlated with response interference effects in the classic Eriksen flanker and Simon tasks, and at least partly overlapping neural regions should subserve the 3 tasks. Sixty-four left hemisphere stroke survivors (33 with apraxia) participated in the tool- and non-tool interference tasks and underwent T1 anatomical MRI. There were robust grasp-use interference effects (grasp-use conflict test) and response interference effects (Eriksen flanker and Simon tasks), but these effects were not correlated. Lesion-symptom mapping analyses showed that lesions to the left inferior parietal lobule, ventral premotor cortex, and insula were associated with grasp-use interference. Lesions to the left inferior parietal lobule, postcentral gyrus, insula, caudate, and putamen were associated with response interference in the Eriksen flanker task. Lesions to the left caudate and putamen were also associated with response interference in the Simon task. Our results suggest that the selection of hand posture for tool use is mediated by distinct cognitive mechanisms and partly distinct neuroanatomic substrates from those mapping a stimulus to an appropriate motor response in non-tool domains.

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“…Patients scoring 76 points or less are considered apraxic. Besides the published manual ( Weiss et al, 2013 ), please see Dovern et al, 2012 , Schmidt et al, 2022 for further details on the KAS, including its quality criteria and testing procedure.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, partial neuroanatomical distinctions have been reported for bucco-facial and limb apraxia ( Scandola et al, 2021 ). Furthermore, principal component analysis of behavioural and lesion data of 91 LH stroke patients revealed differential lesion correlates for the imitation of bucco-facial gestures versus arm/hand and finger gestures ( Schmidt et al, 2022 ). In this study, lesions affecting the left basal ganglia and white matter tracts were linked to imitating bucco-facial gestures, while lesions affecting the left IPL and the precentral gyrus were associated with imitating arm/hand gestures.…”

Section: Introductionmentioning

confidence: 99%

Gesture meaning modulates the neural correlates of effector-specific imitation deficits in left hemisphere stroke

Kleineberg

Schmidt²,

Richter

et al. 2023

NeuroImage: Clinical

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Distinct cognitive components and their neural substrates underlying praxis and language deficits following left hemisphere stroke

Cited by 12 publications

References 87 publications

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Limb Apraxias: The Influence of Higher Order Perceptual and Semantic Deficits in Motor Recovery After Stroke

Mechanisms and neuroanatomy of response selection in tool and non-tool action tasks: Evidence from left-hemisphere stroke

Gesture meaning modulates the neural correlates of effector-specific imitation deficits in left hemisphere stroke

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