Dissolution Method Development and Enhancement of Solubility of Clopidogrel Bisulfate

Jassim, Zainab E.; Hussein, Ahmed A.

doi:10.7897/2230-8407.08691

Cited by 7 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug release of FDT-1 and FDT-2 was similar (f 2 >50) in both media, which may be due to the similar formulation parameters in both tablets. 8,20 Confirmation of discriminating dissolution test conditions Different dissolution profiles were obtained for FDTs of varying nature ( Figures 5 and 6). In the present study dissimilarity in drug release was observed with DOM-1 compared to DOM-2 in 0.5% SLS (f 2 =26) and similarity in drug release was observed with 0.1 N HCl (f 2 =58).…”

Section: Optimization Of Dissolution Test Conditionsmentioning

confidence: 78%

Development and Validation of <i>In Vitro</i> Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug

Bhatt

Roy

Kumar

et al. 2020

tjps

View full text Add to dashboard Cite

ÖZAmaç: Hızlı dağılabilir tabletler (FDT'ler), çok hızlı dağıldıkları için in vitro etken madde salımının ayrımı ve değerlendirilmesi zordur. Bu nedenle, bu çalışmada, BCS sınıf II domperidonun FDT'leri için yeni bir in vitro ayırt edici çözünme yöntemi geliştirilmiş ve valide edilmiştir. Gereç ve Yöntemler: Domperidonun FDT'leri direkt basım yöntemi ile hazırlanmıştır. Çözünme çalışmaları sekiz istasyonlu Electrolab TDT-082 çözünme test cihazında gerçekleştirilmiştir, ultraviyole spektrofotometre ile analiz edilmiş ve taze distile su ile sodyum lauril sülfat (%0,5, % 1,0 ve %1,5), simüle bağırsak sıvısı pH 6,8 ile simüle enzimsiz mide sıvısı pH 1,2, fosfat tampon çözeltisi (pH 6,8) ve 0,1N hidroklorik asit gibi farklı çözünme ortamlarında farklı çalkalama hızlarında değerlendirilmiştir. Bulgular: Geliştirilen yöntem özgüllük, doğruluk, kesinlik, doğrusallık ve sağlamlık açısından doğrulanmıştır. Farklı ortamlar arasında, distile su ile %0,5 sodyum lauril sülfat (SLS)'nin daha yüksek ayrım gücü ile optimum olduğu bulunmuştur. Geri kazanım yüzdesi %96 ila %100,12 ve kesinlik için bağıl standart sapma değerinin (gün içi ve günler arası) %1'den az olduğu bulunmuştur. Ayrıca hazırlanan FDT'lerin %0,5 SLS içeren distile sudaki çözünme profili, salım profilinde farklılığı gösteren ve geliştirilen yöntemin ayırt edici doğasını doğrulayan benzerlik (f2) ve fark (f1) faktörü hesaplaması kullanılarak karşılaştırılmıştır. Sonuç: FDT'ler için ayırt edici çözünme yöntemi geliştirilmiş ve valide edilmiştir. Elde edilen tüm sonuçlar tatmin edici, doğru ve aralık içindedir. Mevcut yöntem, formülasyon geliştirilmesi ve FDT'lerin kalitesinin değerlendirilmesi için faydalı olabilir. Anahtar kelimeler: Validasyon, ayırt edici çözünme yöntemi, hızlı dağılabilir tabletler (FDT'ler), domperidon ABSTRACT Objectives: Fast dispersible tablets (FDTs) get dispersed very fast due to which the discrimination of in vitro drug release and their evaluation is difficult. Hence in the present study a new in vitro discriminatory dissolution method was developed and validated for FDTs of domperidone of BCS class II. Materials and Methods: FDTs of domperidone were prepared by direct compression method. The dissolution studies were performed in an eightstation Electrolab TDT-082 dissolution testing apparatus, analyzed by ultraviolet spectrophotometer and evaluated in different dissolution mediums i.e. sodium lauryl sulphate (0.5%, 1.0% and 1.5%) with fresh distilled water, simulated intestinal fluid pH 6.8, simulated gastric fluid pH 1.2 without enzymes, phosphate buffer solution (pH 6.8) and 0.1 N hydrochloric acid at different agitation speeds. Results: The developed method was validated in terms of specificity, accuracy, precision, linearity and robustness. Amongst the different mediums, 0.5% sodium lauryl sulfate (SLS) with distilled water was found to be optimum with higher rate of discriminatory power. The percentage recovery was found to be 96 to 100.12 % and the % relative standard deviation value for precision (intraday and interday) was foun...

