Distal Sensory Peripheral Neuropathy: An Undervalued Determinant of Wellbeing

Anastasi, Joyce K.; Devine, Daniel K; Capili, Bernadette

doi:10.31488/heph.169

Cited by 1 publication

(1 citation statement)

References 25 publications

(60 reference statements)

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“…The Average Severity Score (SPNS Average) and Clinical Severity Grade (SPNS Grade) were computed for the analysis. The SPNS Average is the mean daily symptom severity score ranging from mild (1) to most severe (10), and the SPNS Grade is the highest symptom severity score of any symptom (aching/burning, pins and needles, or numbness).…”

Section: Group 4: Waitlist (Control)mentioning

confidence: 99%

Symptom Management for Distal Sensory Peripheral Neuropathy in T2DM: A Preliminary RCT using Moxibustion

K Anastasi,

Capili,

Hackett

et al. 2023

J Clin Biomed Res

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Distal sensory peripheral neuropathy (DSP) is a chronic, painful condition in the lower limbs of many individuals with Type 2 Diabetes (T2DM). DSP is the most prevalent complication of T2DM. Moxibustion, a traditional Chinese medicine therapy, offers a non-invasive and promising treatment for DSP pain. This study examined Traditional and Smokeless Moxibustion in a prospective, randomized, placebo-and waitlist-controlled, subject-and evaluator-blinded, parallel-group clinical trial. Participants received twice weekly moxibustion treatments for three weeks and were followed for two months. Participants in this preliminary study completed symptom diaries, Gracely Pain Scale (GPS), Subjective Peripheral Neuropathy Scale (SPNS), and Clinical Global Impression Scale (CGIS) patient-rated outcomes. In both Traditional and Smokeless Moxibustion groups, not control groups, GPS symptom severity decreased from baseline to end of treatment, and the benefit was sustained for two months post-treatment, p< 0.001. In treated groups, all three SPNS characteristics (pain, pins/needles, numbness) decreased by >3 severity levels at the end of treatment and were unchanged from baseline in control groups, p <0.001. Traditional and Smokeless Moxibustion show promise as a non-invasive and non-pharmacologic therapy in DSP symptoms associated with T2DM. Standards for Reporting Interventions in Controlled Trials of Acupuncture-Moxibustion (STRICTA-M) guided the development and design of this study.

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Section: Group 4: Waitlist (Control)mentioning

confidence: 99%