Distant nodal metastasis: is it always an unresectable disease?

Baiocchi, Gian Luca; Celotti, Andrea; Molfino, Sarah; Baggi, Paolo; Tarasconi, Antonio; Baronio, G; Arru, Luca; Gheza, Federico; Tiberio, Guido A M; Portolani, Nazario

doi:10.21037/tgh.2016.12.01

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…The final risk function was H(t) = [h 0 (t)]e (0.922 ×6+1.99 ×8+1.657 ×9) , suggesting that these factors all affect the outcome of NSCLC patients and their risk coefficients were reached at 0.922 and 1.99 respectively. As we all know, once lymph node metastasis and distant metastasis take place, the survival time of patient with malignant tumors will be remarkably shortened, and will also lead to a great adverse to the treatment 27 . Through our results, it is suggested that HSP27 can be used as a new tumor marker to evaluate the prognosis of NSCLC.…”

Section: Discussionmentioning

confidence: 99%

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

Sheng

Liu

et al. 2017

Sci Rep

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Heat shock protein 27 (HSP27) has been found to be related to tumorigenesis. The aim of this study was to investigate the expression pattern and clinical significance of HSP27 in non-small-cell lung cancer (NSCLC). The expression of HSP27 in tissues was examined by immunohistochemistry and serum level of HSP27 mRNA was detected by real-time PCR. The survival analysis was performed by a Kaplan Meier method and the estimation of risk factors was determined by the multiple regression analysis. The expression of HSP27 was increased in lung cancer tissues (p < 0.001) and serum (p < 0.001) of NSCLC patients and higher HSP27 in lung cancer tissues and serum of NSCLC patients was associated with poorly differentiated cancer (p < 0.001; p = 0.035), lymphatic metastasis (p < 0.001; p < 0.001), advanced TNM stage (p < 0.001; p < 0.001). And the levels of HSP27 in tissues and serum of lung cancer patients had a certain positive correlation (p = 0.046). Moreover, increased HSP27 expression correlated with shorter survival of NSCLC patients (p < 0.001). The results suggest that HSP27 may serve as a potential biomarker for diagnosis and prognosis of NSCLC.

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Section: Discussionmentioning

confidence: 99%

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

Sheng

Liu

et al. 2017

Sci Rep

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“…However, acute pancreatitis is a little-known complication of hydatid disease. The primary pancreatic location of hydatid cyst actually represents less than 1% of all cases reported in the literature [ 5 , 6 ]. It is responsible for a few cases of acute pancreatitis by cyst compression or migrated vesicle daughters’ obstruction of the main pancreatic duct [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis as an uncommon complication of hydatid cyst of the liver: A case report and systematic literature review

Mahmoud

Atri

Rebai

et al. 2021

Annals of Medicine and Surgery

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Hydatid disease is a major health problem worldwide. The liver is the most frequent location of hydatid disease. Acute pancreatitis secondary to liver hydatid cyst ruptured in the biliary tract is scarce and fewly described in literature. The management of this pancreatic complication of liver hydatid disease is challenging and includes a combination of surgical and endoscopic approaches. We report herein a rare case of hydatid cyst of the liver with cysto-biliary communication revealed by acute pancreatitis. A systematic literature review of similar cases reported was provided to compare surgical and endoscopic techniques. A thirty-year-old woman was referred to our emergency unit for acute pancreatitis. The CT-scan findings revealed a liver hydatid cyst ruptured in the biliary tract and daughter vesicles within were found, responsible for C-grade acute pancreatitis. We decided then to perform an emergency surgery through a bisoucostal incision. We performed a cholecystectomy and a peroperative cholangiogram that showed the communication between the cyst and left biliary tracts and the presence of daughter vesicle within the common bile duct. We conducted an exploration of the common bile duct with extraction of vesicle daughters. We left behind a T-tube in the common bile duct and we sutured the cysto-biliary fistula. Drainage was left in the remnant cavity after unroofing the cyst. Postoperative course was uneventful. Six months follow-up showed no recurrence. Cysto-biliary communication of liver hydatid disease revealed by acute pancreatitis is uncommon. We chose to perform emergency open surgery. However, through a systematic literature review, we noticed that endoscopic treatment is an efficient therapeutic and diagnostic tool to delay a morbid surgery of the liver and the common bile duct.

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“…GC, being the fifth most commonly occurring cancer, is prevalent in the eastern and central parts of Asia and is the third most common cancer as per the mortality rate [ 3 , 4 ]. Mizoram, Northeastern tribal state of India has the highest incidence rate of gastric cancer in India [ 5 ] and globally occupies the fifth position for GC [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Panel of significant risk factors predicts early stage gastric cancer and indication of poor prognostic association with pathogens and microsatellite stability

et al. 2021

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Background There are very few studies covering the epidemiological risk factors associated with Epstein Barr Virus (EBV) and Microsatellite stability for Gastric Cancer (GC) cases. Early diagnosis of GC through epidemiological risk factors is very necessary for the clinical assessment of GC. The aim of this study was to find out the major risk factors to predict GC in early stage and the impact of pathogen infection and MSI on survival rate of patients. GC samples were screened for Helicobacter pylori, Epstein Barr Virus, and Mismatch repair (MMR) gene status (microsatellite stable or instable). Chi-square and logistic regression analysis of Odd ratio and 95% confidence interval (OR, 95% CI) were performed to find out the association between epidemiological factors and the risk of gastric cancer. The pathogen and MMR gene status were analysed to predict their effect on overall survival and the risk score and hazard ratio was calculated for prognostic assessment. Results Excess body weight, consumption of extra salt, smoked food, alcohol, and smoking were the major risk factors for GC development. This study achieved a high area under the curve (AUC 0.94) for the probable GC patients in early-stage using the five-panel epidemiological risk factors. H. pylori infected cases were significant with smoked food, while EBV was found to be associated with tuibur intake and smoked food. In overall survival analysis EBV infected and microsatellite stable (HR: 1.32 and 1.34 respectively) GC cases were showing poor prognosis. Conclusion This study might provide new opportunities for personalized treatment options using this epidemiological factor risk score and clinicopathological factors assessment for early detection and prognosis in high-risk GC populations.

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Distant nodal metastasis: is it always an unresectable disease?

Cited by 4 publications

References 17 publications

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient’s survival

Acute pancreatitis as an uncommon complication of hydatid cyst of the liver: A case report and systematic literature review

Panel of significant risk factors predicts early stage gastric cancer and indication of poor prognostic association with pathogens and microsatellite stability

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