Distant melanoma causing small bowel obstruction

Hintze, Justin M.; O’Connor, Donal B; Molony, Peter; Neary, Paul

doi:10.1093/jscr/rjx020

Cited by 4 publications

(7 citation statements)

References 11 publications

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“…A systematic review and meta-analysis by Hong et al showed that a metastatic carcinoma acted as a culprit in the majority of intussusception cases [9]. Known for its high metastatic potential, malignant melanoma has the tendency to metastasize to the gastrointestinal tract as the third most common site, with the small intestine commonly affected which is largely attributed to its rich blood supply [10][11][12]. Despite this, metastatic melanoma causing small bowel obstruction is relatively rare [3].…”

Section: Discussionmentioning

confidence: 99%

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

Ahdi¹,

Kruchko²,

Asado³

et al. 2023

Cureus

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Intussusception in adults is a rare finding with a majority of cases occurring in the pediatric population. It occurs infrequently and its presentation, etiology, and treatment differ from childhood intussusception. When discovered in adults, it raises suspicion for a neoplastic process serving as the pathological lead point. Cross-sectional imaging is the primary study of choice for diagnosis, but at times, a more invasive approach involving an exploratory laparotomy is required posing an increased risk for morbidity and mortality. Here we present a 64-year-old male who was found to have jejunal-jejunal intussusception that was surgically removed with pathology revealing metastatic melanoma as the lead point. This case highlights a unique presentation of a melanoma that was previously eradicated with immunotherapy and now had metastasized to the intestine many years later.

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Section: Discussionmentioning

confidence: 99%

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

Ahdi¹,

Kruchko²,

Asado³

et al. 2023

Cureus

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“…Most cases are due to metastasis from a primary cutaneous lesion, and few reports of primary melanoma of the small bowel exist in the literature. An autopsy study found that 60% of all patients with melanoma had intestinal metastasis, with the small intestine being involved in 50% of cases, the colon in 31%, and the ano-rectum in 25% [6]. Hintze et al concluded that melanoma is the “most common extra-intestinal malignancy to metastasize to the [GI tract], and metastases can occur many years later” [6].…”

Section: Discussionmentioning

confidence: 99%

“…An autopsy study found that 60% of all patients with melanoma had intestinal metastasis, with the small intestine being involved in 50% of cases, the colon in 31%, and the ano-rectum in 25% [6]. Hintze et al concluded that melanoma is the “most common extra-intestinal malignancy to metastasize to the [GI tract], and metastases can occur many years later” [6]. The higher incidence of metastasis to the small bowel may be due to its rich blood supply [7].…”

Section: Discussionmentioning

confidence: 99%

Small Bowel Intussusception Caused by Metastatic Melanoma: A Case Report

Ahmed¹,

Abbas²,

Abdulsalam³

et al. 2019

Cureus

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Intussusception, as a rare cause of small bowel obstruction, can be secondary to benign or malignant pathology. Malignant lesions causing intussusception can be primary or metastatic lesions. Metastasis can occur many years later. We present a case of metastatic melanoma in a 69-year-old man as the underlying etiology of his intussusception. The patient had laparoscopic Roux-en-Y gastric bypass four years prior to his presentation and did recall excision of a skin melanoma at age 64. Laparoscopic or open surgical resection is the best therapeutic option in cases such as this.

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“…Metastases from an unknown primary to the small bowel can well be a cause of obstruction and manifest in an emergency setting [ 98 , 99 ]: a description of bifocal metastases of melanoma treated through partial resection of the jejunum and distal ileum with termino-terminal anastomosis have been described.…”

Section: Main Findings Of the Literature (Review) Questmentioning

confidence: 99%

Intra-Abdominal Malignant Melanoma: Challenging Aspects of Epidemiology, Clinical and Paraclinical Diagnosis and Optimal Treatment—A Literature Review

et al. 2022

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According to European consensus-based interdisciplinary guidelines for melanoma, cutaneous melanoma (CM) is the most deadly form of dermatological malignancy, accounting for 90% of the deaths of skin cancer patients. In addition to cutaneous melanoma, mucosal melanoma occurs in four major anatomical sites, including the upper respiratory tract, the conjunctiva, the anorectal region, and the urogenital area. As this cancer type metastasizes, a classification used in the current medical literature is the distinction between secondary lesions and primary malignant melanoma of the abdominal cavity. Given that malignant melanoma is the most common cancer that spreads to the gastrointestinal tract, different imaging modalities compete to diagnose the phenomenon correctly and to measure its extension. Treatment is primarily surgery-based, supported by immunotherapy, and prolongs survival, even when performed at stage IV illness. In the end, special forms of malignant melanoma are discussed, such as melanoma of the genito-urinary tract and amelanotic/achromic melanoma. The importance of this present literature review relies on yielding and grouping consistent and relevant, updated information on the many aspects and challenges that a clinician might encounter during the diagnosis and treatment of a patient with intra-abdominal melanoma.

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Distant melanoma causing small bowel obstruction

Cited by 4 publications

References 11 publications

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

A Case of Jejuno-Jejunal Intussusception Caused by Underlying Metastatic Melanoma

Small Bowel Intussusception Caused by Metastatic Melanoma: A Case Report

Intra-Abdominal Malignant Melanoma: Challenging Aspects of Epidemiology, Clinical and Paraclinical Diagnosis and Optimal Treatment—A Literature Review

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