Dissolving Microneedles Integrated With Liquid Crystals Facilitate Transdermal Delivery of Sinomenine Hydrochloride

A systematic review of carbohydrate-based microneedles: current status and future prospects

“… The dose and activity of the Drug was sustained after e-beam sterilization [ 70 ] HA with Nanostructured lipid carriers using Compritol, labrafil Nile red Sustained release of Nile red Effective delivery of hydrophobic component [ 118 ] HA and carboxymethyl cellulose + Amylopectin Rhodamine B Dissolves within 8 mins 10secs after application, ex-vivo in porcine skin Enhanced permeability of Drug [ 47 ] HA and carboxymethyl cellulose + Amylopectin Rhodamine B Niacinamide Approximately, 40% of dissolution of MNs seen at the end of 10 mins. Increased permeability, which can be applied for cosmetic [ 47 ] HA + 3-aminophenyl boronic acid-modified alginate Insulin Sustained release of Insulin achieved, in vivo Initiation of a maintained hypoglycemic effect in diabetic mice [ 119 ] HA cross-linked with N, N-methylene bis (acrylamide) + nanoparticles of dextran Anti-PD1 immunotherapy A synergistic effect was observed, in vivo Increased inhibition of tumor growth over the intratumoral injection [ 67 ] Sodium chondroitin sulfate + poly (vinyl pyrrolidone), lyotropic liquid crystal Sinomenine hydrochloride Sustained release of Sinomenine hydrochloride achieved to some extent, in vivo Enhanced permeability of Drug with the maintained release, which can be applied to adjuvant arthritis model rats [ 120 ] Sodium chondroitin sulfate Capsaicin Completely dissolves within 20 mins after application, in vitro Improved efficiency over a topical formulation which exhibits rapid local analgesic action [ 121 ] Sodium chondroitin sulfate Insulin fully-loaded tip and partially loaded tip with Insulin exhibit similar dissolution rate Better efficiency of the Drug, fully-loaded tip exhibit extreme effect of the Drug detected at 1.7 ± 0.2 h and 1.5 ± 0.2 h for the partially loaded tip [ 122 ] Carboxymethyl cellulose R...…”

Microneedles: materials, fabrication, and biomedical applications

“…Although some small-molecule drugs can pass through human skin, the efficiency is low. The microneedle administration can enhance the penetration efficiency of small molecule drugs (Gui et al 2017 ; Wu et al 2016 ; Cao et al 2016 ; Moreira et al 2020 ; Gao et al 2019 ; Ahmed et al 2019 ). Both the solid microneedles and the hollow microneedles have been widely studied for the administration of drugs.…”

“…8b. The specific methods are: 1) the polymer droplets were placed on an inner plate, and an outer parallel plate is not in contact with the droplets; 2) by rotating, the effect of a centrifugal force is distributed in the axial direction of a polymer droplet; 3) with the rotation, the head of the droplet rises and necks until it forms an hourglass shape in contact with the outer plate, and the droplet undergoes a centrifugal evaporation and gradually solidifies; 4) Finally, the solid fracture occurs at the narrow neck of the hourglass, which becomes a column microneedle (Yang et al 2017), as indicated in Fig. 8d.…”

“…c Fabrication of the 3D microneedle structures by drawing lithography in a glass transition . d Fabrication of the hyaluronic acid dissolving microneedles by a centrifugal lithography (CL) for (Yang et al 2017) coating processes such as changing the flow rate and applying voltage, controlled deposition of particles (100 nm to 3 μm) and fibers (400 nm to 1 μm) on MNs can be controlled directly (Haj-Ahmad et al 2015;Khan et al 2014). Angkawinitwong et al used EHDA to coat PLGA nanoparticles coated with ovalbumin on a hydrogel's MN array.…”

Transdermal Patches: State of the Art

“…13 Still, the TDDS approach appears lucrative as advantages outweigh the shortcomings as even these limitations could be overcome by using advanced approaches of transdermal delivery like prodrug approach, iontophoresis, electroporation, microneedle approach. [14][15][16][17] In 2008, Sparsha Pharma International Pvt. Ltd. became the first transdermal company in India to carry out research and development, and Manufacturing of transdermal products for global markets.…”