Distinct Brain Dynamic Functional Connectivity Patterns in Schizophrenia Patients With and Without Auditory Verbal Hallucinations

Zhang, Yao; Wang, Jia; Lin, Xin; Yang, Min; Qi, Shun; Wang, Yuhan; Liang, Wei; Lu, Huijie; Zhang, Yan; Zhai, Wei; Hao, Wanting; Cao, Yang; Huang, Peng; Guo, Jianying; Hu, Xuehui; Lee, Seonjoo

doi:10.3389/fnhum.2022.838181

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…We then calculated the correlations between the time courses of each pair of ROIs within RS-fMRI scan windows to determine whole-brain functional connectivity. In line with previous research (J. Li et al, 2019 ; Zhang et al, 2022 ), the resting state data of 230 TRs were divided into 37 windows at the setting of 50 TRs (100 s) as the window length and 5 TRs (10 s) as the step size. Therefore, the time series generated 37 functional connectivity matrices of 114 × 114 for each participant.…”

Section: Methodsmentioning

confidence: 99%

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The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults

Jin,

Xu,

et al. 2023

European Journal of Psychotraumatology

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Background: Childhood emotional neglect (CEN) confers a great risk for developing multiple psychiatric disorders; however, the neural basis for this association remains unknown. Using a dynamic functional connectivity approach, this study aimed to examine the effects of CEN experience on functional brain networks in young adults. Method: In total, 21 healthy young adults with CEN experience and 26 without childhood trauma experience were recruited. The childhood trauma experience was assessed using the childhood trauma questionnaire (CTQ), and eligible participants underwent resting-state functional MRI. Sliding windows and k-means clustering were used to identify temporal features of large-scale functional connectivity states (frequency, mean dwell time, and transition numbers). Result: Dynamic analysis revealed two separate connection states: state 1 was more frequent and characterized by extensive weak connections between the brain regions. State 2 was relatively infrequent and characterized by extensive strong connections between the brain regions. Compared to the control group, the CEN group had a longer mean dwell time in state 1 and significantly decreased transition numbers between states 1 and 2. Conclusion: The CEN experience affects the temporal properties of young adults’ functional brain connectivity. Young adults with CEN experience tend to be stable in state 1 (extensive weak connections between the brain regions), reducing transitions between states, and reflecting impaired metastability or functional network flexibility.

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Section: Methodsmentioning

confidence: 99%

“…Referring to previous studies (Fiorenzato et al, 2019 ; Zhang et al, 2022 ), we next performed a cluster analysis for the CEN and HC groups separately to explore whether the two groups have a different optimal number of states.…”

Section: Methodsmentioning

confidence: 99%

The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults

Jin,

Xu,

et al. 2023

European Journal of Psychotraumatology

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“…So far, only a few researchers study the auditory hallucination mechanism of schizophrenia using the dFC method. Some studies underly the whole brain dynamic patterns with ICA, Zhang et al ( 39 ) have manifested that schizophrenia patients with AVH switched among several states using the dFC method, with the aberrant connectivity of language-related areas. However, there is no study on the dFC of the auditory-related regions in schizophrenia with AVH.…”

Section: Introductionmentioning

confidence: 99%

Altered dynamic functional connectivity of auditory cortex and medial geniculate nucleus in first-episode, drug-naïve schizophrenia patients with and without auditory verbal hallucinations

et al. 2022

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Background and objectiveAs a key feature of schizophrenia, auditory verbal hallucination (AVH) is causing concern. Altered dynamic functional connectivity (dFC) patterns involving in auditory related regions were rarely reported in schizophrenia patients with AVH. The goal of this research was to find out the dFC abnormalities of auditory related regions in first-episode, drug-naïve schizophrenia patients with and without AVH using resting state functional magnetic resonance imaging (rs-fMRI).MethodsA total of 107 schizophrenia patients with AVH, 85 schizophrenia patients without AVH (NAVH) underwent rs-fMRI examinations, and 104 healthy controls (HC) were matched. Seed-based dFC of the primary auditory cortex (Heschl's gyrus, HES), auditory association cortex (AAC, including Brodmann's areas 22 and 42), and medial geniculate nucleus (MGN) was conducted to build a whole-brain dFC diagram, then inter group comparison and correlation analysis were performed.ResultsIn comparison to the NAVH and HC groups, the AVH group showed increased dFC from left ACC to the right middle temporal gyrus and right middle occipital gyrus, decreased dFC from left HES to the left superior occipital gyrus, left cuneus gyrus, left precuneus gyrus, decreased dFC from right HES to the posterior cingulate gyrus, and decreased dFC from left MGN to the bilateral calcarine gyrus, bilateral cuneus gyrus, bilateral lingual gyrus. The Auditory Hallucination Rating Scale (AHRS) was significantly positively correlated with the dFC values of cluster 1 (bilateral calcarine gyrus, cuneus gyrus, lingual gyrus, superior occipital gyrus, precuneus gyrus, and posterior cingulate gyrus) using left AAC seed, cluster 2 (right middle temporal gyrus and right middle occipital gyrus) using left AAC seed, cluster 1 (bilateral calcarine gyrus, cuneus gyrus, lingual gyrus, superior occipital gyrus, precuneus gyrus and posterior cingulate gyrus) using right AAC seed and cluster 2 (posterior cingulate gyrus) using right HES seed in the AVH group. In both AVH and NAVH groups, a significantly negative correlation is also found between the dFC values of cluster 2 (posterior cingulate gyrus) using the right HES seed and the PANSS negative sub-scores.ConclusionsThe present findings demonstrate that schizophrenia patients with AVH showed multiple abnormal dFC regions using auditory related cortex and nucleus as seeds, particularly involving the occipital lobe, default mode network (DMN), and middle temporal lobe, implying that the different dFC patterns of auditory related areas could provide a neurological mechanism of AVH in schizophrenia.

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Abnormalities in electroencephalographic microstates among violent patients with schizophrenia

Lin

Li²,

Liu³

et al. 2023

Front. Psychiatry

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Schizophrenia is often associated with a remarkably increased risk of violence, which has become a public health concern and brought a great economic burden. Recent studies have reported changes in the electroencephalograms (EEG) of patients with schizophrenia. The evidence for an association between EEG and violence in patients with schizophrenia is not conclusive. This study aimed to investigate EEG microstates in violent patients with schizophrenia. Forty-three violent patients with schizophrenia (the VS group) and 51 non-violent patients with schizophrenia (the NVS group) were included, and their EEG microstates were recorded using 21-Channel EEG recordings. The two groups were compared for differences of four microstate classes (A–D) with regards to three microstate parameters (duration, occurrence, and coverage). Compared with the NVS group, the VS group exhibited increased duration, occurrence, and coverage of microstate class A and decreased occurrence of microstate class B. The VS group also had lower probabilities of transitions from “B to C” and from “C to B”, as compared with the NVS group. In addition, the MOAS score was positively correlated with the duration, occurrence, and coverage of microstate A. The present study found an abnormal pattern of EEG microstates in violent patients with schizophrenia, which might help clinicians identify patients with schizophrenia who might engaged in violence as well as develop intervention strategies at an early stage.

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Distinct Brain Dynamic Functional Connectivity Patterns in Schizophrenia Patients With and Without Auditory Verbal Hallucinations

Cited by 3 publications

References 32 publications

The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults

The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults

Altered dynamic functional connectivity of auditory cortex and medial geniculate nucleus in first-episode, drug-naïve schizophrenia patients with and without auditory verbal hallucinations

Abnormalities in electroencephalographic microstates among violent patients with schizophrenia

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