Dissolution of gas bubbles moving in a liquid

Karichev, Z. R.; Muler, A. L.

doi:10.1134/s0040579506010143

Cited by 2 publications

(3 citation statements)

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“…Microelectromechanical devices utilize an oscillating microbubble to drive mixing on a chip . Medical microbubbles less than 10 μm in diameter are being developed for use as ultrasound contrast agents, − drug/gene delivery vehicles, , and oxygen carriers. , Microbubble size and lifespan are critically important for all of these applications.…”

Section: Introductionmentioning

confidence: 99%

“…Several models have been developed to predict the dissolution rate of a microbubble in a multigas medium. ,− Kabalnov et al developed a model to explain the in vivo behavior of microbubbles injected into rabbits and pigs. They adapted the EP model to consider two-gas dissolution influenced by a pressure schedule due to cardiopulmonary circulation.…”

Section: Introductionmentioning

confidence: 99%

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Microbubble Dissolution in a Multigas Environment

2010

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Microbubbles occur naturally in the oceans and are used in many industrial and biomedical applications. Here, a theoretical and experimental study was undertaken to determine the fate of a microbubble suddenly suspended in a medium with several gas species as in, for example, the injection of an ultrasound contrast agent into the bloodstream. The model expands on Epstein and Plesset's analysis to include any number of gases. An experimental system was developed which isolates the microbubble in a permeable hollow fiber submerged in a perfusion chamber, allowing rapid exchange of the external aqueous medium. Experimental verification of the model was performed with individual sulfur hexafluoride (SF(6)) microbubbles coated with the soluble surfactant, sodium dodecyl sulfate (SDS). SDS-coated microbubbles suddenly placed in an air-saturated medium initially grew with the influx of O(2) and N(2) and then dissolved under Laplace pressure. SF(6)-filled microbubbles coated with the highly insoluble lipid, dibehenoylphosphatidylcholine, were found to exhibit significantly different behavior owing to a dynamic surface tension. The initial growth phase was diminished, possibly owing to a shell "breakup" tension that exceeded the pure gas/liquid surface tension. Three dissolution regimes were observed: (1) an initial rapid dissolution to the initial diameter followed by (2) steady dissolution with monolayer collapse and finally (3) stabilization below 10 microm diameter. Results indicated that the lipid shell becomes increasingly rigid as the microbubble dissolves, which has important implications on microbubble size distribution, stability, and acoustic properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbubble Dissolution in a Multigas Environment

2010

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“…There are a number of biomedical applications that can be envisioned when this gas payload is oxygen. The systemic delivery of metabolic oxygen from purely oxygen-filled microbubbles to essential organs could significantly improve the outcome of a variety of situations in critical care. − Perfluorocarbon-based oxygen carrying MBs is already being used, − for example, to counter the resistance of hypoxic cancer tumors to radiation and chemotherapy, and purely oxygen-filled MBs (without fluorocarbons) could further improve tumor sensitization while simultaneously reducing immunogenic and renal side effects. Wound healing and organ preservation are examples of biomedical applications that would be improved by the application of a fluid containing a readily available source of oxygen.…”

Section: Introductionmentioning

confidence: 99%

Phospholipid-Stabilized Microbubble Foam for Injectable Oxygen Delivery

et al. 2010

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A detailed study is presented on the synthesis and characterization of purely oxygen-filled microbubbles (OMBs) stabilized by phospholipids. Microbubbles with a diameter of less than 10 μm were generated and concentrated to >50 vol % in saline. The lipid acyl chain length had little effect on the size distribution but profoundly affected the foam stability. For example, OMBs stabilized by dipalmitoyl phosphatidylcholine (DPPC) degraded over 3 weeks, but OMBs stabilized with distearoyl phosphatidylcholine (DSPC) retained over half of their initially encapsulated gas. Interestingly, the polydisperse size distribution remained nearly constant as the foam slowly broke down. Injection into an undersaturated solution led to the immediate release of the oxygen gas core. Injectable gas delivery by OMBs may find use in a variety of medical and industrial fields.

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Dissolution of gas bubbles moving in a liquid

Cited by 2 publications

References 0 publications

Microbubble Dissolution in a Multigas Environment

Microbubble Dissolution in a Multigas Environment

Phospholipid-Stabilized Microbubble Foam for Injectable Oxygen Delivery

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