Distance-based detection in analytical flow devices: From gas detection tubes to microfluidic chips and microfluidic paper-based analytical devices

Nuchtavorn, Nantana; Rypar, Tomas; Nedjl, Lukas; Vaculovičová, Markéta; Macka, Mirek

doi:10.1016/j.trac.2022.116581

Cited by 29 publications

(13 citation statements)

References 87 publications

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“…Because their general processes rely on the length of color changes in the detection area, corresponding to the analyte level, the analyte solution can flow along the detection channel and then react with a deposited specific reagent that was predeposited. − The results show the changes in the color length on the dPADs, illustrating the need for an equipment-free detection system for onsite analysis. With these properties, it can be noticed that there were numerous developments of dPADs for various detections with different reactions including enzymatic, metal nanoparticle aggregation, and complexation reactions. − Therefore, dPAD sensors are more advantageous for point of care (POC) testing in resource-poor settings because they do not require external equipment to evaluate the data for quantification. − …”

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confidence: 99%

A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application

et al. 2022

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This work introduces the concept of a counting-based measurement on paper analytical devices (cPADs) to improve the utilization of numerous reactions. The design of cPADs consists of two layers of paper substrates; the first layer contains a central sample zone combined with a radial surrounded by 12 detection zones that are predeposited with the various reagents, and the second layer acts as a connection channel between the sample zone and each detection zone. The solution can vertically flow from the first to the second layer and then move through the area to each subsequent detection zone. The analyte level can be evaluated by counting the number of detection zones that change color from a blank signal. Furthermore, our cPADs exhibit a capability of implementation for a broad series of reactions. Compared to the dPAD technique, some reactions that are possibly difficult to apply in such devices can be wholly enabled in our devices. The final color reaction on cPADs can apparently occur due to its identity. We applied this technique to the monitoring of carbaryl (CBR) and copper ions (Cu2+) using different reactions, including azo-coupling and complexation, respectively. Accordingly, this indicates an excellent result validated using the more traditional methods. Our cPADs can be applied for rapid screening of both CBR and Cu2+ in water samples with outstanding accuracy and precision using a naked-eye measurement by a relatively unskilled person. We offer a simple platform on PADs for rapid screening, combining high cost-effectiveness within a miniaturized platform designed for use with onsite applications, which is thus suitable for several different reactions.

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confidence: 99%

A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application

et al. 2022

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“…In general, the color formation progresses to a certain distance in the channel, allowing quantitative assessment of concentration. 24,27,30…”

Section: Introductionmentioning

confidence: 99%

“…24 Paper-based microuidic analytical devices (mPADs) are ideal for such analyses, especially for point-of-care applications. [25][26][27] Among the colorimetric methods, distance-based detection has gained attention due to its practicality in instrument-free semi-quantitative analysis. 27 Distance-based assays require only two steps: sample addition and analysis.…”

Section: Introductionmentioning

confidence: 99%

Distance-based detection of paracetamol in microfluidic paper-based analytical devices for forensic application

Moreira,

Pinheiro,

Sousa

et al. 2024

Anal. Methods

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“…Similarly, cellulosic paper was used as a porous material platform for sensing devices [16,17], enzymatic reactors [18,19], and MIPs extraction sorbents [20,21]. Paper is a ubiquitous, inexpensive, and biodegradable material that is compatible with a wide range of chemicals.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia

Nuchtavorn

Leanpolchareanchai

Visansirikul

et al. 2023

IJMS

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Charantin is a mixture of β-sitosterol and stigmastadienol glucosides, which effectively lowers high blood glucose. Novel molecularly imprinted polymers coated magnetic nanoparticles (Fe3O4@MIPs) and filter paper (paper@MIPs) were synthesized by sol-gel polymerization to selectively extract charantin. β-sitosterol glucoside was selected as a template for imprinting a specific recognition owing to its larger molecular surface area than that of 5,25-stigmastadienol glucoside. Factorial designs were used to examine the effects of the types of porogenic solvents and cross-linkers on the extraction efficiency and imprinting factor before investigating other factors (for example, amounts of template and coated MIPs, and types of substrates for MIP immobilization). Compared to traditional liquid–liquid extraction, the optimal Fe3O4@MIP-based dispersive micro-solid phase extraction and paper@MIP extraction provided excellent extraction efficiency (87.5 ± 2.1% and 85.0 ± 2.9%, respectively) and selectivity. Charantin was well separated, and a new unidentified sterol glucoside was observed using the developed high-performance liquid chromatography with diode-array detection (Rs ≥ 2.0, n > 16,400). The developed methods were successfully utilized to extract and quantify charantin from M. charantia fruit powder and herbal products. Moreover, these methods are rapid (<10 min), inexpensive, simple, reproducible, and environmentally friendly.

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Distance-based detection in analytical flow devices: From gas detection tubes to microfluidic chips and microfluidic paper-based analytical devices

Cited by 29 publications

References 87 publications

A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application

A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application

Distance-based detection of paracetamol in microfluidic paper-based analytical devices for forensic application

Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia

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