Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study

Schoof, Nils; Bonin, Frederike von; König, Inke R.; Mößner, Rotraut; Krüger, Ullrich; Reich, Kristian; Berking, Carola; Volkenandt, Matthias; Ziegler, Andreas; Böckmann, Lars; Kuschal, Christiane; Thoms, Kai‐Martin; Kube, Dieter; Emmert, Steffen

doi:10.1038/gene.2009.40

Cited by 20 publications

(15 citation statements)

References 35 publications

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“…haplotype was found to be significantly associated with a reduced risk of developing melanoma (234). Also, the immune reaction against transplants appears to be influenced by polymorphisms in the promoter region of various cytokines.…”

Section: Role Of Il-10 In Immune-mediated Diseasesmentioning

confidence: 99%

“…Nevertheless, correlations between certain haplotypes of the IL-10 and IL-10R1 genes and the occurrence and/or course of various diseases were described (230)(231)(232)(233)(234)(235). In fact, in Lupus erythematosus, not only was the correlation statistically significant between the haplotype and the occurrence of disease, but also between the type of antibody and the severity of the clinical condition (230,232,236).…”

Section: Role Of Il-10 In Immune-mediated Diseasesmentioning

confidence: 99%

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Biology of interleukin-10

Sabat

Grütz

Warszawska

et al. 2010

Cytokine & Growth Factor Reviews

883

673

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Section: Role Of Il-10 In Immune-mediated Diseasesmentioning

confidence: 99%

Section: Role Of Il-10 In Immune-mediated Diseasesmentioning

confidence: 99%

Biology of interleukin-10

Sabat

Grütz

Warszawska

et al. 2010

Cytokine & Growth Factor Reviews

883

673

View full text Add to dashboard Cite

“…The polymorphisms of IL-13 (-1069CT, rs1800925; Q144R, rs20541), IL-4R (I75V, rs1805010; Q576R, rs1801275), and IL-10 (-597AC, rs1800872; -824CT, rs1800871; -1087AG, rs1800896; -3538AT, rs1800890; -6208CG, rs10494879; -6752AT, rs6676671; -7400InDel) genes were analyzed. For the analysis of the genetic variation, an Applied Biosystems ABI 7900HT instrument was used and genotyping was performed as described recently [22,25,31,32]. For quality control, 5% of the samples were genotyped in duplicate for each gene variation with an accordance of 100%.…”

Section: Dna Extraction and Genotyping Analysesmentioning

confidence: 99%

Interleukin-10 Gene Polymorphisms are Associated With Freedom From Treatment Failure for Patients With Hodgkin Lymphoma

et al. 2013

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Background. Hodgkin lymphoma (HL) is a lymphoid malignancy characterized by the production of various cytokinesImplications for Practice: Inter-individual genetic variations (polymorphisms) of host genes (patient genes) might be associated with different outcomes for cancer patients. This could be independent of the characteristics of the tumor itself. We asked if the course of Hodgkin Lymphoma patients is changed depending on the genetic background of the patient. As Hodgkin Lymphoma is characterized by an inflammatory microenvironment, we studied polymorphisms of three well-selected immune genes by molecular analysis. Our study provides evidence that a genetic variation of the IL-10 gene is associated with a worse clinical outcome in patients with HL. Although clinical practice is not changed based on these data, our study is a proof of concept and should stimulate further research in this area on a whole genome basis.

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“…Studies of promoter function continue to shed light on the role of immune-system components in health and disease (27)(28)(29)(30). To begin to explore the nature of IFN-l1 production by airway epithelial cells, we characterized the regulation of IFN-l1 transcription in a model of human airway viral infection.…”

mentioning

confidence: 99%

Regulation of IFN-λ1 Promoter Activity (IFN-λ1/IL-29) in Human Airway Epithelial Cells

Siegel¹,

Eskdale²,

Gallagher³

2011

The Journal of Immunology

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The type III (λ) IFNs (IFN-λ1, IFN-λ2, and IFN-λ3) and their receptor are the most recently discovered IFN family. They are induced by viruses and mediate antiviral activity, but type III IFNs have an important, specific functional niche at the immune/epithelial interface, as well as in the regulation of Th2 cytokines. Their expression appears diminished in bronchial epithelial cells of rhinovirus-infected asthmatic individuals. We investigated the regulation of IFN-λ1 expression in human airway epithelial cells using reporter genes analysis, chromatin immunoprecipitation, small interfering RNA knockdown, and DNase footprinting. In this article, we define the c-REL/p65 NF-κB heterodimer and IRF-1 as key transcriptional activators and ZEB1, B lymphocyte-induced maturation protein 1, and the p50 NF-κB homodimer as key repressors of the IFN-λ1 gene. We further show that ZEB1 selectively regulates type III IFNs. To our knowledge, this study presents the first characterization of any type III IFN promoter in its native context and conformation in epithelial cells and can now be applied to understanding pathogenic dysregulation of IFN-λ1 in human disease.

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Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: a case–control study

Cited by 20 publications

References 35 publications

Biology of interleukin-10

Biology of interleukin-10

Interleukin-10 Gene Polymorphisms are Associated With Freedom From Treatment Failure for Patients With Hodgkin Lymphoma

Regulation of IFN-λ1 Promoter Activity (IFN-λ1/IL-29) in Human Airway Epithelial Cells

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