Distinct Causal Influences of Parietal Versus Frontal Areas on Human Visual Cortex: Evidence from Concurrent TMS-fMRI

Ruff, Christian C.; Bestmann, Sven; Blankenburg, Felix; Bjoertomt, Otto; Josephs, Oliver; Weiskopf, Nikolaus; Deichmann, R.; Driver, Jon

doi:10.1093/cercor/bhm128

Cited by 287 publications

(286 citation statements)

References 86 publications

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“…To test the hypothesis, we used dynamic causal modeling analyses to determine the connectivity structure between left TPJ, IFG, and FEF. FEF was chosen as the representative "dorsal network" region in these models because of the substantial evidence for FEF in attentional control O'Shea et al, 2004;Ruff et al, 2006Ruff et al, , 2008Buschman and Miller, 2007;Bressler et al, 2008).…”

Section: Dcm Resultsmentioning

confidence: 99%

Contextual Knowledge Configures Attentional Control Networks

DiQuattro¹,

Geng²

2011

J. Neurosci.

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Contextual cues are predictive and provide behaviorally relevant information; they are not the main objective of the current task but can make behavior more efficient. Using fMRI, we investigated the brain networks involved in representing contextual information and translating it into an attentional control signal. Human subjects performed a visual search task for a low-contrast target accompanied by a single non-target that was either perceptually similar or more salient (i.e., higher contrast). Shorter reaction times (RTs) and higher accuracy were found on salient trials, suggesting that the salient item was rapidly identified as a non-target and immediately acts as a spatial "anti-cue" to reorient attention to the target. The relative saliency of the non-target determined BOLD responses in the left temporoparietal junction (TPJ) and inferior frontal gyrus (IFG). IFG correlated with RT specifically on salient non-target trials. In contrast, bilateral dorsal frontoparietal regions [including the frontal eye fields (FEFs)] were correlated with RT in all conditions. Effective connectivity analyses using dynamic causal modeling found an excitatory pathway from TPJ to IFG to FEF, suggesting that this was the pathway by which the contextual cue was translated into an attentional control signal that facilitated behavior. Additionally, the connection from FEF to TPJ was negatively modulated during target-similar trials, consistent with the inhibition of TPJ by dorsal attentional control regions during top-down serial visual search. We conclude that left TPJ and IFG form a sensory-driven network that integrates contextual knowledge with ongoing sensory information to provide an attentional control signal to FEF.

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Section: Dcm Resultsmentioning

confidence: 99%

Contextual Knowledge Configures Attentional Control Networks

DiQuattro¹,

Geng²

2011

J. Neurosci.

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“…The application of concurrent TMS‐fMRI is challenged by numerous technical difficulties, a few of which have already been addressed in other works (Bestmann et al, 2004; Ruff et al, 2008). A technical issue which was not previously described is that we observed short deflections (one sample) in baseline activity in a single slice in the vicinity of the TMS coil in EPI volumes during inspection of the BOLD signal (section “Data analysis”).…”

Section: Discussionmentioning

confidence: 99%

A novel concurrent TMS‐fMRI method to reveal propagation patterns of prefrontal magnetic brain stimulation

Vink

Mandija

Petrov

et al. 2018

Human Brain Mapping

101

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Major depressive disorder (MDD) is a severe mental disorder associated with high morbidity and mortality rates, which remains difficult to treat, as both resistance and recurrence rates are high. Repetitive transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) provides a safe and effective treatment for selected patients with treatment‐resistant MDD. Little is known about the mechanisms of action of TMS provided to the left DLPFC in MDD and we can currently not predict who will respond to this type of treatment, precluding effective patient selection. In order to shed some light on the mechanism of action, we applied single pulse TMS to the left DLPFC in 10 healthy participants using a unique TMS‐fMRI set‐up, in which we could record the direct effects of TMS. Stimulation of the DLPFC triggered activity in a number of connected brain regions, including the subgenual anterior cingulate cortex (sgACC) in four out of nine participants. The sgACC is of particular interest, because normalization of activity in this region has been associated with relief of depressive symptoms in MDD patients. This is the first direct evidence that TMS pulses delivered to the DLPFC can propagate to the sgACC. The propagation of TMS‐induced activity from the DLPFC to sgACC may be an accurate biomarker for rTMS efficacy. Further research is required to determine whether this method can contribute to the selection of patients with treatment resistant MDD who will respond to rTMS treatment.

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“…A promising avenue for future studies will be to combine TMS with fMRI (Ruff et al, 2006(Ruff et al, , 2008Sack et al, 2007), revealing the consequences of SMG/IPS stimulation on target-related activity in retinotopic visual cortex (V1-V5). In particular, the present results raise the question of whether stimulating the aIPS would yield qualitatively different effects in the visual cortex during spatial and color-based selection, consistent with recent evidence that attention depends on top-down connections between parietal and occipital areas (Saalmann et al, 2007).…”

Section: Discussionmentioning

confidence: 99%