Dissolution mechanism of ibuprofen-casein compacts

Optimization of desolvation process for fabrication of lactoferrin nanoparticles using quality by design approach

“…Milk proteins are natural vehicles for therapeutic molecules. Milk protein such as casein and whey proteins have been reported previously, as carrier for drug delivery in form of micelles, NPs, beads, composites , hydrogels, microparticles, and microspheres (Bulgarelli et al 1999, Chen et al 1987, Gubbins et al 2003, Gunasekaran et al 2007, Knepp et al 1993, Millar and Corrigan 1993, Song et al 2009, Zimet et al 2013. Use of milk as drug delivery vehicle has been recently reported by researchers (Kytariolos et al 2013).…”

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

“…The improvement in dissolution was related to the complexation with casein and processing of the drug [ 494 ]. Millar et al further characterized the dissolution rate of the compacts over a range of compositions and found that the dissolution rate of acidic casein was half that of sodium caseinate [ 495 ]. Using ibuprofen as the model drug, they showed that acidic casein compacts significantly slowed drug dissolution compared to sodium caseinate compacts.…”

“…They attributed the difference to the changing form of casein that took place due to microenvironmental pH differences in the boundary layer. Acidic casein was also more viscous and rigid than sodium caseinate, which decreased its solubility and reduced drug diffusivity [ 495 ]. A subsequent research group demonstrated that acidic casein and sodium caseinate could be mixed with other materials, such as hydroxypropylmethocellulose matrices, to slow drug dissolution [ 496 ].…”

Digestibility and structural parameters of spray-dried casein clusters under simulated gastric conditions

“…Numerous studies have reported that caseins and their products could be used as natural vehicles for drugs, such as ibuprofen, theophylline, phenytoin, and flutamide (Elzoghby, Helmy, Samy, & Elgindy, 2013;Latha, Rathinam, Mohanan, & Jayakrishnan, 1995;Millar & Corrigan, 1993;Watanabe, Hanawa, Sugihara, & Yamamoto, 1994). Moreover, they were suggested to improve the solubility and bioavailability of hydrophobic bioactives, such as curcumin and vitamin D 2 , as well as used to protect probiotic bacteria against gastric digestion (Heidebach, Forst, & Kulozik, 2009;Menéndez-Aguirre et al, 2011;Nag, Han, & Singh, 2011;Pan, Zhong, & Baek, 2013).…”