Distinct bacterial colonization patterns of Escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis

Newkirk, Marianna M.; Zbar, Ariella; Baron, Murray; Manges, Amee R.

doi:10.1093/rheumatology/keq088

Cited by 36 publications

(30 citation statements)

References 28 publications

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“…There is ongoing debate on whether RA may be initiated by an infectious microorganism,98 104 and many bacteria have been proposed in this capacity, such as Mycoplasma fermentans, 105 Escherichia coli 106 and Proteus mirabilis 107 108. This idea of ‘molecular mimicry’ has existed for at least a century, but has never been definitively proven 104.…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

McLean

Dieguez

Miller

et al. 2014

Gut

183

112

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The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus. There is emerging literature on the role of the microbiota in the pathogenesis of autoimmune disease, with clear and increasing evidence that changes in the microbiota are associated with some of these diseases. Examples include type 1 diabetes, coeliac disease and rheumatoid arthritis, and these contribute significantly to global morbidity and mortality. Understanding the role of the microbiota in autoimmune diseases may offer novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies. This review summarises the current status on the role of the microbiota in autoimmune diseases.

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Section: Rheumatoid Arthritismentioning

confidence: 99%

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

McLean

Dieguez

Miller

et al. 2014

Gut

183

112

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“…The presence of speciic Escherichia coli, Mycoplasma fermentans, and Klebsiella pneumonia in the gut has been associated with RF positivity and has been linked to inlammatory arthritis in many ethnic populations [16].…”

Section: The Oral Sepsis Hypothesismentioning

confidence: 99%

The Gut Microbiota and Inflammation in Rheumatoid Arthritis

Mohammed¹,

Elmakhzangy²

2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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Abstract"Mutualism" is a well-deined relationship that describes a form of cooperation between two living organisms of diferent species that ends up with a beneicial outcome for each one. Any disruption to such a relationship by an external trigger or a potential intruder puts at risk the well-being of both. In humans, oral and gut microbiota provide a noteworthy model of beneicial mutualism. Multiple recent evidences point to the possible pathologic consequences of a disruption to this ecosystem (altered microbiota proile or dysbiosis) on human well-being. The gut-joint axis found its clear way "Proof of Principle" in the pathogenesis of autoimmune rheumatic diseases including rheumatoid arthritis (RA), seronegative spondyloarthropathies, and Behcet's disease in a number of studies. Current therapeutic trends are directed towards the diverse biologic and immune-pathogenic factors involved in the disease process. Addressing dysbiosis in RA features an atractive future therapeutic target. In this chapter, authors aim to explore the recent evidences regarding the pathogenic role of "gut dysbiosis" in rheumatoid arthritis (RA), highlighting the spectrum of immune-pathogenic events that might contribute to disease evolution and inspecting future directives of research.

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“…On the one hand, there is much evidence that supports the association between RA and the intestinal microbiota; bacteria such as Mycoplasma fermentans [12], Escherichia coli [13], and Proteus mirabilis [14] have been reported to initiate the disease. On the other hand, it has been demonstrated that gastrointestinal and urogenital infections are associated with a significantly lowered risk of RA [15] and that patients with RA exhibit decreased gut microbial diversity compared with controls [16].…”

Section: Gastrointestinal Microbiota In Rheumatoid Arthritis Patientsmentioning

confidence: 99%

The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases

Ciccia

Ferrante

Guggino

et al. 2016

Best Practice & Research Clinical Rheumatology

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a b s t r a c tDysregulation of the intestinal epithelial barrier in genetically susceptible individuals may lead to both intestinal and extraintestinal autoimmune disorders. There is emerging literature on the role of microbiota changes in the pathogenesis of systemic rheumatic diseases such as rheumatoid arthritis, spondyloarthropathies, and connective tissue diseases. Although the role of the gastrointestinal tract in the pathogenesis of spondyloartropathies is well defined and many studies underline the importance of gastrointestinal inflammation in modulating local and systemic inflammation, the data are inconclusive regarding the effect of dysbiosis on rheumatoid arthritis and connective tissue diseases. This review aims to summarize current data on the role of the gastrointestinal involvement and intestinal microbiota in the pathogenesis of systemic rheumatic disease.

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Distinct bacterial colonization patterns of Escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis

Abstract: These studies link the type of colonizing bacteria in the gut and urine with the immune response (anti-bacterial and RF) in early-onset inflammatory arthritis and provide evidence for a role of the host-pathogen response in the aetiology of RF.

Cited by 36 publications

References 28 publications

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

Does the microbiota play a role in the pathogenesis of autoimmune diseases?

The Gut Microbiota and Inflammation in Rheumatoid Arthritis

The role of the gastrointestinal tract in the pathogenesis of rheumatic diseases

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