Distant nodal metastases from intrathoracic esophageal squamous cell carcinoma: Characteristics of long‐term survivors after chemoradiotherapy

Chao, Yin‐Kai; Wu, Yi‐Cheng; Liu, Yun-Hen; Tseng, Chen‐Kan; Chang, Hsien‐Kun; Hsieh, Ming‐Ju; Chu, Yen; Liu, Huiping

doi:10.1002/jso.21588

Cited by 17 publications

(26 citation statements)

References 15 publications

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“…The role of palliative resection and radiation is not clear for metastatic EC. However, recent studies have indicated that palliative resection or radiation might benefit for survival . Some case reports revealed promising results on long term survival after palliative surgery as well as radiation .…”

Section: Discussionmentioning

confidence: 99%

“…The median survival was 10.8 months for these patients, leading to the conclusion that surgery should not be recommended for stage IV EC . However, some articles revealed better prognosis in patients with stage IV EC after multimodality therapy with palliative resection, and/or radiation, and chemotherapy …”

Section: Introductionmentioning

confidence: 99%

“…5 However, some articles revealed better prognosis in patients with stage IV EC after multimodality therapy with palliative resection, and/or radiation, and chemotherapy. [6][7][8] The Surveillance, Epidemiology, and End Results (SEER) database provides real-world information on cancer statistics among American population. We aim to explore the value of palliative resection or radiation of tumor in metastatic EC based on the data from SEER database.…”

Section: Introductionmentioning

confidence: 99%

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Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

Donghui²,

Zhang

et al. 2019

Cancer Medicine

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PurposeWe aimed to explore the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer (EC) patients.MethodsSurveillance, Epidemiology, and End Results database was used for identifying metastatic EC patients. The patients were divided into resection and nonresection groups. And patients without resection were divided into radiation and nonradiation groups. Propensity score matching (PSM) analyses were adopted to reduce the baseline differences between the groups. Cancer specific survivals (CSSs) and overall survivals (OSs) were compared by Kaplan‐Meier (K‐M) curves. Multivariable analyses by COX proportion hazards model were performed to identify risk factors for CSS and OS. Predictive nomograms were conducted according to both postoperative factors and preoperative factors.ResultsA total of 7982 metastatic EC patients were selected for our analyses. After PSM, 978 patients were included in the survival analyses comparing palliative resection and nonresection. The CSS and OS for patients underwent palliative resection were significantly longer than those without resection (median CSS: 21 months vs 7 months, P < .001; median OS: 20 months vs 7 months, P < .001). In the overall population without resection, 654 patients were matched for radiation and nonradiation groups. And K‐M curves showed that patients with radiation had longer CSS and OS than those without radiation (median CSS: 11 months vs 6 months, P < .001; median OS: 10 months vs 6 months, P < .001). Nomograms were generated for prediction of 1‐, 2‐, and 3‐year CSS and OS. All C‐indexes implied moderate discrimination and accuracy. And all nomograms had good calibration.ConclusionPalliative resection or radiation of primary tumor could prolong CSS and OS of metastatic EC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

Donghui²,

Zhang

et al. 2019

Cancer Medicine

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“…Whether surgery has a role in metastatic esophageal cancer has not been defined, although 2 small studies 13,25 had also suggested that long-term survival can be achieved after resection of metastatic esophageal cancer. Our study substantiates these other reports and also validates R0 resection and pathologic CR as favorable prognostic factors.…”

Section: Discussionmentioning

confidence: 99%

Factors Predictive of Improved Outcomes With Multimodality Local Therapy After Palliative Chemotherapy for Stage IV Esophageal Cancer

Wang

Suri

Allen

et al. 2016

American Journal of Clinical Oncology

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“…Wang et al included 96 patients with stage IV EC who were received palliative chemotherapy and concurrent chemoradiotherapy (CRT), of which 14 patients underwent surgery after neoadjuvant therapy and surgery had significantly better survival than those who did not11. Two related studies also showed that long-term survival could be achieved after resection of the primary tumor and metastases of stage IV EC1213. In our study, 1,273 patients received surgery with or without RT, and surgery combined with RT could significantly improve survival.…”

Section: Discussionmentioning

confidence: 99%

Surgery Combined with Radiotherapy Improved Survival in Metastatic Esophageal Cancer in a Surveillance Epidemiology and End Results Population-based Study

Xie

Zhang

et al. 2016

Sci Rep

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This retrospective study used a population-based national registry to determine the impact of local treatment modalities on survival in patients with metastatic esophageal cancer (EC). The Surveillance Epidemiology and End Results (SEER) database was used to identify patients with metastatic EC from 1988 to 2012. A total of 9,125 patients were identified. There were 426 patients underwent primary surgery, 4,786 patients were administered radiotherapy (RT) alone, 847 patients underwent surgery plus RT, and 3,066 patients without any local treatment. Multivariate analysis results indicated that year of diagnosis, age, race, histologic subtype, grade, and local treatment modalities were independent prognostic factors for overall survival (OS). The 5-year OS were 8.4%, 4.5%, 17.5%, and 3.4% in primary surgery, RT only, surgery plus RT, and no local treatment, respectively (P < 0.001). Subgroup analyses showed that the impact of RT was mainly reflected by preoperative radiotherapy, as patients received preoperative radiotherapy had significantly better OS than patients who underwent primary surgery alone and postoperative RT, the 5-year OS rates were 24.7%, 6.5%, and 7.8%, respectively, respectively (P < 0.001). Surgery plus RT, especially preoperative RT, may improve long-term survival of patients with metastatic EC.

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Distant nodal metastases from intrathoracic esophageal squamous cell carcinoma: Characteristics of long‐term survivors after chemoradiotherapy

Abstract: Pretherapy M1a disease had a significantly better survival than nodal M1b disease after CRT in SCC. Aggressive surgical treatment after CRT is reserved for cases when complete resection is anticipated.

Cited by 17 publications

References 15 publications

Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

Palliative resection or radiation of primary tumor prolonged survival for metastatic esophageal cancer

Factors Predictive of Improved Outcomes With Multimodality Local Therapy After Palliative Chemotherapy for Stage IV Esophageal Cancer

Surgery Combined with Radiotherapy Improved Survival in Metastatic Esophageal Cancer in a Surveillance Epidemiology and End Results Population-based Study

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