Dissolvable polymer microneedles for drug delivery and diagnostics

Masood, Ali; Namjoshi, Sarika; Benson, Heather A. E.; Mohammed, Yousuf; Kumeria, Tushar

doi:10.1016/j.jconrel.2022.04.043

Cited by 57 publications

(31 citation statements)

References 248 publications

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“…A novel design of microneedles—dissolving microneedles—has been receiving substantial interest from the academic and industrial sectors ( Table 2 ). Recently, Ali and coworkers provided a comprehensive review of dissolving microneedles (especially designs and materials) for the transdermal delivery of various macromolecules [ 53 ]. These needles carry the therapeutic agents inside their polymeric matrix [ 29 ].…”

Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

“…Suitable biodegradable and water-soluble polymers for dissolving microneedles include carboxymethylcellulose [ 100 ], maltose [ 186 ], chitosan [ 60 , 187 , 188 ], polyvinyl alcohol (PVA) [ 189 ], hyaluronic acid, and polyvinylpyrrolidone. Furthermore, mild manufacturing conditions are preferable to improve the stability and protect the bioactivity of biopharmaceutical drugs [ 53 , 190 ].…”

Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

“…PLGA, chitosan, and hyaluronic acid were the most frequently used in microneedle fabrication [ 26 , 51 , 52 ]. Several research groups have recently evaluated various materials (i.e., natural, synthetic, semisynthetic polymers, and particle composites) for microneedle fabrication [ 53 , 54 , 55 ]. Microneedles made from natural materials receive substantial attention due to their excellent compatibility and minimal skin irritation [ 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

“…Researchers in academic institutions and industrial companies have developed numerous methods for microneedle fabrication on different scales. Several reviews on the fabrication techniques of microneedles can be found in the scientific literature [ 31 , 53 , 54 , 59 ]. Microneedle fabrication methods include microelectromechanical systems, micromolding technique, additive manufacturing (i.e., fused deposition modelling, stereolithography, digital light processing, photon polymerization), atomized spraying technique, X-ray technique, laser technique (i.e., laser cutting, laser ablation), droplet-born air blowing, drawing lithography, pulling pipettes, and micro-injection molding.…”

Section: Introductionmentioning

confidence: 99%

“…Microneedle-coating techniques include immersion coating, dip-coating method, layer-by-layer coating, drop-coating method, spray coating, electrohydrodynamic atomization, gas-jet drying, and piezoelectric inkjet printing. Recently, Ali et al summarized common techniques for the production of dissolving microneedles, including micromolding, drawing lithography (i.e., thermal drawing, electro-drawing, magnetorheological drawing lithography), and additive manufacturing (3D printing) [ 53 ]. Notably, 3D printing has captured great interest as a promising technique for microneedle fabrication [ 61 , 62 , 63 ].…”

Section: Introductionmentioning

confidence: 99%

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Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Nguyen

2023

Pharmaceutics

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Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due to the barrier function of the stratum corneum layer. Researchers have developed several physical enhancement techniques to expand the applications of the transdermal field; among these, microneedle technology has recently emerged as a promising platform to deliver therapeutic agents of any size into and across the skin. Typically, hydrophilic biomolecules cannot penetrate the skin by passive diffusion. Microneedle insertion disrupts skin integrity and compromises its protective function, thus creating pathways (microchannels) for enhanced permeation of macromolecules. Microneedles not only improve stability but also enhance skin delivery of various biomolecules. Academic institutions and industrial companies have invested substantial resources in the development of microneedle systems for biopharmaceutical delivery. This review article summarizes the most recent research to provide a comprehensive discussion about microneedle-mediated delivery of macromolecules, covering various topics from the introduction of the skin, transdermal delivery, microneedles, and biopharmaceuticals (current status, conventional administration, and stability issues), to different microneedle types, clinical trials, safety and acceptability of microneedles, manufacturing and regulatory issues, and the future of microneedle technology.

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Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

Section: Microneedle Types For Biopharmaceutical Deliverymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Nguyen

2023

Pharmaceutics

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Current Trends in Dissolvable Microneedles

Azeeze,

Bondalakunta,

Shukla

et al. 2024

Nanoscience and Nanotechnology for Smart Prevention, Diagnostics and Therapeutics

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Peripheral Microneedle Patch for First‐Aid Hemostasis

Lee

Park

et al. 2023

Adv Healthcare Materials

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Despite the minimized puncture sizes and high efficiency, microneedle (MN) patches have not been used to inject hemostatic drugs into bleeding wounds because they easily destroy capillaries when a tissue is pierced. In this study, a shelf-stable dissolving MN patch is developed to prevent rebleeding during an emergency treatment. A minimally and site-selectively invasive hemostatic drug delivery system is established by using a peripheral MN (p-MN) patch that does not directly intrude the wound site but enables topical drug absorption in the damaged capillaries. The invasiveness of MNs is histologically examined by using a bleeding liver of a Sprague-Dawley (SD) rat as an extreme wound model in vivo. The skin penetration force is quantified to demonstrate that the administration of the p-MN patch is milder than that of the conventional MN patch. Hemostatic performance is systematically studied by analyzing bleeding weight and time and comparing them with that of conventional hemostasis methods. The superior performance of a p-MN for the heparin-pretreated SD rat model is demonstrated by intravenous injection in vivo.

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Dissolvable polymer microneedles for drug delivery and diagnostics

Cited by 57 publications

References 248 publications

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals

Current Trends in Dissolvable Microneedles

Peripheral Microneedle Patch for First‐Aid Hemostasis

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