Dissolution of Theophylline from Sustained-Release Dosage Forms and Correlation with Saliva Bioavailability Parameters

Chung, Bee-Hwan; Shim, Chang‐Koo

doi:10.1002/jps.2600761006

Cited by 15 publications

(3 citation statements)

References 16 publications

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“…Furthermore, Hussein et al also reported that relative bioavailability of four sustained‐release formulation, two commercial (Theo‐Dur and Theotrin) and two experimental, were almost 100% in human 2. Also, several studies reported that the in vivo release behavior of drugs from dosage forms affected their bioavailability 20,21. Therefore, it is supposed that the difference of in vivo release behavior of TP from EC‐coated beads in the gastrointestinal tract is contributed to the discrepancy of relative bioavailability of EC‐coated beads in the three species.…”

Section: Resultsmentioning

confidence: 99%

Bioavailability and in Vivo Release Behavior of Controlled-Release Multiple-Unit Theophylline Dosage Forms in Beagle Dogs, Cynomolgus Monkeys, and Göttingen Minipigs

Ikegami

Tagawa

Ôsawa

2006

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Bioavailability and in Vivo Release Behavior of Controlled-Release Multiple-Unit Theophylline Dosage Forms in Beagle Dogs, Cynomolgus Monkeys, and Göttingen Minipigs

Ikegami

Tagawa

Ôsawa

2006

Journal of Pharmaceutical Sciences

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“…Similarly, Polli et aI. (28) have used zero-order and Day et al (29) used first-order rate constants in their correlations. In our study, each in vitro kinetic value was correlated with nine in vivo kinetic values.…”

Section: In Vitro (Basket Method)mentioning

confidence: 99%

Improving of the accuracy of in vitro-in vivo linear correlation using kinetic models for ultra sustained release theophylline tablets

Karasulu

Aktoğu²,

Karasulu

et al. 2003

European Journal of Drug Metabolism and Pharmacokinetics

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The objective of the current study was to establish and evaluate a new technique to increase the accuracy of the in vitro/in vivo linear correlation of single and multiple dose ultra-sustained release theophylline (USRT) preparation (Xantium) in hospitalized patients. In vitro dissolution data for theophylline were collected for 24 h using a USP I (basket) and USP II (paddle) methods. In vivo plasma concentration data were obtained from 8 patients after administration of either single or multiple doses of theophylline. Both in vitro and in vivo results were evaluated by zero-order, first-order, RRSBW, Hixson-Crowell, Higuchi, Hopfenberg, Langenbucher, modified Langenbucher and (Bt)a kinetic models. The individual linear correlations between each in vitro and in vivo percent results and their kinetic distributions were established and regression equations were obtained. The determination coefficient results of the linear kinetic correlations were found to be 0.994 and 0.997 for single and multiple doses by basket method and 0.992 and 0.998 for single and multiple doses by paddle method, respectively. Furthermore, the results of the linear correlations were found as 0.953 and 0.950 for single and multiple doses by basket method and 0.963 and 0.962 for single and multiple doses by paddle method respectively. Therefore, this study suggested that the accuracy of the linear correlation could be improved signilicantly by using linear kinetic correlation.

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“…Dissolution‐rate‐limited absorption (Aiache et al ., 1989; Davi et al ., 1989; Hussein & Friedman, 1990; Mojaverian et al ., 1992; Caramella et al ., 1993; Fassihi & Rislel, 1993; Harrison et al ., 1993; Humbert et al ., 1994) in particular has been emphasized in the literature and has shown high in vitro – in vivo correlation (IVIVC). Far fewer studies have emphasized permeation‐rate‐limited absorption in some cases of immediate‐release products (Strum et al ., 1978; Sylvestri & Uda, 1979; Yau & Meyer, 1981; Welling et al ., 1982; Yau & Meyer, 1983; El‐Yazigi & Sawchuk, 1985; Chung & Shim, 1987; Mayer et al ., 1992) where, as this analysis predicts, IVIVC is low. Amidon et al .…”

Section: Introductionmentioning

confidence: 99%

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

Hamamoto

Koike

Machida

2001

Vet Pharm & Therapeutics

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The effect of soybean oil refuse powder (SOR) when used as a vehicle on the absorption of oxolinic acid (OXA) powder in chicken, the dissolution profile of OXA and the correlation between in vivo and in vitro study were examined. To examine in vivo bioavailability, chickens fed or fasted were studied using a 2 x 2 crossover design. The OXA was administered OXA or OXA-SOR (1 : 9) mixture 20 mg OXA/kg. In vitro dissolution rates for OXA and OXA-SOR were measured using the paddle (PD) and the rotatory dialysis cell dissolution (PTSW) methods. Maximum plasma concentration (Cmax) and area under the curve (AUC) were significantly increased by the addition of SOR to OXA. Differences between OXA and OXA-SOR were more remarkable under fasted as compared with fed condition. In vitro dissolution rates of OXA-SOR pH 1.2, 6.5 and 7.2 as determined by the PD and the PTSW methods were increased in the presence of SOR vehicle. Differences between OXA and OXA-SOR in vitro dissolution rates were greater than in vivo bioavailability. Correlation between in vitro release (%) and in vivo absorption (%) showed good linearity (gamma=0.8805-0.9999).

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Dissolution of Theophylline from Sustained-Release Dosage Forms and Correlation with Saliva Bioavailability Parameters

Cited by 15 publications

References 16 publications

Bioavailability and in Vivo Release Behavior of Controlled-Release Multiple-Unit Theophylline Dosage Forms in Beagle Dogs, Cynomolgus Monkeys, and Göttingen Minipigs

Bioavailability and in Vivo Release Behavior of Controlled-Release Multiple-Unit Theophylline Dosage Forms in Beagle Dogs, Cynomolgus Monkeys, and Göttingen Minipigs

Improving of the accuracy of in vitro-in vivo linear correlation using kinetic models for ultra sustained release theophylline tablets

The effect of soybean oil refuse powder used as vehicle on the absorption of oxolinic acid in chickens under fasting and nonfasting conditions and the correlation with in vitro dissolution

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