Dissolution characteristics of cylindrical particles and tablets

Oxidation of magnesium sulfite is important for recycle of byproduct in the magnesium desulfurization. The oxidation rate of magnesium sulfite, prepared by vacuum evaporation method, was investigated in a bubbling tank in presence of transition metal catalysts, which shows cobalt is the most effective. The general reaction orders with respect to cobalt, magnesium sulfite, and oxygen are 0.44, 0, and 0.46, respectively, and the apparent activity energy is 17.43 KJ·mol. The catalytic performance of cobalt compared with other metals was also analyzed employing the ion potential theory. Integrated with the three-phase reaction model, we inferred that the general oxidation rate of magnesium sulfite is controlled by mass transfer of oxygen. Further, the intrinsic kinetics was predicted, indicating that the reaction orders with respect to cobalt and oxygen are 1.0 and 0, respectively. The results are helpful for the recycle of magnesium sulfite in magnesia desulfurization.

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“…Furthermore, the dissolution rate of magnesium sulfite can be expressed by Noyes−Whitney equation 30 as follows:…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, the dissolution rate of magnesium sulfite can be expressed by Noyes–Whitney equation as follows: R normalB = ∂ c ∂ t = k normalp S normaln ( c Sat − c S false( IV false) ) …”

Section: Discussionmentioning

confidence: 99%

Oxidation Rate of Magnesium Sulfite Catalyzed by Cobalt Ions

Wang

Zhao

et al. 2014

Environ. Sci. Technol.

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“…Numerous articles have been published on traditional process variables that affect the dissolution performance of immediate and sustainedrelease dosage forms [1][2][3][4][5][6][7][8][9][10][11][12]. The aim of this work was to determine if a deeper understanding of dissolution might be possible by analyzing all available raw material properties, process parameters and external environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Capitalizing on Aggregate Data for Gaining Process Understanding––Effect of Raw Material, Environmental and Process Conditions on the Dissolution Rate of a Sustained Release Product

Stryczek

Horáček²,

Kléma

et al. 2007

J Pharm Innov

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Continuous improvement of pharmaceutical manufacturing operations has not evolved at the same rate as it has in other industries. Although time-series data are routinely collected as part of equipment control systems, the data are usually not thoroughly evaluated. This article investigates batch data, in-process and release laboratory test data and time-series data from granulation, fluid-bed drying and coating operations in an effort to determine which parameters are most critical to the dissolution of a matrixrelease, solid oral dosage form of a poorly soluble drug.

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Selectivity of transition metal catalysts in promoting the oxidation of solid sulfites in flue gas desulfurization

Wang

Pan

et al. 2015

Applied Catalysis A: General

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Dissolution characteristics of cylindrical particles and tablets

Cited by 13 publications

References 15 publications

Oxidation Rate of Magnesium Sulfite Catalyzed by Cobalt Ions

Oxidation Rate of Magnesium Sulfite Catalyzed by Cobalt Ions

Capitalizing on Aggregate Data for Gaining Process Understanding––Effect of Raw Material, Environmental and Process Conditions on the Dissolution Rate of a Sustained Release Product

Selectivity of transition metal catalysts in promoting the oxidation of solid sulfites in flue gas desulfurization

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