Distal sensory disorders in Dupuytren's disease

Gerosa, Thibault; Pierrart, J.; Serane-Fresnel, Julien; Amsallem, Lior; Masméjean, E.

doi:10.1016/j.otsr.2018.06.004

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Conversely, there is abundant information about changes in Pacinian corpuscles in palmar fibromatosis [ 7 , 8 , 9 , 10 , 11 , 12 , 27 ], and therefore the discussion of the present results must necessarily be in relation to this pathology. Moreover, a relationship between superficial fibromatosis and the peripheral nervous system has been described recently, noting diminished mean sensitivity in palmar fibromatosis patients [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Pacinian Corpuscles as a Diagnostic Clue of Ledderhose Disease—A Case Report and Mapping of Pacinian Corpuscles of the Sole

et al. 2022

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Background: Plantar fibromatosis, known as Ledderhose disease, is a neoplastic disease characterized by a locally-aggressive bland fibroblastic proliferation. Although Pacinian corpuscles alterations are commonly described in palmar fibromatosis, there are still no references about Pacinian corpuscles alterations in the rarer plantar version. Methods: We present a case report where a wide cutaneous resection, including the plantar fascia was performed, allowing a detailed study of Pacinian corpuscles. Pacinian corpuscles were analyzed using immunohistochemistry for neurofilament proteins, S100 protein, CD34, vimentin, glucose transporter 1, epithelial membrane antigen, neural-cell adhesion molecule, actin, desmin, type IV collagen, and high-affinity neurotrophin Trk-receptors. Moreover, the density and the size of the corpuscles were determined. Results: A clear increase in the number (hyperplasia) of Pacinian corpuscles was evidenced in the Ledderhose disease plantar fascia in comparison with similarly aged normal subjects. Pacinian hypertrophy was not demonstrated, but a significant decrease in the number of corpuscular lamellae was noted, with a subsequent increase in the interlamellar spaces. Pacinian corpuscles from the pathological plantar fascia showed an abnormal structure and immunohistochemical profile, generally without identifiable axons, and also absence of an inner core or an intermediate layer. Moreover, other molecules related with trophic maintenance of corpuscles were also absent. Finally, a vascular proliferation was commonly noted in some corpuscles, which involved all corpuscular constituents. Conclusion: The observed Pacinian corpuscles hyperplasia could be considered a diagnostic clue of plantar fibromatosis.

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Section: Discussionmentioning

confidence: 99%

Pacinian Corpuscles as a Diagnostic Clue of Ledderhose Disease—A Case Report and Mapping of Pacinian Corpuscles of the Sole

et al. 2022

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“…Although most patients experience discomfort, pain is only an occasional side effect in the initial stages (von Campe et al, 2012). However, pain is probably the extreme pole of a disease with an important peripheral nervous system involvement, as reduced sensitivity, likely due to peripheral and entrapment neuropathy, has been found in PF patients (Gerosa et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

et al. 2021

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The human palmar aponeurosis is involved in hand proprioception, and it contains different sensory corpuscle morphotypes that serve this role. In palmar fibromatosis (classically referred to as Dupuytren's disease), the palmar aponeurosis undergoes fibrous structural changes that, presumably, also affect the nervous system, causing altered perception. We analysed the various sensory nerve formation morphotypes in the palmar aponeuroses of healthy subjects and patients with palmar fibromatosis. To do this, we used immunohistochemistry for corpuscular constituents and the putative mechanoproteins PIEZO2 and acid‐sensing ion channel 2. Free nerve endings and Golgi‐Mazzoni, Ruffini, paciniform and Pacinian corpuscles were identified in both the healthy and the pathological conditions. The densities of the free nerve endings and Golgi‐Mazzoni corpuscles were slightly increased in the pathological tissues. Furthermore, the Pacinian corpuscles were enlarged and displayed an altered shape. Finally, there was also morphological and immunohistochemical evidence of occasional denervation of the Pacinian corpuscles, although no increase in their number was observed. Both PIEZO2 and acid‐sensing ion channel 2 were absent from the altered corpuscles. These results indicate that the human palmar aponeurosis is richly innervated, and the free nerve endings and sensory corpuscles within the palmar aponeurosis undergo quantitative and qualitative changes in patients with palmar fibromatosis, which may explain the sensory alterations occasionally reported for this pathology.

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Patients With Dupuytren Disease Use Excessive Grip Force When Lifting and Holding Small Objects, Independent of the Degree of Contracture

Haas-Lützenberger¹,

Pippich²,

Allgöwer³

et al. 2023

Archives of Physical Medicine and Rehabilitation

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Distal sensory disorders in Dupuytren's disease

Abstract: IV, case-control study, diagnostic study.

Cited by 3 publications

References 12 publications

Pacinian Corpuscles as a Diagnostic Clue of Ledderhose Disease—A Case Report and Mapping of Pacinian Corpuscles of the Sole

Pacinian Corpuscles as a Diagnostic Clue of Ledderhose Disease—A Case Report and Mapping of Pacinian Corpuscles of the Sole

Sensory innervation of the human palmar aponeurosis in healthy individuals and patients with palmar fibromatosis

Patients With Dupuytren Disease Use Excessive Grip Force When Lifting and Holding Small Objects, Independent of the Degree of Contracture

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