Distinct and dynamic myogenic populations in the vertebrate embryo

Buckingham, Margaret; Vincent, Stéphane

doi:10.1016/j.gde.2009.08.001

Cited by 188 publications

(193 citation statements)

References 71 publications

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“…Results were assessed for statistical significance by student's t-test (unpaired, two-tailed) and differences were considered statistically significant at P < 0.05. Asterisks in the histogram indicate the different P values: **P < 0.01 and ***P < 0.001. ously demonstrated that during embryogenesis Pax3 + progenitors of the dermomyotome give rise not only to myogenic cells, but also to several other mesoderm cell types, including dermal fibroblasts, endothelial cells 44,45, and, notably, to pericytes and smooth muscle of the dorsal aorta 25 . Thus, whereas all satellite cells appear to originate from somites 2 , the data presented here are not in contrast with this evidence, because other mesoderm progenitors, such as Pax3-expressing pericytes, also originate from somites.…”

Section: Discussionmentioning

confidence: 99%

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

Dellavalle¹,

Maroli

Covarello³

et al. 2011

Nat Commun

401

376

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skeletal muscle fibres form by fusion of mesoderm progenitors called myoblasts. After birth, muscle fibres do not increase in number but continue to grow in size because of fusion of satellite cells, the postnatal myogenic cells, responsible for muscle growth and regeneration. numerous studies suggest that, on transplantation, non-myogenic cells also may contribute to muscle regeneration. However, there is currently no evidence that such a contribution represents a natural developmental option of these non-myogenic cells, rather than a consequence of experimental manipulation resulting in cell fusion. Here we show that pericytes, transgenically labelled with an inducible Alkaline Phosphatase CreERT2, but not endothelial cells, fuse with developing myofibres and enter the satellite cell compartment during unperturbed postnatal development. This contribution increases significantly during acute injury or in chronically regenerating dystrophic muscle. These data show that pericytes, resident in small vessels of skeletal muscle, contribute to its growth and regeneration during postnatal life.

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Section: Discussionmentioning

confidence: 99%

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

Dellavalle¹,

Maroli

Covarello³

et al. 2011

Nat Commun

401

376

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“…Within the embryo, different muscle groups follow distinct developmental routes (Buckingham and Vincent 2009). Trunk and back muscles are derived directly from the primary myotome, which extends into the regions where the adult muscles will be located and form the adult muscular pattern.…”

Section: Skeletal Musclementioning

confidence: 99%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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“…They form heterodimers with E-protein family members and bind to a consensus DNA sequence, CANNTG, called E-box to activate transcription of muscle-specific genes (Berkes and Tapscott, 2005). Gene invalidation experiments in mice established that Myf5, Myod, and Mrf4 (Kassar- Duchossoy et al, 2004;Buckingham and Vincent, 2009) can be defined as myogenic determination factors. Furthermore, Myod, Myogenin, and Mrf4 participate to the activation of skeletal muscle gene expression during myogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

“…Development of embryonic and fetal muscle fibers in vertebrates takes place by the appearance of successive myogenic waves (Tajbakhsh, 2009). However, there are crucial differences between mammals and anamniote somitic myogenesis: in mammals, all muscle cells of the trunk and limbs derive from the dermomyotome (Buckingham and Vincent, 2009). This is not the case in Xenopus, because a dermomyotome-like structure develops after the appearance of the earliest muscle fibers (Grimaldi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Myogenic waves and myogenic programs during Xenopus embryonic myogenesis

Gaspera

Armand

Sequeira

et al. 2012

Developmental Dynamics

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Background: Although Xenopus is a key model organism in developmental biology, little is known about the myotome formation in this species. Here, we assessed the expression of myogenic regulatory factors of the Myod family (MRFs) during embryonic development and revealed distinct MRF programs. Results: The expression pattern of each MRF during embryonic development highlights three successive myogenic waves. We showed that a first median and lateral myogenesis initiates before dermomyotome formation: the median cell population expresses Myf5, Myod, and Mrf4, whereas the lateral one expresses Myod, moderate levels of Myogenin and Mrf4. The second wave of myoblasts arising from the dermomyotome is characterized by the full MRF program expression, with high levels of Myogenin. The third wave is revealed by Myf5 expression in the myotome and could contribute to the formation of plurinucleated fibers at larval stages. Furthermore, Myf5-or Myod-expressing anlagen are identified in craniofacial myogenesis. Conclusions: The first median and lateral myogenesis and their associated MRF programs have probably disappeared in mammals. However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5-dependent andindependent lineages. Developmental Dynamics 241:995-1007,

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Distinct and dynamic myogenic populations in the vertebrate embryo

Cited by 188 publications

References 71 publications

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells

Epigenetics and developmental programming of welfare and production traits in farm animals

Myogenic waves and myogenic programs during Xenopus embryonic myogenesis

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