Dissociative Electron Attachment to Biomolecules

Bald, Ilko; Čurík, Roman; Kopyra, Janina; Tarana, Michal

doi:10.1007/978-3-319-43030-0_5

Cited by 10 publications

(5 citation statements)

References 172 publications

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“…The assignment of DEA resonances in dry DNA films to the individual DNA components , and the theoretical rationale for DNA damage by DEA , have triggered intense investigations of DEA to biomolecules. An overview can be found in recent reviews. − …”

Section: Introductionmentioning

confidence: 99%

Electron Attachment to Microhydrated Deoxycytidine Monophosphate

et al. 2018

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DNA constituents are effectively decomposed via dissociative electron attachment (DEA). However, the DEA contribution to radiation damage in living tissues is a subject of ongoing discussion. We address an essential question, how aqueous environment influences the DEA to DNA. In particular, we report experimental fragmentation patterns for DEA to microhydrated 2-deoxycytidine 5-monophosphate (dCMP). Isolated dCMP was previously set as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond. We show that hydrated molecules decompose via dissociation of the C-N glycosidic bond followed by dissociation of the P-O bond. This significant change of the proposed mechanism can be interpreted by a reactive role of water in the postattachment dynamics. Comparison of the fragmentation with previous macroscopic irradiation studies suggests that the actual contribution of DEA to DNA radiation damage in living tissue is rather small.

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Section: Introductionmentioning

confidence: 99%

Electron Attachment to Microhydrated Deoxycytidine Monophosphate

et al. 2018

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“…The very wide * s resonance involved in this DEA process is extremely difficult to detect in ab initio calculations where it is normally hidden by the dipole and polarisation enhanced non-resonant contribution to the scattering. (We refer the reader to Bald et al (2017) for a more detailed discussion of the process and the work done to investigate it. )…”

Section: Dea and Resonance Parametersmentioning

confidence: 99%

“…A prior review (Baccarelli et al 2011) described the work performed up to 2011, particularly on resonance formation and DEA. We also refer the reader to two recent reviews of DEA (Fabrikant et al 2017) and DEA to biomolecules (Bald et al 2017) for more details regarding this process. In this Topical Review, we will concentrate on work carried out after 2011 and include all electron-induced processes as well as a wider the range of targets including aggregates.…”

Section: Introductionmentioning

confidence: 99%

Electron scattering from molecules and molecular aggregates of biological relevance

Gorfinkiel

Ptasińska

2017

J. Phys. B: At. Mol. Opt. Phys.

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In this Topical Review we survey the current state of the art in the study of low energy electron collisions with biologically relevant molecules and molecular clusters. We briefly describe the methods and techniques used in the investigation of these processes and summarise the results obtained so far for DNA constituents and their model compounds, amino acids, peptide and other biomolecules. The applications of the data obtained is briefly described as well as future required developments.

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“…Examples are halogen-, thio-, azido-or cyano-substituted DNA bases [2][3][4][5], bromopyruvic acid [6], nitroimidazoles [7][8][9] or halogenated nucleosides [10,11]. This fact, together with well known action of secondary low-energy electrons during the radiation interaction with living matter [12][13][14], induced significant efforts to explore the role of secondary electrons in the radiosensitization (see, e.g., recent reviews [15][16][17][18]). Several mechanisms have been proposed, which may be important and may be even used to rationally design new radiosensitizers and chemo-radiotherapy drugs.…”

Section: Introductionmentioning

confidence: 99%