show abstract

Section: Optimization Of Dissolution Test Conditionsmentioning

confidence: 78%

Development and Validation of <i>In Vitro</i> Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug

Bhatt

Roy

Kumar

et al. 2020

tjps

View full text Add to dashboard Cite

show abstract

“…Then a calibration curve was plotted concentration in μg/ml on X-axis and absorbance on Y-axis. 9 Fourier Transport Infrared Spectroscopy:…”

Section: Methodsmentioning

confidence: 99%

Design and Evaluation of Sustained Release Matrix Tablets of Antihyperlipidemic Drug

Chaudhari¹,

Vyawahare²,

Phad³

2018

AJPTR

View full text Add to dashboard Cite

The aim of present work was to design and evaluate sustained release matrix tablets of antihyperlipidemic drug. In the present investigation, polymers used in different combinations such as Eudragit RL100 and HPMC E5 in the ratio of 1:1, 1:2, 1:3 and vice versa with PVP K25 using direct compression technique were prepared. The tablets were evaluated for physical parameters like thickness, hardness, friability, weight variation, and in vitro release studies. The FTIR study indicated that the drug is stable in formulation. The maximum drug release was found to be 94.41% over a period for 12 hours for F4 batch, thus concluded that as the concentration of Eudragit RL100 is increased the drug release decreased. The drug release mechanism followed non-fickian transport from both polymer matrices. All the formulations were stored at 25 0 C/60% RH and 45 0 C/75% RH for 3 months. It showed that all the formulations were physically and chemically stable.

show abstract

“…Differential scanning calorimetry and XRD demonstrate that lyophilized clopidogrel powder and tablet are amorphous. [75] Zhao et al precipitated genipin of mean PS of 1.8l μm with entire chemical structure and reduced crystallinity were reported as observed by scanning electron microscope (SEM) and thermogravimetric analysis, which resulted in a faster dissolution and better bioavailability than crystals. The dissolution rate and solubility were 2.08 and 1.64 times that of raw crystal, respectively.…”

Section: Antisolvent Precipitation Of Apismentioning

confidence: 99%

“…Differential scanning calorimetry and XRD demonstrate that lyophilized clopidogrel powder and tablet are amorphous. [ 75 ]…”

Section: Application Of Mixing For the Precipitation Of Apismentioning

confidence: 99%

Hydrodynamics and Transport Mechanism of Microfluidic Mixing in Precipitation of Nanodrugs: A Review

Behera

Patel

Parikh

2023

Cryst. Res. Technol.

View full text Add to dashboard Cite

Poor aqueous solubility drugs are a concern of pharmaceutical industries due to low dissolution rates and low bioavailability. Various approaches and techniques address these issues by customizing drug micro–nanonization, as investigated by many researchers. Establishing a compelling synthesis of tailored nanoparticles with highly variable qualities intended for therapeutic applications needs the flexibility to vary particle size, content, crystallinity, and shape. Such an approach necessitates getting to the desired yield and developing a synthetic process that is durable, reproducible, and scalable. However, precipitation techniques to produce nanoparticles are more convenient than other approaches. Liquid antisolvent precipitation is one of the robust crystal manipulation approaches extensively used for producing nanoparticles, where mixing sets the basis to create supersaturation followed by corresponding quality precipitation. Various process intensification equipments are in use for adequate mixing‐based precipitation. Nowadays, microfluidic precipitation system is gaining interest in the production of nanodrugs. Further, the use of ultrasound in a microfluidic system improves the mixing quality by cavitation phenomena. This review focuses on the transport phenomena and hydrodynamics involved in mixing to enhance the mass transfer during antisolvent precipitation of synthesized nanodrugs in the microfluidic system.

show abstract

Dissolution Method Development and Enhancement of Solubility of Clopidogrel Bisulfate

Cited by 7 publications

References 9 publications

Development and Validation of <i>In Vitro</i> Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug

Development and Validation of <i>In Vitro</i> Discriminatory Dissolution Testing Method for Fast Dispersible Tablets of BCS Class II Drug

Design and Evaluation of Sustained Release Matrix Tablets of Antihyperlipidemic Drug

Hydrodynamics and Transport Mechanism of Microfluidic Mixing in Precipitation of Nanodrugs: A Review

Contact Info

Product

Resources

About