Distinct binding hotspots for natural and synthetic agonists of FFA4 from in silico approaches
Guillaume Patient,
Corentin Bedart,
Naim. A Khan
et al.
Abstract:FFA4 has gained interest in recent years since its deorphanization in 2005 and the characterization of the Free Fatty Acids receptors family for their therapeutic potential in metabolic disorders. The expression of FFA4 (also known as GPR120) in numerous organs throughout the human body makes this receptor a highly potent target, particularly in fat sensing and diet preference. This offers an attractive approach to tackle obesity and related metabolic diseases. Recent cryo‐EM structures of the receptor have pr… Show more
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