Distinct adverse outcomes and lipid profiles of erythrocytes upon single and combined exposure to cadmium and microplastics

Wang, Lixin; Xu, Min; Chen, Jiamin; Zhang, Xuan; Wang, Quanshu; Wang, Yingxue; Cui, Jiansheng; Zhang, Shuping

doi:10.1016/j.chemosphere.2022.135942

Cited by 11 publications

(3 citation statements)

References 70 publications

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“…the combined effects of Cd + MP were more intense than those induced by MP, but better than those induced by Cd alone. This antagonistic effect has been previously demonstrated in many experimental models and conditions, as MP reduced Cd toxicity in plants (Lian et al, 2020;Wang et al, 2022b;Zhang et al, 2022), fish (Wang S. et al, 2022;Yang et al, 2022), and mice (Wang et al, 2022d). Considering that the two substances were administered separately (oral gavage for MP and drinking water for Cd) and that the rates of adsorption/release of heavy metals by MP depend on pH values (Hildebrandt et al, 2021;Chen et al, 2022), we hypothesized that MP, by exploiting a sort of "positive-Trojan horse effect", may reduce the bioavailability of Cd, explaining the minor consequences observed by concomitant treatment with MP-Cd as compared with Cd alone.…”

Section: Discussionmentioning

confidence: 54%

The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP

Venditti

Hassine

Messaoudi

et al. 2023

Front. Cell Dev. Biol.

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This paper confirms the damaging effects produced by MP and Cd on testicular activity in the rat. Oral treatment with both chemicals resulted in testicular damage, documented by biomolecular and histological alterations, particularly by impaired morphometric parameters, increased apoptosis, reduced testosterone synthesis, and downregulation of the steroidogenic enzyme 3β-HSD. We also demonstrated, for the first time, that both MP and Cd can affect the protein level of PTMA, a small peptide that regulates germ cell proliferation and differentiation. Interestingly, the cytoarchitecture of testicular cells was also altered by the treatments, as evidenced by the impaired expression and localization of DAAM1 and PREP, two proteins involved in actin- and microtubule-associated processes, respectively, during germ cells differentiation into spermatozoa, impairing normal spermatogenesis. Finally, we showed that the effect of simultaneous treatment with MP and Cd were more severe than those produced by MP alone and less harmful than those of Cd alone. This could be due to the different ways of exposure of the two substances to rats (in drinking water for Cd and in oral gavage for MP), since being the first contact in the animals’ gastrointestinal tract, MP can adsorb Cd, reducing its bioavailability through the Trojan-horse effect.

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Section: Discussionmentioning

confidence: 54%

The simultaneous administration of microplastics and cadmium alters rat testicular activity and changes the expression of PTMA, DAAM1 and PREP

Venditti

Hassine

Messaoudi

et al. 2023

Front. Cell Dev. Biol.

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show abstract

“…One study reported that cadmium and PSMPs induced disruption of the membrane components and lipid bilayer of RBCs. 219 Several other investigations demonstrated the toxic impact of MNPs in reducing RBC cell count in various species. 220–222…”

Section: Interaction With the Circulatory Systemmentioning

confidence: 99%

“…These findings indicated RBC membrane function impairment. 215 In a different in vivo experiment employing the C57BL/6 mouse model, animals were given daily 6, 60, or 600 μg per day doses of polyethylene microplastics for 15 days. The outcomes showed that the typical structure of their RBCs was significantly altered by exposure to 600 μg per day of MPs, leading to a variety of aberrant forms.…”

Section: Interaction With the Circulatory Systemmentioning

confidence: 99%