Dissolution Rate Studies I: Design and Evaluation of a Continuous Flow Apparatus

MRI Studies of the Hydrodynamics in a USP 4 Dissolution Testing Cell

“…A continuous flow-through apparatus was first proposed 50 years ago. 13 Since then, the USP 4 flow-through cell has gained popularity following the rising interest in process analytical technology because of its ease of automation for on-line measurements. Other benefits of the flow-through apparatus include its suitability for poorly soluble formulations and an improved ability to mimic the in vivo environment 8,14,15 in part due to the ability to switch between different biorelevant media in order to mimic pH changes along the gastrointestinal tract.…”

Membrane-Coated Tablets: A System for the Controlled Release of Drugs

“…Spray rate was 30 ml/min. Coating was continued until the weight of the coat on each tablet was 50 mg. D r u g Diffusion Studies-Potassium chloride diffusion from tablets was followed by using the modified beaker method (8,9), the ascending-column methtd (10,11), and the rotating-basket method (USP/NF). I)iffusion studies according to the beaker methtd were performed using 1000 ml of dissolution medium a t 37" and a paddle stirrer rotating a t 60 rpm.…”

Computerized Automated System for Determining Dissolution Rate Profiles for Solid Dosage Forms

“…The various procedures used for drug level measurements were reviewed (1). It is one of the few drugs for which plasma concentrations are routinely monitored, and many GLC methods (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) are suitable for the assay of steady-state levels. The dose-dependent biotransformation of phenytoin and variations in its metabolism in treated subjects require that assay methods for determining plasma concentrations of the unchanged drug and its principal metabolite, 541-hydroxyphenyl)-5-phenylhydantoin (15), suitable for single-dose pharmacokinetic studies be developed.…”