Dissolution enhancement of drugs. part i: technologies and effect of carriers

Abstract

and full-text of published articles. The journal is devoted to the promotion of health sciences and related disciplines (including medicine, pharmacy, nursing, biotechnology, cell and molecular biology, and related engineering fields). It seeks particularly (but not exclusively) to encourage multidisciplinary research and collaboration among scientists, the industry and the healthcare professionals. It will also provide an international forum for the communication and evaluation of data, methods and findings in health sciences and related disciplines. The journal welcomes original research papers, reviews and case reports on current topics of special interest and relevance. All manuscripts will be subject to rapid peer review. Those of high quality (not previously published and not under consideration for publication) will be published without delay. The maximum length of manuscripts should normally be 10,000 words (20 single-spaced typewritten pages) for review, 6,000 words for research articles, 3,000 for technical notes, case reports, commentaries and short communications.

Investigation of Cyclodextrin Inclusion Compounds Using FT-IR, SEM and X-Ray Diffraction

“…After the completion of reaction, the precipitate so obtained (β-CD:Tram MO) is separated using Whatman filter paper, and dried in vaccum oven. Microwave irradiation method is a novel method for industrial scale preparation due to its major advantage of shorter reaction time and higher yield of the product [7].…”

Applicability of sucrose laurate as surfactant in solid dispersions prepared by melt technology

“…Solid dispersions of hydrophobic drugs in water-soluble carriers have attracted considerable interest as a means of improving dissolution behaviour, and hence enhancing bioavailability. Water-soluble carriers such as high-molecularweight polyethylene glycols (PEGs) and polyvinylpyrrolidones (PVPs) have been most commonly used for solid dispersions (Bikiaris et al, 2005;Craig and Newton, 1991;Leuner and Dressman, 2000;Saharan et al, 2009;Serajuddin, 1999). The use of surfactants with solubilizing properties, such as polysorbates, poloxamers, Gelucires (polyethylene glycol glycerides), sodium lauryl sulfate or vitamin E TPGS have also attracted considerable interest recently (Dehghan and Jafar, 2006;Jagdale et al, 2010;Liu and Wang, 2007;Mura et al, 1999;Okonogi and Puttipipatkhachorn, 2006;Owusu-Ababio et al, 1998;Sethia and Squillante, 2002;Vasconcelos et al, 2007).…”

Orodispersible Liquisolid Compacts: A Novel Approach to Enhance Solubility and Bioavailability

“…Several mechanisms of enhanced drug release have been postulated for liquisolid systems (Saharan, 2009). The three main proposed mechanisms include increased surface area of drug available for release, increased aqueous solubility of the drug due to presence of non-volatile vehicle and improved wettability of the drug particles due to co solvent effect of the vehicle used.…”