Dissolution Rate Enhancement of Dolutegravir Sodium Through Nanosuspension Technology Using 3 2 Factorial Design
Paul Bastyav Rodriques<#%##>,
Prajapati Bhupendra Gopalbhai
Abstract:Dolutegravir Sodium is a potent antiretroviral medication used in the treatment of HIV. It is BCS Class II compound and is practically insoluble at normal gastric pH range. The research aimed to discover and optimize operational and formulation factors that affect the characteristics of the drug. 3 2 factorial design was utilized for the investigation. PVP K30, Polyvinyl Alcohol, Polxammer 407, and Polxammer 188 were used in preparation of nanosupension. The formulation variables tested were the polymer concen… Show more
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