Dissociative symptoms as measured by the Cambridge Depersonalization Scale in patients with a bipolar disorder

Tuineag, Maria; Therman, Sebastian; Lindgren, Maija; Rouanet, Manon; Nahon, Sara; Bertrand, Lia; Saury, Sybille; Renaud, Suzane; Beaulieu, Serge; Linnaranta, Outi

doi:10.1016/j.jad.2019.11.137

Cited by 11 publications

(12 citation statements)

References 48 publications

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“…The High depersonalization class was characterized by a higher rate of comorbid bipolar disorder. This is in line with research indicating a high prevalence of comorbid depression in DDD patients (Baker et al, 2003;Michal et al, 2016), the presence of lifetime dissociative symptoms in individuals with bipolar disorder (Mula et al, 2009) and an association between the severity of dissociation and self-reported trauma history in both patients with bipolar disorder (Tuineag et al, 2020) and borderline personality disorder (Sar et al, 2017).…”

Section: Discussionsupporting

confidence: 91%

Symptom variability in depersonalization–derealization disorder: A latent profile analysis

et al. 2021

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Objective Depersonalization–derealization disorder (DDD) is characterized by diverse symptomatology overlapping with anxiety and dissociative disorders, but the sources of this variability are poorly understood. This study aims to determine whether symptom heterogeneity is attributable to the presence of latent subgroups. Method We applied latent profile analysis to psychometric measures of anxiety, depersonalization–derealization, and dissociation in 303 DDD patients. Results The analysis yielded evidence for five discrete subgroups: three of varying severity levels and two moderate‐to‐severe classes characterized by differential dissociative symptoms. The five classes reliably differed on several nondissociative symptoms, comorbidities, and factors precipitating their diagnosis but did not significantly differ in other symptoms including anxiety. Conclusion These results suggest the presence of three distinct DDD subtypes in the upper severity range that are distinguished by differential expression of detachment and compartmentalization symptoms. Further elucidation of these subtypes has potential implications for the etiology, mechanisms, and treatment of DDD.

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Section: Discussionsupporting

confidence: 91%

Symptom variability in depersonalization–derealization disorder: A latent profile analysis

et al. 2021

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“…Though some researchers have reported no difference in DS severity scores between BD-I and BD-II ( 23 , 24 ), there is some evidence that DS and particularly depersonalization symptoms may be more severe in BD-I ( 30 , 42 ). Only one study assessed DS in patients with other BD subtypes (BD-III and BD not otherwise specified) along with BD-I and BD-II, but the small number of cases in this subgroup precluded a meaningful comparison ( 41 ).…”

Section: Resultsmentioning

confidence: 99%

Dissociative Symptoms and Disorders in Patients With Bipolar Disorders: A Scoping Review

Rajkumar

2022

Front. Psychiatry

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Dissociative disorders are an important group of trauma-related disorders associated with significant disability. The co-occurrence of dissociative disorders (DD) and symptoms (DS) in bipolar disorder has been relatively understudied, but there is some evidence that this comorbidity may have significant mechanistic and clinical implications. This paper presents the results of a scoping review of the frequency and correlates of DS and DD in bipolar disorder. Based on the available evidence, DS/DD are more common in bipolar disorder than in healthy controls or in unipolar depression, are related to childhood trauma, and are associated with psychotic symptoms, suicide attempts, and a poorer response to treatment in patients with bipolar disorder. The implications of these findings, and possible mechanistic pathways underlying them, are discussed based on the current literature. Clinicians should be aware of the frequent occurrence of significant DS or DD when treating patients with bipolar disorder. A tentative future research agenda for this field, based on clinical, risk factor-related and neurobiological considerations, is outlined.

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“…A recent meta-analysis found that dissociative experiences are most prevalent in dissociative disorders (DID, dissociative amnesia, depersonalization/derealization disorder, dissociative fugue, and dissociative disorder not otherwise specified), followed by PTSD, BPD, and conversion disorder [2••]. Dissociation can also occur as a symptom of schizophrenia [27], major depressive disorder [28], bipolar disorder [29], and obsessive-compulsive disorder [30]. The differentiation between psychotic and dissociative symptoms can be challenging [31,32].…”

Section: Clinical Presentationsmentioning

confidence: 99%

Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment

Krause-Utz

Frost

Chatzaki

et al. 2021

Curr Psychiatry Rep

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Purpose of Review The aim of this review article is to give an overview over recent experimental neurobiological research on dissociation in borderline personality disorder (BPD), in order to inform clinicians and to stimulate further research. First, we introduce basic definitions and models that conceptualize dissociation from a transdiagnostic perspective. Then, we discuss recent findings in BPD. Recent Findings Stress-related dissociation is a key symptom of BPD, closely linked to other core domains of the disorder (emotion dysregulation, identity disturbances, and interpersonal disturbances). The understanding of neurobiological correlates of dissociation across different psychiatric disorders (e.g., dissociative disorders, post-traumatic stress disorder) is steadily increasing. At the same time, studies explicitly focusing on dissociation in BPD are still scarce. Summary There is evidence for adverse effects of dissociation on affective-cognitive functioning (e.g., interference inhibition), body perception, and psychotherapeutic treatment response in BPD. On the neural level, increased activity in frontal regions (e.g., inferior frontal gyrus) and temporal areas (e.g., inferior and superior temporal gyrus) during symptom provocation tasks and during resting state was observed, although findings are still diverse and need to be replicated. Conceptual differences and methodological differences in study designs and sample characteristics (e.g., comorbidities, trauma history) hinder a straightforward interpretation and comparison of studies. Given the potentially detrimental impact of dissociation in BPD, more research on the topic is strongly needed to deepen the understanding of this complex clinical condition.

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Dissociative symptoms as measured by the Cambridge Depersonalization Scale in patients with a bipolar disorder

Cited by 11 publications

References 48 publications

Symptom variability in depersonalization–derealization disorder: A latent profile analysis

Symptom variability in depersonalization–derealization disorder: A latent profile analysis

Dissociative Symptoms and Disorders in Patients With Bipolar Disorders: A Scoping Review

Dissociation in Borderline Personality Disorder: Recent Experimental, Neurobiological Studies, and Implications for Future Research and Treatment

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