Dissociation of uterine eosinophilia and water imbibition from other estrogen-induced responses by nafoxidine pretreatment

Galand, Paul; Tchernitchin, N. N.; Tchernitchin, Andrei N.

doi:10.1016/0303-7207(85)90053-x

Cited by 18 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histochemical studies showed that the uterine cervix is also a region with a pronounced stromal density of peroxidase-containing cells. In adult animals, estrogen treatment results in uterine eosinophilia [8,9]; and most, if not all, of the induced peroxidase activity was ascribed to this eosinophilia which has been associated with nongenomic (edema, vascular permeability, histamine release) response to estrogen [8,9,35,36]. The results in this study from experiments involving enzyme inhibitors indicate that the cervical stromal cells contain at least two types of peroxidases which has also been demonstrated for uterine eosinophils in adult rats [37].…”

Section: -mentioning

confidence: 61%

Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol

Andersson¹,

Forsberg²

1988

Teratog Carcinog Mutagen

View full text Add to dashboard Cite

Neonatal female NMRI mice were treated with daily doses of 10(-2) or 5 micrograms diethylstilbestrol (DES) on one or more of days 1-5 after birth. Using immunohistochemical techniques and a monoclonal antibody to the estrogen receptor, we demonstrated an estrogen-induced precocious appearance of receptor protein in the nuclei of the uterovaginal epithelium. High levels of peroxidase activity and a pronounced stromal infiltration with peroxidase positive cells occurred in the uterine cervix and upper vagina after estrogen treatment. This regional restriction in peroxidase activity was similar to the regional restriction for estrogen-induced epithelial abnormalities (heterotopic columnar epithelium, adenosis). A combined treatment with DES and corticosterone depressed peroxidase activity but not to the control level. The distribution of abnormal epithelium was similar in DES- and DES-corticosterone-treated females. The conclusion is that neonatal estrogen treatment induces an epithelial receptor for estrogen and a high level of cervical peroxidase activity, but the relationship between these parameters and the appearance of abnormal cervicovaginal epithelial changes could not be settled in the present study.

show abstract

Section: -mentioning

confidence: 61%

Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol

Andersson¹,

Forsberg²

1988

Teratog Carcinog Mutagen

View full text Add to dashboard Cite

show abstract

“…1981 have been proposed as well. The existence of multiple and independent mechanisms of estrogen action for the different responses to hormone stimulation results in a dissociation of these responses under a Ž number of conditions Tchernitchin et al, 1975Tchernitchin et al, , 1985bGaland, 1982, 1983;Galand et al, . 1985 .…”

Section: Introductionmentioning

confidence: 96%

Antiestrogenic activity of lead

Tchernitchin

Villagra

Tchernitchin

1998

Environ. Toxicol. Water Qual.

View full text Add to dashboard Cite

“…Results from this laboratory suggest that histamine is involved in the early (3 h) response to oestradiol but that it does not appear to play a major role in the uterine response to tamoxifen (Marshall & Senior, 1986). Tamoxifen may be more dependent on, for example, the eosinophil-mediated mechanism proposed by the Tchernitchin group (Galand et al, 1985;Tchernitchin, 1979;Tchernitchin, 1983) as they have shown that nafoxidine, also a triphenylethylene derivative, can induce eosinophil migration (Galand et al, 1984). The reversal of the combined blood flow response at 27 h and 72 h may also indicate a different mediatory system.…”

Section: Discussionmentioning

confidence: 94%

The effect of a single dose of oestradiol on tamoxifen‐induced uterine hyperaemia and growth in the rat

Marshall

Senior

1989

British J Pharmacology

View full text Add to dashboard Cite

1 The effect of oestradiol on tamoxifen -(single doses of each agent) induced responses in the uterus of the mature ovariectomized rat was investigated. The parameters examined were uterine blood flow (measured by the microsphere technique), weight and oestrogen receptor concentrations. 2 Initially the addition of oestradiol to the tamoxifen regimen produced a reduction in uterine blood flow and dry weight which was reflected by a reduction in nuclear oestrogen receptor. However, as the tamoxifen response became more established from 48 h onwards the addition of oestradiol produced an additive effect. These changes were not mirrored by increases in nuclear oestrogen receptor.3 The results suggest that tamoxifen and oestradiol may, in part, act via different mechanisms; the role of possible mediatory systems such as histamine release and eosinophil migration is discussed. Heterogeneous control systems may also be involved in the early and late uterine response.

show abstract

Dissociation of uterine eosinophilia and water imbibition from other estrogen-induced responses by nafoxidine pretreatment

Cited by 18 publications

References 15 publications

Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol

Induction of estrogen receptor, peroxidase activity, and epithelial abnormalities in the mouse uterovaginal epithelium after neonatal treatment with diethylstilbestrol

Antiestrogenic activity of lead

The effect of a single dose of oestradiol on tamoxifen‐induced uterine hyperaemia and growth in the rat

Contact Info

Product

Resources

About