Dissolution thermodynamics and polymorphic transformation behaviors of glutathione

Fu, Jinqiu; Wang, Fan; Shi, Yuzhong; Wang, Chiyi; Zhao, Jingjing; Hou, Yihang; Zhuang, Wei; Ying, Hanjie; Yang, Pengpeng; Zhang, Keke

doi:10.1016/j.molliq.2023.122468

Cited by 3 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And the data of both are expressed visually in Figure S1. The solubility data of GSH in water obtained in this study were also compared with the values in reference, as shown in Table S2; the data for both are shown in Figure S2. These results demonstrated the feasibility of the method and instrument used in this study.…”

Section: Methodsmentioning

confidence: 99%

“…The melting and decomposition peaks of GSH overlapped, indicating that GSH melted and decomposed during heating; this is consistent with the literature. 15 Therefore, the melting point and enthalpy of GSH could not be determined from the TGA and DSC curves.…”

Section: Characterization Of Gshmentioning

confidence: 99%

“…Currently, the literature reports only the solubility of GSH in pure solvent water and binary solvents of water and alcoholic solvents. − This study investigates the solubility of GSH (the α form) in the binary solvents of acetone + water, 1,4-dioxane + water, acetonitrile + water, and tetrahydrofuran + water. The solubility correlation of GSH was performed using five models (modified Apelblat, CNIBS/R-K, Van’t Hoff–Jouyban–Acree, Apelblat–Jouyban–Acree, and NRTL).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measurement and Correlation of Solubility of Glutathione in Four Binary Solvents from 278.15 to 318.15 K

Jiang,

Fu,

Sun

et al. 2024

J. Chem. Eng. Data

View full text Add to dashboard Cite

The solubilities of glutathione in four binary solvent mixtures (water + acetone, water + 1,4-dioxane, water + acetonitrile, and water + tetrahydrofuran) were measured using a dynamic laser monitoring method at temperatures ranging from 278.15 to 318.15 K. The molar fraction solubility of glutathione in the binary solvent increased with increasing water content and temperature. The modified Apelblat, CNIBS/R-K, Van't Hoff−Jouyban−Acree, Apelblat−Jouyban−Acree, and NRTL were applied to calculate the solubility of glutathione in these mixtures. The relative average deviation and root-mean-square deviation indicated a good correlation between the experimental and model solubility data. In addition, the KAT-LSER model was used to evaluate the solvent effect in the solvent−solvent and solvent− solute interactions. The results showed that the nonspecific dipolarity/polarizability interactions between the solvent and the solute were the main influencing factors, followed by the hydrogen bonding interactions between the solvent and the solute.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Characterization Of Gshmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Measurement and Correlation of Solubility of Glutathione in Four Binary Solvents from 278.15 to 318.15 K

Jiang,

Fu,

Sun

et al. 2024

J. Chem. Eng. Data

View full text Add to dashboard Cite

show abstract

“…In certain conditions, polymorphic transformation could occur from the polymorph with higher Gibbs free energy to the polymorph with lower Gibbs free energy by solid−solid phase transition or solutionmediated polymorphic transformation. 13 Depending on the energy-temperature diagrams of polymorphs, the system can be classified into a monotropic polymorphism system and an enantiotropic polymorphism system, as shown in Figure 1. 14 It can be seen from Figure 1a that the Gibbs free energy of form A is lower than that of form B before melting, and there is no polymorphic transformation.…”

Section: Stabilitymentioning

confidence: 99%

“…Significantly, there is only one stable form of a given active pharmaceutical ingredient under certain circumstances, while there might be multiple unstable forms. In certain conditions, polymorphic transformation could occur from the polymorph with higher Gibbs free energy to the polymorph with lower Gibbs free energy by solid–solid phase transition or solution-mediated polymorphic transformation . Depending on the energy-temperature diagrams of polymorphs, the system can be classified into a monotropic polymorphism system and an enantiotropic polymorphism system, as shown in Figure .…”

Section: Classification and Stability Of The Polymorphsmentioning

confidence: 99%

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

Zhou,

Lv,

Liu

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

Polymorphism, which plays an important role in the pharmaceutical industry, is quite common for active pharmaceutical ingredients (API). Owing to the structural differences between polymorphs, they often possess remarkably different physical and chemical properties, thus leading to diversity in curative effects and shelf life. How to precisely control the polymorph of API has attracted the attention of researchers around the world. In this paper, the regulation methods of drug polymorphs are comprehensively reviewed, to give a better view for the future research. The traditional method, including the control of the nucleation and growth process, is systematically introduced and analyzed from the aspects of the action mechanism and their application in recent years. In addition, novel techniques, including templates, microfluidics technology, ultrasound, laser, ionic liquids, and supramolecular gels, are expounded and analyzed in detail. Considerable studies indicate that polymorph control of API is a promising research field. Finally, the existing problems are discussed and the future prospects are given.

show abstract

Insight into the dissolution behavior of valsartan (form E) in twelve pure solvents: Solubility, modelling and molecular simulation

Zhang,

Xue

et al. 2024

Journal of Molecular Liquids

View full text Add to dashboard Cite

Dissolution thermodynamics and polymorphic transformation behaviors of glutathione

Cited by 3 publications

References 50 publications

Measurement and Correlation of Solubility of Glutathione in Four Binary Solvents from 278.15 to 318.15 K

Measurement and Correlation of Solubility of Glutathione in Four Binary Solvents from 278.15 to 318.15 K

An Overview on Polymorph Preparation Methods of Active Pharmaceutical Ingredients

Insight into the dissolution behavior of valsartan (form E) in twelve pure solvents: Solubility, modelling and molecular simulation

Contact Info

Product

Resources

About