The aviation sector is nowadays looking for a biofuel to partially substitute the fossil fuel used for flights, i.e., jet fuel. Among the proposed processes for the production of the renewable jet fuel, the hydrotreating process has, to date, the best performance. At the final stage of the hydrotreating process, a distillation train is required to obtain hydrocarbon fractions useful as fuels. Conventional or thermally coupled distillation sequences can be used in this step, and it can be expected that thermally coupled sequences require less energy to perform the separation. Nevertheless, in the selection of the best sequence for a given separation, it is important to analyze its control properties. A controllability analysis was performed here for different distillation sequences used to obtain biofuels from a hydrocarbon renewable mixture, in order to detect the best sequence in terms of control properties.