Dissolution Rates

Wurster, Dale Eric; Taylor, Palmer

doi:10.1002/jps.2600540202

Cited by 113 publications

(42 citation statements)

References 35 publications

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“…The same result was revealed when inhibition zone of 0.12% chlorhexidine solution was compared with chlorhexidine electrospun fibers at the same concentration. The Noyes-Whitney equation (23,24) defines dissolution rate (dX/dt) as follows:…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers

et al. 2014

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Abstract. Mouth-dissolving fibers with antibacterial activity for the oral cavity were prepared by an electrospinning technique. Propolis extract was used as an active ingredient and polyvinylpyrrolidone (PVP) K90 as the polymer matrix. The morphology and diameter of the fibers were characterized by scanning electron microscopy. Antibacterial activity against Streptococcus mutans and the inhibition of S. mutans adhesion on a smooth glass surface during the biofilm formation were tested. Propolis, 5% (w/ v), was combined with a PVP K90 solution, 8% (w/v), with or without Tween 80 including flavor additives and electrospun with an applied voltage of 15 kV. Uniform and smooth fibers of propolis-PVP K90 were obtained. The results showed that electrospun fibers with propolis extract can dissolve and release the propolis in water. Propolis-PVP electrospun fibers showed better antibacterial activity by reduction of bacteria adhesion on a smooth glass surface when compared to some commercial mouthwash products. These results indicated the potential of electrospun fibers to be used as mouth-dissolving fibers for effective antibacterial activity in the oral cavity.

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Section: Discussionmentioning

confidence: 99%

Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers

et al. 2014

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“…51,52 Generally, these protocols have been guided by the Noyes-Whitney equation, 53,54 which defines the dissolution rate (dX/dt) as follows:…”

Section: In Vitro Dissolution Propertiesmentioning

confidence: 99%

Solid dispersions in the form of electrospun core-sheath nanofibers

Yu¹,

Zhu²,

Branford-White³

et al. 2011

IJN

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Background:The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions. Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filamentforming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir. Results: The core-sheath nanofibers had an average diameter of 410 ± 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles. Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.

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“…16 Then, through interaction or reaction between the crystal and the adsorbed solvent molecules, the crystal molecules detach and diffuse away from the surface.…”

Section: Introductionmentioning

confidence: 99%

Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution

et al. 2017

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Effects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinyl pyrrolidone/vinyl acetate (PVP-VA), on the dissolution behaviour of the cocrystals of flufenamic acid with theophylline (FFA-TP CO) and nicotinamide (FFA-NIC CO) were investigated at multiple length scales. At the molecular level, the interactions of crystal surfaces with a polymer were analysed by observing etching pattern changes using atomic force microscopy. At the macroscopic scale, dissolution rates of particular faces of a single crystal were determined by measurement of the physical retreat velocities of the faces using optical light microscopy. In the bulk experiments, the FFA concentration in a dissolution medium in the absence or presence of a polymer was measured under both sink and non-sink conditions. It has been found that the dissolution mechanisms of FFA-TP CO are controlled by the defect sites of the crystal surface and by precipitation of the parent drug FFA as individual crystals in the bulk fluid. In contrast, the dissolution mechanisms of FFA-NIC CO are controlled by surface layer removal and by a surface precipitation mechanism, where the parent drug FFA precipitates directly onto the surface of the dissolving cocrystals. Through controlling the dissolution environment by pre-dissolving a polymer, PVP or PVP-VA, which can interact with the crystal surface to alter its dissolution properties, improved solubility and dissolution rates of FFA-TP CO and FFA-NIC CO have been demonstrated.

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Dissolution Rates

Cited by 113 publications

References 35 publications

Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers

Antibacterial Activity and Inhibition of Adherence of Streptococcus mutans by Propolis Electrospun Fibers

Solid dispersions in the form of electrospun core-sheath nanofibers

Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution

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