Distance saturation product predicts health–related quality of life among sarcoidosis patients

Bourbonnais, Julie M.; Malaisamy, Subramanian; Dalal, Bhavinkumar; Samarakoon, Priyan C; Parikh, Swapna; Samavati, Lobelia

doi:10.1186/1477-7525-10-67

Cited by 23 publications

(31 citation statements)

References 40 publications

(53 reference statements)

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“…Lettieri et al found that DSP provides a novel measurement with slightly better accuracy than other parameters to predict survival of patients with idiopathic pulmonary fibrosis (13). In patients with sarcoidosis, Bourbonnais et al reported that DSP is an easily calculated clinical parameter to predict healthrelated quality of life over time and for intervention (26). The results of the present study showed that both walking distance and the lowest oxygen saturation during 6MWT were independently predictive of outcome in non-CF bronchiectasis.…”

Section: Correlations Between 6mwt-derived Variables and 6-year Survivalsupporting

confidence: 63%

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Distance-saturation product of the 6-minute walk test predicts mortality of patients with non-cystic fibrosis bronchiectasis

et al. 2017

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Background: Previous surveillance methods to monitor the prognoses of patients with bronchiectasis are too complex for use in daily practice. The 6-minute walk test (6MWT) is a simple exercise test to predict the prognosis of chronic obstructive airway disease and numerous chronic lung diseases, including idiopathic pulmonary fibrosis. No studies have investigated exercise-induced oxygen desaturation (EID) and distancesaturation product (DSP) of 6MWT to predict the prognoses of patients with bronchiectasis. Methods: This was a prospective study to identify correlations between variables of 6MWT and mortality in patients with bronchiectasis over a 6-year period. The study cohort included 69 patients with stable noncystic fibrosis (non-CF) bronchiectasis who were regularly evaluated for functional status via 6-minute walk distance (6MWD), spirometry, BODE index, EID, and DSP.Results: Of the 69 patients, 9 (13%) died and 60 (87%) survived during the 6-year follow-up period. Multivariate analysis showed that DSP (OR =0.983; P=0.001) was the best parameter of 6MWT to predict mortality. Patients with a lower DSP of <280 m% were at a 66.5-fold greater risk (OR =66.5; 95% CI: 9.4-469.2) of 6-year mortality compared with those with DSP >280 m% (P<0.001).Conclusions: DSP is a simple parameter to predict 6-year mortality in patients with non-CF bronchiectasis.

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Section: Correlations Between 6mwt-derived Variables and 6-year Survivalsupporting

confidence: 63%

“…The application of DSP in patients with a variety of chronic lung diseases has been reported (13,20,26). Lettieri et al found that DSP provides a novel measurement with slightly better accuracy than other parameters to predict survival of patients with idiopathic pulmonary fibrosis (13).…”

Section: Correlations Between 6mwt-derived Variables and 6-year Survivalmentioning

confidence: 99%

Distance-saturation product of the 6-minute walk test predicts mortality of patients with non-cystic fibrosis bronchiectasis

et al. 2017

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“…In contrast, in sarcoidosis, the strongest predictor of modified Borg dyspnoea score during 6MWT was nonvolitional measures of respiratory muscle strength [150]. Modified Borg dyspnoea score after the 6MWT was also an independent predictor of HRQoL in people with sarcoidosis [151].…”

Section: Dyspnoeamentioning

confidence: 94%

“…23 studies related to subjective fatigue were retrieved in full text and 12 were included in this section, all related to COPD [148][149][150][151][152][153][154][155][156][157][158][159].…”

