Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)-Sulfathiazole Coprecipitates

Simonelli, Anthony P.; Mehta, Surendra C.; Higuchi, William I.

doi:10.1002/jps.2600580503

Cited by 298 publications

(194 citation statements)

References 12 publications

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“…The objective of the present work is to apply the concept of a triple "C" solid dispersion system to the binary solid dispersion system of sulfathiazole and polyvinylpyrrolidone (PVP), which had been studied previously for its stability and dissolution characteristics (21,22). The term triple "C" solid dispersion system, called an internal ternary solid dispersion (ITSD) system herein, represents an innovative way to combine the advantages of both conventional solid dispersion and surface solid dispersion by utilizing the adsorptive nature of porous fine silica materials to improve the particle size and by modifying the model drug into an optimal molecular form.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Patel¹,

Dave²

2013

AAPS PharmSciTech

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Abstract. Colloidal solid dispersion is an innovative breakthrough in the pharmaceutical industry that overcomes the solubility-related issue of poorly soluble drugs by using an amorphous approach and also the stability-related issue by means of a complex formation phenomenon using different carrier materials. In the present study, a newly developed adsorption method is introduced to incorporate a high-energy sulfathiazole-polyvinylpyrrolidone (Plasdone® K-29/32) solid dispersion on porous silicon dioxide (Syloid® 244FP). Different ternary systems of sulfathiazole-Plasdone® K-29/32-Syloid® 244FP were prepared (1:1:2, 1:1:3, and 1:2:2) and categorized depending on the mechanism by which Syloid® 244FP was incorporated. Modulated differential scanning calorimetry (MDSC), X-ray diffraction, Fourier transform infrared spectroscopy, and in vitro dissolution studies were conducted to characterize the ternary systems. The X-ray diffraction and MDSC data showed a lack of crystallinity in all internal and external ternary systems, suggesting a loss of the crystallinity of sulfathiazole compared to the physical mixtures. USP apparatus II was used to measure the in vitro dissolution rate of the prepared systems at 75 rpm in different media. The dissolution rate of the optimum ratio (1:2:2) containing an internal ternary solid dispersion system was found to be three times higher than that of the external and physical systems. Thus, the porous silicon dioxide incorporated into the conventional binary solid dispersion acted as a carrier to disperse the complex and increase the dissolution rate.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Patel¹,

Dave²

2013

AAPS PharmSciTech

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“…PVP, the most commonly used surface stabilizer, was used and is an amorphous polymer that is molecular formula (C 6 H 9 NO). It has no toxicity to the human body and has very good surface film formation, so it is widely used in industries such as pharmaceuticals, dyestuffs, and adhesives [8,9]. The PVP used was the product of Aldrich, with a molecular weight of 10,000.…”

Section: Methodsmentioning

confidence: 99%

Fabrication of Nickel Nanosized Powder from LiNiO2 from Spent Lithium-Ion Battery

Shin

Lee

Wang

2018

Metals

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Abstract:In this study, a fabrication of nickel nanoparticles from LNO(LiNiO 2 ), which is a cathode active material, was synthesized by the liquid reduction process of NiSO 4 , obtained through a leaching and purification process. Hydrazine monohydrate (N 2 H 4 ·H 2 O) was used as a liquid reducing agent and it was added to NiSO 4 at a volume ratio of NiSO 4 :N 2 H 4 ·H 2 O = 10:3 and reacted for 10 min to synthesize the nickel hydrazine complex. Sodium hydroxide was added to the nickel hydrazine complex at the weight ratio of NiSO 4 :NaOH = 10:1.25-1.5 and the reduction reaction was performed at 80 • C for 15 min to synthesize nickel particles. Synthesized nickel particles were agglomerated and had a mean size of 200 nm to 300 nm. Ultrasonic dispersion, which is a physical dispersion method, was conducted. The nickel had particles of 100 nm or less when dispersed for 2 h at an ultrasonic intensity of 40 kHz. In order to prevent the agglomeration of the dispersed particles again, polyvinylpyrrolidone (PVP), an interfacial stabilizer, was added to stabilize the dispersed particles. It was confirmed that the nanoparticles were stably retained when PVP was added in an amount of 1 to 2 wt % based on the weight of the nickel. The purity of nickel recovered was found to be 99.62 wt %.

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“…The dissolution rate of APIs belonging to, the BCS II group can effectively be improved by use of salt forms with enhanced dissolution profiles (Agharkar et al, 1976), by solubilisation of drugs in co-solvents (Amin et al, 2004), by micellar solutions (Torchilin, 2007), by formation of water-soluble complexes (Casella et al, 1998), by use of lipidic systems for the delivery of lipophilic drugs (Humberstone and Charman, 1997), by increasing the specific surface area of the API according to the Noyes-Whitney equation (Kawabata et al, 2011;Whitney and Noyes, 1897) or by forming solid dispersions of amorphous APIs (Sekiguchi et al, 1964;Simonelli et al, 1969;van Drooge et al, 2006). The combinations of the last two mentioned methods can be achieved by solvent based technologies, such as spray…”

Section: Introductionmentioning

confidence: 99%

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

Sóti

Bocz

Pataki

et al. 2015

International Journal of Pharmaceutics

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Three solvent based methods: spray drying (SD), electrospinning (ES) and air-assisted electrospinning (electroblowing; EB) were used to prepare solid dispersions of itraconazole and Eudragit E. Samples with the same API/polymer ratios were prepared in order to make the three technologies comparable. The structure and morphology of solid dispersions were identified by scanning electron microscopy and solid phase analytical methods such as, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and Raman chemical mapping. Moreover, the residual organic solvents of the solid products were determined by static headspace-gas chromatography/mass spectroscopy measurements and the wettability of samples was characterized by contact angle measurement. The pharmaceutical performance of the three dispersion type, evaluated by dissolution tests, proved to be very similar. According to XRPD and DSC analyses, made after the production, all the solid dispersions were free of any API crystal clusters but about 10 wt% drug crystallinity was observed after three months of storage in the case of the SD samples in contrast to the samples produced by ES and EB in which the polymer matrix preserved the API in amorphous state.

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Dissolution Rates of High Energy Polyvinylpyrrolidone (PVP)-Sulfathiazole Coprecipitates

Cited by 298 publications

References 12 publications

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Evaluation of Colloidal Solid Dispersions: Physiochemical Considerations and In Vitro Release Profile

Fabrication of Nickel Nanosized Powder from LiNiO2 from Spent Lithium-Ion Battery

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

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