Dissolution of Zinc Oxide Nanoparticles in the Presence of Slow Acid Generators

Kürsteiner, Ronny; Ritter, Maximilian; Ding, Yong; Panzarasa, Guido

doi:10.3390/ma15031166

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…The presence of ligands such as phosphate was shown to inhibit the dissolution of nano-MnO 2 [ 45 ] and nano-CeO 2 [ 44 , 55 ]. In contrast, small organic ligands such as biologically relevant carboxylic acids (e.g., lactic, citrate, malic, succinic, acetic, glutaric, ascorbic acids) were found to enhance the release of ions from CeO 2 NPs to varying extents, at pH 4.5 [ 49 , 50 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Dissolution Behaviour of Metal-Oxide Nanomaterials in Various Biological Media

et al. 2022

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Toxicological effects of metal-oxide-engineered nanomaterials (ENMs) are closely related to their distinct physical–chemical properties, especially solubility and surface reactivity. The present study used five metal-oxide ENMs (ZnO, MnO2, CeO2, Al2O3, and Fe2O3) to investigate how various biologically relevant media influenced dissolution behaviour. In both water and cell culture medium (DMEM), the metal-oxide ENMs were more soluble than their bulk analogues, with the exception that bulk-MnO2 was slightly more soluble in water than nano-MnO2 and Fe2O3 displayed negligible solubility across all tested media (regardless of particle size). Lowering the initial concentration (10 mg/L vs. 100 mg/L) significantly increased the relative solubility (% of total concentration) of nano-ZnO and nano-MnO2 in both water and DMEM. Nano-Al2O3 and nano-CeO2 were impacted differently by the two media (significantly higher % solubility at 10 mg/L in DMEM vs. water). Further evaluation of simulated interstitial lung fluid (Gamble’s solution) and phagolysosomal simulant fluid (PSF) showed that the selection of aqueous media significantly affected agglomeration and dissolution behaviour. The solubility of all investigated ENMs was significantly higher in DMEM (pH = 7.4) compared to Gamble’s (pH 7.4), attributable to the presence of amino acids and proteins in DMEM. All ENMs showed low solubility in Gamble’s (pH = 7.4) compared with PSF (pH = 4.5), attributable to the difference in pH. These observations are relevant to nanotoxicology as increased nanomaterial solubility also affects toxicity. The results demonstrated that, for the purpose of grouping and read-across efforts, the dissolution behaviour of metal-oxide ENMs should be evaluated using aqueous media representative of the exposure pathway being considered.

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Section: Discussionmentioning

confidence: 99%

Dissolution Behaviour of Metal-Oxide Nanomaterials in Various Biological Media

et al. 2022

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“…Since then, the Tollens reaction has been used for depositing thin films and for nanoparticle synthesis, enabling a variety of applications ranging from electrical conductors to catalysis, from antimicrobial agents to plasmonics. [3][4][5][6][7] Our research concentrates on the materials science applications of clock reactions [8][9][10][11][12][13][14][15] , and during our studies we realised that the methylene glycol-sulphite (MGS) reaction, also termed "formaldehyde clock", could be suitable for the reduction of silver(I) ions to metallic silver, in close analogy with the classical Tollens reaction. The MGS reaction is a well-known pH clock featuring a sudden pH increase, from acid (𝑝𝐻 𝑖𝑛𝑖𝑡𝑖𝑎𝑙 ≈ 5.5) to alkaline (𝑝𝐻 𝑓𝑖𝑛𝑎𝑙 ≈ 11), after a highly reproducible induction time which is a function of the initial reactant concentrations.…”

mentioning

confidence: 99%

“…Our research concentrates on the materials science applications of clock reactions, 8–15 and during our studies we realised that the methylene glycol–sulphite (MGS) reaction, also termed “formaldehyde clock”, could be suitable for the reduction of silver( i ) ions to metallic silver, in close analogy with the classical Tollens reaction. The MGS reaction is a well-known pH clock featuring a sudden pH increase, from acidic (pH initial ≈ 5.5) to alkaline (pH final ≈ 11), after a highly reproducible induction time which is a function of the initial reactant concentrations.…”

mentioning

confidence: 99%