Distal Peripheral Microembolism

Chauvapun, Joe P.; Dryjski, Maciej L.

doi:10.1258/rsmvasc.13.1.50

Cited by 7 publications

(2 citation statements)

References 56 publications

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“…However, in the present case, treatment of microembolic showers is less effective and is based on the use of heparin sodium, intensive support and treatment of end-organ dysfunction. The use of high-dose heparin is indicated due to its potential to reduce tissue damage [10], as it may improve collateral flow and decrease permeability changes [11]- [13]. Moreover, heparin may suppress tissue plasminogen activator and matrix metalloproteinase production [14].…”

Section: Discussionmentioning

confidence: 99%

Massive Thromboembolism from an Abdominal Aortic Aneurysm after Successful Thrombolysis for an Acute Myocardial Infarction

Bernardi¹,

Rezende²,

Garzillo³

et al. 2015

CRCM

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Thrombolytic therapy is indicated to the treatment of patients with ST-elevation myocardial infarction or pulmonary embolism. Its indication should especially consider the risk of bleeding, but other complications might pose harm to patients. Although rarely reported, fibrinolysis can trigger thromboembolic phenomena from emboligenic sources such as aortic aneurysms. Clinicians should be aware of this life-threatening complication. In this case report, we present one patient admitted due to a ST-segment elevation acute myocardial infarction successfully treated with fibrinolytic treatment, but who evolved with a massive microembolism from an abdominal aortic aneurysm. Despite intensive medical care, the patient evolved with multiorganic failure due to distal microembolism to the guts and lower limbs, severe rhabdomyolysis and ultimately to death. In this challenging case, clinical, anatomical and histopathologic features are presented and discussed.

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Section: Discussionmentioning

confidence: 99%

Massive Thromboembolism from an Abdominal Aortic Aneurysm after Successful Thrombolysis for an Acute Myocardial Infarction

Bernardi¹,

Rezende²,

Garzillo³

et al. 2015

CRCM

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“…Acute arterial occlusion due to an embolus or a thrombus causes hypoxia (a decrease in oxygen supply) or anoxia (a complete deprivation of oxygen supply) not only in the vascular bed, but also in its distal tissue, usually resulting in critical injury or death [1,2,3,4,5,6]. In general, crucial features of the cellular response to hypoxia are considered to release vasoactive substances, to modulate ion channels, to produce the most common free radical superoxide, and to regulate transcriptional factors [7].…”

Section: Introductionmentioning

confidence: 99%

Influence of Hypoxia on Endothelium-Derived NO-Mediated Relaxation in Rat Carotid, Mesenteric and Iliac Arteries

Tawa

Shimosato²,

Geddawy³

et al. 2013

Pharmacology

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Individual vascular beds exhibit differences in vascular reactivity. The present study examined the influence of hypoxia on endothelium-dependent, especially nitric oxide (NO)-mediated, relaxation in the isolated rat common carotid, superior mesenteric and external iliac arteries. Hypoxia for 1 and 3 h had no effects on the relaxations caused by acetylcholine (ACh) and sodium nitroprusside (SNP) in common carotid and external iliac arteries. In addition, NO synthase inhibitor N^G-nitro-L-arginine (L-NA, 10 μmol/l)-resistant, endothelium-dependent relaxations by ACh were also unaffected by hypoxia in these arteries. On the other hand, ACh-induced relaxation in superior mesenteric arteries was significantly impaired by exposure to hypoxia, while this condition did not affect the relaxation induced by SNP or ACh in the presence of L-NA. This impairment was partially prevented by treatment with tempol (3 mmol/l), a superoxide scavenger. These findings demonstrate a marked heterogeneity in response to hypoxia in rat arteries. Briefly, acute hypoxia induces impairment of endothelium-derived NO-mediated relaxation through the decrease in its bioavailability in the superior mesenteric, but not in common carotid or external iliac, arteries. Furthermore, superoxide seems to be one causal factor responsible for the undesirable effect of hypoxia.

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New Microembolus Size Estimator for Peripheral Blood Vessels

Żmigrodzki

Kałużyński

2012

Ultrasound in Medicine & Biology

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Distal Peripheral Microembolism

Cited by 7 publications

References 56 publications

Massive Thromboembolism from an Abdominal Aortic Aneurysm after Successful Thrombolysis for an Acute Myocardial Infarction

Massive Thromboembolism from an Abdominal Aortic Aneurysm after Successful Thrombolysis for an Acute Myocardial Infarction

Influence of Hypoxia on Endothelium-Derived NO-Mediated Relaxation in Rat Carotid, Mesenteric and Iliac Arteries

New Microembolus Size Estimator for Peripheral Blood Vessels

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