Distal nephron neoplasms

Fleming, Stewart

doi:10.1053/j.semdp.2015.02.004

Cited by 25 publications

(21 citation statements)

References 68 publications

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“…The tumors are generally well circumscribed and partially encapsulated, with a wide size range from less than 1-cm diameter to greater than 18-cm. The cut surface is commonly bulging, shiny and mucoid, with a uniform homogenous tan, gray or pale yellow color and a solid consistency [ 7 , 9 , 8 , 12 ] (Fig. 1 ).…”

Section: Reviewmentioning

confidence: 99%

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Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects

Zhao

Teng

2015

Diagn Pathol

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Mucinous tubular and spindle cell renal cell carcinoma is a rare, recently described variant of renal cell carcinoma characterized by an admixture of cuboidal cells in tubules and sheets of spindle cells, and variable amounts of mucinous stroma. It has been recognized as a distinct entity in the 2004 World Health Organization tumor classification. Since then, several dozen of these tumor have been reported with additional complementary morphologic characteristics, immunohistochemical profile, and molecular genetic features that have further clarified its clinicopathologic aspects. Although originally considered as a low grade renal cell carcinoma on the basis of its bland appearing nuclear features and indolent clinical course, mucinous tubular and spindle cell renal cell carcinoma has currently been proven to be a tumor that has a histological spectrum ranging from low to high grade that includes sarcomatoid differentiation. In this review, we present a detailed summary of the current knowledge regarding the clinicopathologic, immunohistochemical, molecular genetic, and prognostic characteristics, as well as differential diagnoses of mucinous tubular and spindle cell renal cell carcinoma.

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Section: Reviewmentioning

confidence: 99%

“…Histologically, the tumor is characterized by a mixture of tubular and spindle cell components separated by variable amounts of mucinous stroma [ 12 , 7 , 8 ] (Fig. 2 ).…”

Section: Reviewmentioning

confidence: 99%

Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects

Zhao

Teng

2015

Diagn Pathol

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“…Histologically, the tumor is described by a mixture of tubular and spindle cell components, separated by variable amounts of mucinous stroma 14,16 (Figures 3 through 5). The tubules are round, ovoid, or elongated and anastomosing with a collapsed central lumen.…”

Section: Histologymentioning

confidence: 99%

“…4,7 Transitions between the elongated tubules and the spindle cells are commonly seen, and in some tumors, the spindle cell areas can be the principal component, resembling a mesenchymal neoplasm such as leiomyoma or myofibroblastoma. 16 The stroma shows extracellular mucin, which may be basophilic or occasionally eosinophilic, with a bubbly appearance. The study by Fine et al 15 in 2006 expanded the histologic spectrum of MTSCC into 2 variants: classic and mucin poor.…”

Section: Histologymentioning

confidence: 99%

Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications

Nathany

Monappa

2019

Archives of Pathology &Amp; Laboratory Medicine

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Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence of necrosis. Rare cases can show aggressive growth and distant metastasis. Mucinous tubular and spindle cell carcinoma has characteristic chromosomal abnormalities and the molecular signature remains the same, irrespective of the varied histomorphology.

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“…Hibrit onkositik/kromofob tümörler (HOKT) tanımlaması, özgün olarak böbrek onkositom ve kromofob BHK özelliklerini taşıyan tümörler için kullanılmaktadır (49). Vancouver klasifikasyonunda kromofob BHK alt grubunda değerlendirilir.…”

Section: Hibrit Onkositik/kromofob Tümörlerunclassified

Morphologic and Molecular Charecteristics of Renal Tumors

Şen¹

2015

uob

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Distal nephron neoplasms

Cited by 25 publications

References 68 publications

Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects

Mucinous tubular and spindle cell renal cell carcinoma: a review of clinicopathologic aspects

Mucinous Tubular and Spindle Cell Carcinoma: A Review of Histopathology and Clinical and Prognostic Implications

Morphologic and Molecular Charecteristics of Renal Tumors

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