Dissolvable sodium alginate-based antibacterial wound dressing patches: Design, characterization, and in vitro biological studies

Feketshane, Z.; Adeyemi, S.A.; Ubanako, Philemon; Ndinteh, D. T.; Ray, Sirsendu Sekhar; Choonara, Yahya E.; Aderibigbe, B. A.

doi:10.1016/j.ijbiomac.2023.123460

Cited by 10 publications

(8 citation statements)

References 70 publications

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“…Furthermore, STAT1 regulated BST2 through the TTT CTG GGA AA sequence to promote the metastasis, invasion and proliferation capability of OSCC. STAT1 is commonly studied in the JAK signaling pathway (38,39); however, the present study demonstrated that STAT1 regulated AKT/ERK signaling by regulating BST2. To the best of our knowledge, the present study is the first to report this finding.…”

Section: Discussioncontrasting

confidence: 50%

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

Shan

Shen

Wang³

et al. 2023

Int J Oncol

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Oral squamous cell carcinoma (OSCC) is one of the main types of head and neck squamous cell carcinoma. Although progress has been made in treating OSCC, it remains a threat to human health, and novel therapeutic strategies are needed to extend the lifespan of patients with OSCC. The present study, evaluated whether bone marrow stromal antigen 2 (BST2) and STAT1 were potential therapeutic targets in OSCC. Small interfering RNA (siRNA) or overexpression plasmids were used to regulate BST2 or STAT1 expression. Western blotting and reverse transcription-quantitative PCR were performed to assess changes in the protein and mRNA expression levels of signaling pathway components. The effects of BST2 and STAT1 expression changes on the migration, invasion and proliferation of OSCC cells were assessed using the scratch test assay, Transwell assay and colony formation assay in vitro, respectively. Cell-derived xenograft models were used to evaluate the impact of BST2 and STAT1 on the occurrence and development of OSCC in vivo. Finally, it was demonstrated that BST2 expression was significantly upregulated in OSCC. Furthermore, it was demonstrated that high expression of BST2 in OSCC contributed to the metastasis, invasion and proliferation of OSCC cells. Moreover, it was demonstrated that the promoter region of BST2 was regulated by the transcription factor STAT1, and that the STAT1/BST2 axis could affect the behavior of OSCC via the AKT/ERK1/2 signaling pathway. In vivo studies also demonstrated that STAT1 downregulation inhibited OSCC growth by down-regulating BST2 expression via the AKT/ERK1/2 signaling pathway.

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Section: Discussioncontrasting

confidence: 50%

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

Shan

Shen

Wang³

et al. 2023

Int J Oncol

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“…It is difficult to make comparative studies with what is available in the scientific literature. Most published works use disk diffusion techniques [ 27 , 38 , 50 ] or MIC techniques [ 44 , 46 , 50 , 51 ]. In this case, two experiments have been performed that aim to get closer to reality by using a dressing on a wound.…”

Section: Discussionmentioning

confidence: 99%

“…These biopolymers, apart from their ability to form membranes, have antimicrobial capacity, antioxidant potential, and even possess the ability to accelerate healing [ 20 , 21 , 22 , 23 ]. The combination of both polymers has been shown to work as an effective pathway for skin regeneration [ 24 , 25 , 26 , 27 ], with the incorporation of essential oils able to increase their biological activity and therapeutic potential [ 28 , 29 , 30 , 31 , 32 ]. In previous research, the cell viability and biocompatibility of CHT/ALG + LEO membranes with HaCaT, a human epidermal keratinocyte cell line, has been demonstrated [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity Assessment of Chitosan/Alginate Lavender Essential Oil Membranes for Biomedical Applications

Cruz Sánchez,

García,

Gracia

et al. 2024

Membranes

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The demand for natural products in the treatment of dermatological pathologies has boosted the use of bioactive substances such as lavender essential oil (LEO), which stands out for its anti-inflammatory and antioxidant properties and its antimicrobial potential. Biopolymers such as chitosan (CHT) and alginate (ALG) are biodegradable and biocompatible and have proven their viability in biomedical applications such as skin regeneration. The inhibitory effect of LEO on the growth of skin-related bacterial species Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and the fungus Candida albicans was studied by incorporating 1% v/v LEO encapsulated in CHT, ALG, and CHT/ALG membranes. Despite the verification of the antimicrobial effect of all type of membranes, no synergistic effect was observed following the addition of LEO. S. aureus and P. aeruginosa showed the most growth on the different substrates and C. albicans demonstrated the highest inhibition. This is a first approach using microorganisms isolated from clinical samples or skin microbiota. Further investigation would be advisable using more clinical strains for each microorganism to validate their biomedical applicability.

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“… Dissolvable patch, based on sodium alginate and CMC, loaded with cephalexin monohydrate as an antimicrobial agent for skin and chronic wound infections. A sustained drug release is obtained for selected concentrations [ 83 ]. Chromogenic aerogel-like composite, based on CMC and PVA with an anthocyanin extract immobilized into the polymeric matrix, as a color indicator for wound pH and antimicrobial agent at the same time [ 84 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Dissolvable sodium alginate-based antibacterial wound dressing patches: Design, characterization, and in vitro biological studies

Cited by 10 publications

References 70 publications

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

Antibacterial Activity Assessment of Chitosan/Alginate Lavender Essential Oil Membranes for Biomedical Applications

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

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