Distinct clinicopathological phenotype of hepatocellular carcinoma with ethoxybenzyl-magnetic resonance imaging hyperintensity: association with gene expression signature

Miura, Tomoya; Ban, Daisuke; Tanaka, Shinji; Mogushi, Kaoru; Kudo, Atsushi; Matsumura, Satoshi; Mitsunori, Yusuke; Ochiai, Takanori; Tanaka, Hiroshi; Tanabe, Minoru

doi:10.1016/j.amjsurg.2015.03.027

Cited by 27 publications

(26 citation statements)

References 29 publications

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“…16,31,34 This relationship held for other studies of GBM which did not utilize VASARI. One study of breast cancer found the location, lymph node and stromal patterns to be significant imaging features with genomic data, 21 while another study of HCC focused on the intensity of the tumour in the hepatobiliary-phase MR. 39 There was relative uniformity for the computationally derived imaging features (Table 3). 9, For CT, tumour intensity, texture and shape were the most commonly extracted features, especially for NSCLC.…”

Section: Imaging Features and Extractionmentioning

confidence: 99%

“…8 studies used data from The Cancer Genome Atlas (TCGA) and/or The Cancer Imaging Archive (TCIA); 1,16,23,27,32,34,38,41 2 studies were multi-institutional; 9,19 and the remaining 17 studies used local institutional data. 15,17,18,[20][21][22][24][25][26]28,30,31,33,[35][36][37]39,40 26 out of 27 studies were retrospective in design. The number of patients ranged from 10 to 104 patients, with a median of 38 patients.…”

Section: Published Studies Using a Radiogenomic Approach In Cancer Rementioning

confidence: 99%

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Imaging genomics in cancer research: limitations and promises

Bai

Lee

Yang

et al. 2016

BJR

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Recently, radiogenomics or imaging genomics has emerged as a novel high-throughput method of associating imaging features with genomic data. Radiogenomics has the potential to provide comprehensive intratumour, intertumour and peritumour information non-invasively. This review article summarizes the current state of radiogenomic research in tumour characterization, discusses some of its limitations and promises and projects its future directions. Semiradiogenomic studies that relate specific gene expressions to imaging features will also be briefly reviewed.

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Section: Imaging Features and Extractionmentioning

confidence: 99%

Section: Published Studies Using a Radiogenomic Approach In Cancer Rementioning

confidence: 99%

Imaging genomics in cancer research: limitations and promises

Bai

Lee

Yang

et al. 2016

BJR

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“…The major transporters of Gd-EOB-DTPA are organic anion transporter polypeptides OATP1B1/-1B3 (the uptake transporter) at the sinusoidal membrane, multi-drug resistance-associated proteins MRP2 (the excretion transporter) at the canalicular membrane and MRP3 (the excretion transporter) at the sinusoidal membrane. It was revealed that the enhancement ratio of HCCs in hepatobiliary phase is positively correlated with expression levels of OATP8 (synonymous with OATP1B3) and MRP3 [4], and OATP1B3 was confirmed as the most important uptake transporter of Gd-EOB-DTPA [5,6]. Combined with OATP1B1 and/or OATP1B3 expression, two patterns of MRP2 expression contributed to high enhancement, decreased expression at the canalicular membrane and increased expression at the luminal membrane of pseudo glands [7], which result in accumulation of Gd-EOB-DTPA in cytoplasm of tumour cells or lumina of pseudo glands.…”

Section: Discussionmentioning

confidence: 99%

“…Combined with OATP1B1 and/or OATP1B3 expression, two patterns of MRP2 expression contributed to high enhancement, decreased expression at the canalicular membrane and increased expression at the luminal membrane of pseudo glands [7], which result in accumulation of Gd-EOB-DTPA in cytoplasm of tumour cells or lumina of pseudo glands. The iso-or hyperintense HCCs also have some histopathologic features, it was reportedthese HCCs tended to be of lower histologic grade [2,6,8,9], a pseudo glandular proliferation pattern [4] and bile accumulation [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…Poor spatial resolution results in low sensitivity for small lesions, the detection rate was only 13% of extrahepatic HCC metastases that are ≤10 mm [11]. The extrahepatic metastases which were hyperintense in hepatobiliary phase may be of lower histologic grade [2,6,8,9] which resulted in low uptake of 18 F-FDG. Bone metastases from HCC are often osteolytic, this resulted in low sensitivity for most metastases from HCC on BS [12].…”

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confidence: 99%

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Uptake of Gd-EOB-DTPA in Bone and Splenic Metastases from Hepatocellular Carcinoma: A Case Study

Chen¹

2017

Austin J Gastroenterol

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We present the case of bone and splenic metastases from hepatocellular carcinoma (HCC), which showed uptake of gadolinium-ethoxybenzyldiethylenetriaminepentaacetic acid (Gd-EOB-DTPA) on magnetic resonance imaging (MRI). To the best of our knowledge, this is the first case of bone and splenic metastases from HCC that demonstrated uptake of Gd-EOB-DTPA in the hepatobiliary phase.Keywords: Gd-EOB-DTPA; HCC; Bone metastases; Splenic metastases Case PresentationA 65-year-old man presented with a 3-month history of dull pain on the right side of the chest. A liver tumour was found on routine abdominal magnetic resonance imaging (MRI), with elevated alpha-fetoprotein (AFP) at 498 ng/ml [normal range<8 ng/ml]. Gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhanced MRI was then performed. Unenhanced MRI displayed an ill-defined heterogeneous mass, which was hyperintense on T2-weighted imaging (T2WI) and hypointense on T1-weighted imaging (T1WI), in the right lobe of the liver. After the injection of Gd-EOB-DTPA, the lesion showed heterogeneous enhancement in the arterial phase and washout in the portal venous and equilibrium phases. In the hepatobiliary phase, a large part of the lesion appeared hypointense, and multiple hyperintense nodules within the lesion were observed (Figure 1). Several hypointense satellite lesions with well-defined margin were observed only in the hepatobiliary phase.An ill-defined mass with osteolytic destruction around the right seventh rib was noted; it had a similar enhancement pattern with the liver lesion and appeared hypointense in the hepatobiliary phase ( Figure 1). Patchy, nodular lesions (≤10 mm) were observed in several thoracolumbar vertebrae (T5, T8, T9, T11, L1 and L2), in the right tenth rib and left ninth rib. These patchy, nodular lesions appeared hyperintense on T2WI, less clear on unenhanced T1WI, and showed markedly enhancement during the arterial and portal venous phases, with persistent enhancement in hepatobiliary phase (Figure 1). There were three splenic nodules measuring 7-10 mm in diameter, which were isointense on unenhanced T1WI and T2WI, but showed persistent enhancement from the arterial phase to hepatobiliary phase.As part of the staging process, uptake ( Figure 1). The spleen showed normal glucose uptake, without displaying the nodules that were found on the Gd-EOB-DTPAenhanced MRI. The BS images showed anomalous radioactive concentration in the right seventh and tenth ribs and T5 (Figure 2).For this patient, a diagnosis of HCC was made based on the imaging findings, the presence of hepatitis B infection and elevated AFP. The BS findings and osteolytic lesions on 18 F-FDGPET/CT suggested bone metastases. We doubt that the splenic lesions to be metastases from HCC for the patient underwent physical examination yearly and abdominal ultrasound didn't find any space-occupying lesion in the spleen before. Considering the advanced stage, surgical resection was not an option for this patient; instead, he underwent transcatheter arteria...

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