Section: Dyspnoeamentioning

confidence: 99%

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

Singh¹,

Puhan²,

et al. 2014

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This systematic review examined the measurement properties of the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease.Studies that report the evaluation or use of the 6MWT, ISWT or ESWT were included. We searched electronic databases for studies published between January 2000 and September 2013.The 6-min walking distance (6MWD) is a reliable measure (intra-class correlation coefficients ranged from 0.82 to 0.99 in seven studies). There is a learning effect, with greater distance walked on the second test (pooled mean improvement of 26 m in 13 studies). Reliability was similar for ISWT and ESWT, with a learning effect also evident for ISWT (pooled mean improvement of 20 m in six studies). The 6MWD correlates more strongly with peak work capacity (r50.59-0.93) and physical activity (r50.40-0.85) than with respiratory function (r50.10-0.59). Methodological factors affecting 6MWD include track length, encouragement, supplemental oxygen and walking aids. Supplemental oxygen also affects ISWT and ESWT performance. Responsiveness was moderate to high for all tests, with greater responsiveness to interventions that included exercise training.The findings of this review demonstrate that the 6MWT, ISWT and ESWT are robust tests of functional exercise capacity in adults with chronic respiratory disease. OverviewThe aim of this systematic review was to examine the measurement properties for the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease. A companion paper describes the standard operating procedures for the tests [1]. The key findings of this systematic review are as follows.1) The 6-min walking distance (6MWD) is a valid and reliable measure of exercise capacity for people with chronic lung disease. The 6MWD correlates more strongly with measures of peak work capacity and physical activity than with respiratory function or quality of life, which supports its conceptualisation as a test of functional exercise performance.2) The ISWT offers a different protocol to the 6MWT as it is incremental and externally paced. The ISWT is a valid and reliable measure of cardiopulmonary exercise capacity in chronic obstructive pulmonary disease (COPD), where there is a strong relationship between ISWT distance and peak oxygen uptake (V9O 2 peak) or work rate on a cardiopulmonary exercise test (CPET).3) A learning effect is observed for the 6MWT and the ISWT. The second test usually is the better compared with the first, but this is inconsistent.4) The ESWT is a test of endurance capacity. It is externally paced and is performed along the same course as the ISWT. Two tests do not appear to be necessary if the second test is conducted on the same day.5) Reference equations have been proposed for the 6MWD and the ISWT. Age, height and weight are included in most equations. The influence of race and ethnicity is unclear.6) The safety profile of ...

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“…These include the distance-saturation product [42][43][44][45], the desaturation area [46] and the desaturation-distance ratio [47]. As only a small number of studies are available, the utility of these measures has not been confirmed and they are not routinely collected during the 6MWT.…”

Section: Oxyhaemoglobin Saturationmentioning

confidence: 99%

An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease

Holland¹,

Spruit²,

Troosters³

et al. 2014

Eur Respir J

1,759

1,537

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Field walking tests are commonly employed to evaluate exercise capacity, assess prognosis and evaluate treatment response in chronic respiratory diseases. In recent years, there has been a wealth of new literature pertinent to the conduct of the 6-min walk test (6MWT), and a growing evidence base describing the incremental and endurance shuttle walk tests (ISWT and ESWT, respectively). The aim of this document is to describe the standard operating procedures for the 6MWT, ISWT and ESWT, which can be consistently employed by clinicians and researchers.The Technical Standard was developed by a multidisciplinary and international group of clinicians and researchers with expertise in the application of field walking tests. The procedures are underpinned by a concurrent systematic review of literature relevant to measurement properties and test conduct in adults with chronic respiratory disease.Current data confirm that the 6MWT, ISWT and ESWT are valid, reliable and responsive to change with some interventions. However, results are sensitive to small changes in methodology. It is important that two tests are conducted for the 6MWT and ISWT.This Technical Standard for field walking tests reflects current evidence regarding procedures that should be used to achieve robust results. OverviewThe aim of this Technical Standard is to document the standard operating procedures for the 6-min walk test (6MWT), incremental shuttle walk test (ISWT) and endurance shuttle walk test (ESWT) in adults with chronic respiratory disease. The testing procedures were developed by a multinational and multidisciplinary group of experts in field exercise testing, informed by a systematic review of the measurement properties and interpretation of the 6MWT, ISWT and ESWT in adults with chronic respiratory disease [1].The key findings of the Technical Standard are as follows.1) The 6-min walking distance (6MWD), ISWT and ESWT demonstrate good construct validity. Strong relationships with measures of exercise performance and physical activity support their conceptualisation as tests of functional exercise performance.2) A lower 6MWD is strongly associated with increased risk of hospitalisation and mortality in people with chronic respiratory disease, with a small number of studies suggesting a similar relationship for the ISWT.3) The 6MWD, ISWT and ESWT exhibit good test-retest reliability; however, there is strong evidence of a learning effect for the 6MWT and ISWT. Two tests should be performed when the 6MWT or ISWT are used to measure change over time.4) The 6MWD, ISWT and ESWT are responsive to treatment effects in people with chronic respiratory disease; however, most studies have evaluated responsiveness to rehabilitation and fewer data are available to confirm responsiveness to other interventions.5) The 6MWD and ISWT elicit a peak oxygen uptake (V9O 2 peak) that is similar to that during a cardiopulmonary exercise test (CPET). As a result, the contraindications and precautions for field testing should be consistent with those ...

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Distance saturation product predicts health–related quality of life among sarcoidosis patients

Cited by 23 publications

References 40 publications

Distance-saturation product of the 6-minute walk test predicts mortality of patients with non-cystic fibrosis bronchiectasis

Distance-saturation product of the 6-minute walk test predicts mortality of patients with non-cystic fibrosis bronchiectasis

An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease

An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease

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