Distinct Clinical and Prognostic Features of Infiltrating Lobular Carcinoma of the Breast: Combined Results of 15 International Breast Cancer Study Group Clinical Trials

Abstract

ILC is more than a histologic variant of breast cancer. The diagnosis of ILC carries distinct prognostic and biologic implications.

Effect of neoadjuvant anthracycline–taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the GeparTrio study

“…those with a triple negative phenotype which underlines the fact that the triple negative is a mixed population of different tumor types, where those without pCR have an extremely poor prognosis [17,18]. A different biological behavior between invasive lobular and invasive ductal breast carcinomas has been described for the adjuvant and neoadjuvant setting [19][20][21]. In our study a total of 277 patients with lobular histology were evaluated and confirmed that this subtype is less sensitive to chemotherapy and will only benefit if other biomarkers defining aggressive behavior as grade 3 or ER/PgR negativity were apparent.…”

Lobular and non-lobular breast cancers differ regarding axillary lymph node metastasis: a cross-sectional study on 4,292 consecutive patients

“…The diagnosis of ILC carries distinct prognostic and biologic implications. Differences in clinical behaviour between ILCs and invasive ductal carcinomas have been reported [2][3][4][5][6][7]. ILCs have a propensity for multifocal and multicentric distribution but also for bilateralism and a particular pattern of metastatic spread.…”

Original paper Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

“…There are histological subtypes with excellent prognosis: tubular carcinoma, cribriform carcinoma, adenoid-cystic carcinoma, pure mucinous carcinoma [16], as well as subtypes associated with a worse prognosis, frequently diagnosed in a metastatic stage: micropapillary carcinoma, inflammatory carcinoma, NST carcinoma, lobular carcinoma [16,29,30]. Our study revealed that, when present in association with heterogeneous primary tumours, axillary lymph node metastases may present heterogeneous histological types (in 33.33% of cases).…”